The Effect of Intravenous Paracetamol on Postoperative Pain after Lumbar Discectomy

Shimia, Mohammad; Parish, Masoud; Abedini, Naghi

doi:10.4184/asj.2014.8.4.400

Cited by 24 publications

(32 citation statements)

References 20 publications

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“…The 2 RCTs that tested tramadol found that it did not reduce pain scores but it was more effective than placebo and less effective than fentanyl in reducing opioid consumption . The 2 RCTs that tested paracetamol found that it was more effective than placebo and less effective than dexketoprofen in reducing pain scores . The RCTs that tested systemic lidocaine, ketorolac, and NSAIDs (tenoxicam) led to controversial results .…”

Section: Resultsmentioning

confidence: 99%

Prevention and Treatment of Postoperative Pain after Lumbar Spine Procedures: A Systematic Review

et al. 2018

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Clinical evidence on perioperative pain management in patients undergoing spine procedures have significantly evolved after the review published in 2012. The aim of this systematic review was to report the latest evidence published. These include the preoperative use of dexamethasone, which was shown to be able to reduce pain at mobilization but not to reduce pain at rest or total morphine consumption; the use of gabapentinoids as part of a multimodal analgesic approach; and the safety and effectiveness of the intraoperative use of ketamine, dexketoprofen, and tramadol. Finally, electrical nerve stimulation is gaining interest and is potentially suitable for clinical needs.

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Section: Resultsmentioning

confidence: 99%

Prevention and Treatment of Postoperative Pain after Lumbar Spine Procedures: A Systematic Review

et al. 2018

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“…In patients undergoing lumbar discectomy post-operative pain was adequately controlled by starting intravenous acetaminophen 20 minutes before start of surgery. 4 In patients undergoing total abdominal hysterectomy it was concluded that a pre-emptive intravenous dose of 1 gm provides good quality of postoperative analgesia and results in a decreased consumption of morphine. 5 In This study also we found that intravenous formulation was better overall in post-operative pain scores.…”

Section: Discussionmentioning

confidence: 99%

“…Here in this study we wish to compare the efficacy in between the two in controlling post-operative pain after general anaesthesia for short duration surgeries. [1][2][3][4][5] Study aimed to compare the efficacy of 1 gram acetaminophen oral dose with 1 gram acetaminophen intravenous dose, to estimate whether oral route acetaminophen is effective in controlling post operative pain and to compare the pain scores for oral and intravenous acetaminophen at each time intervals.…”

Section: Introductionmentioning

confidence: 99%

A Pre Induction Administration of One Gram Oral or Intravenous Acetaminophen in Control of Post-Operative Pain: A Comparative Study

Sahoo¹

2019

IJCMR

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Introduction: Post operative pain after surgery is a cause of significant morbidity and patient dissatisfaction. In this study we try to compare efficacy between 1 gram acetaminophen oral dose with 1 gram acetaminophen intravenous dose in controlling post operative pain. Material and methods: This study is a prospective, randomized and comparative study conducted at NRI institute of medical sciences, Visakhapatnam between Oct 2016 to October 2017. 90 patients belonging to ASA status I and II of both genders, age group-18 to 60 years and undergoing surgeries under general anaesthesia lasting less than 2 hours were enrolled for the study. 2 groups out of which Group A received 1gm oral paracetamol and Group B received 1gm intravenous paracetamol. The grous were compared post operatively for pain scores at 30, 60, 90, 120, 150 minute after surgery using visual analogua scale(VAS) results: The mean VAS scores were 2.78, 4.07, 5.81, 6.36, 6.5 for Group A and 2.18, 3.5, 4.76, 6.04, 6.43 for Group B. Thus pain scores were consistently lesser in Group B than Group A. Pain scores were significantly lower in Group B during the time period 30 mins and 90 mins (p values 0.039 and 0.002 respectively). The time of first rescue analgesia (i.e, Fentanyl) was compared in both the groups. Mean for time of demand for analgesia was 88.67 mins and 102 mins in Group A and Group B respectively. P value was 0.05 thus a significantly earlier requirement of rescue analgesia in Group A. Conclusion: The rescue analgesic requirement was significantly lesser in intravenous acetaminophen group. Hence 1gm intravenous paracetamol is superior to oral formulation in controlling post operative pain.

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“…5,6 Acetaminophen (Paracetamol) has been successfully used for management of postoperative pain in different types of operations. 7,8 Studies conducted in the past to assess the efficacy of acetaminophen in attenuating the DOI: 10.29309/TPMJ/2020.27. 2.3921 hemodynamic presser response 9,10 found it to be efficacious.…”

Section: Introductionmentioning

confidence: 99%

“…Acetaminophen, a non-opioid analgesic, does not cause adverse effects associated with opioids such as respiratory depression, nausea and vomiting. 7,8 Also, it has few contraindications and no significant drug interactions. 12 Keeping in view a better profile of acetaminophen in regard to adverse effects, contraindications, and interactions with other drugs, we wanted to find out if it could be used instead of nalbuphine in attenuating the presser response during orotracheal intubation while administering general anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

Comparison of acetaminophen and nalbuphine in attenuating hemodynamic response to tracheal intubation.

Faridi¹,

Nasir²,

Haider³

et al. 2020

TPMJ

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Laryngoscopy and tracheal intubation causes sympathetic over activity in the form of increased heart rate and blood pressure, which may lead to deleterious effects. Opioid drugs like fentanyl and nalbuphine are routinely used to attenuate this response during intubation. A few studies have claimed that acetaminophen is efficacious for this purpose too. Various studies have explored its role in blunting of pressor response but none have compared it with nalbuphine. We compared these drugs with the purpose, if both drugs are equally effective; acetaminophen would be a better alternative to nalbuphine without adverse effects of an opioid. Objectives: The objective of this study was to compare the efficacy of acetaminophen and nalbuphine in attenuating hemodynamic response during tracheal intubation. Study Design: Randomized, double-blind clinical trial. Setting: Main operation theatre complex of Fauji Foundation Hospital Rawalpindi. Period: From August to December 2018. Material & Methods: After obtaining permission from institutional ethical review committee of Fauji Foundation Hospital Rawalpindi. 60 Patients of ASA physical status I and II, aged 30 to 55 years, undergoing abdominal surgical procedure of 1 to 3 hour duration were randomly divided into two groups. Patients in group N received nalbuphine hydrochloride 0.15 mg/kg body weight intravenously, 30 minutes before induction. Patients in group P received acetaminophen infusion (paracetamol) 15mg/kg body weight intravenously, 30 minutes before induction. Systolic and diastolic blood pressures were measured manually and heart rate by pulse oximeter. Observations were made before giving analgesics, during induction, 1 minute after intubation, then at every 1- minute intervals till first 5 minutes, and thereafter at 10 minutes and at 15 minutes after intubation. The descriptive statistics of data were expressed as mean and standard deviation. Independent samples t-test was used for comparison of mean values of the variables in both groups. The value of p< 0.05 was considered as statistically significant. Results: There was a significant rise in heart rate and blood pressure after laryngoscopy and endotracheal intubation with acetaminophen (P group) as compared to the N group in which nalbuphine effectively reduced the tachycardia and hypertension. Conclusion: Acetaminophen has no significant effect on the prevention of hemodynamic changes due to intubation. Nalbuphine effectively reduces tachycardia and hypertension associated with laryngoscopy and endotracheal intubation.

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The Effect of Intravenous Paracetamol on Postoperative Pain after Lumbar Discectomy

Cited by 24 publications

References 20 publications

Prevention and Treatment of Postoperative Pain after Lumbar Spine Procedures: A Systematic Review

Prevention and Treatment of Postoperative Pain after Lumbar Spine Procedures: A Systematic Review

A Pre Induction Administration of One Gram Oral or Intravenous Acetaminophen in Control of Post-Operative Pain: A Comparative Study

Comparison of acetaminophen and nalbuphine in attenuating hemodynamic response to tracheal intubation.

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