The effect of iodide iontophoresis on the antioxidative capacity of the tear fluid

Rieger, G.; Klieber, M; Schimetta, Wolfgang; Pölz, Werner; Griebenow, S.; Winkler, Rudolf; Horwath‐Winter, Jutta; Schmut, O.; Spitzer-Sonnleitner, Birgit

doi:10.1007/s00417-010-1416-8

Cited by 11 publications

(4 citation statements)

References 48 publications

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“…Iontophoresis is a process by which ions or charged molecules in solution are applied to body surfaces and introduced into cells and tissues with the use of electric current. Iodide iontophoresis increases the water-soluble antioxidative capacity of tear fluid mitigating the effects of ROS, which may alleviate the symptoms of dry eyes (Rieger et al 2010). In a non-randomized interventional clinical trial, the effectiveness of iodide iontophoresis and iodide application without current in moderate-to-severe dry eye patients was compared; 16 patients were treated with iodide iontophoresis and 12 patients with iodide application without current for 10 days.…”

Section: Intervention Studies In Humansmentioning

confidence: 99%

Dry eye disease and oxidative stress

Seen

Tong

2017

Acta Ophthalmologica

231

162

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Dry eye, an age-related condition, is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability. Environmental factors are also often implicated in dry eye including exposure to pollutants, ultraviolet (UV) radiation and ozone as well as the chronic use of preserved eyedrops such as in the treatment of glaucoma. These factors increase oxidative stress and ocular surface inflammation. Here, we reviewed the cellular, animal and clinical studies that point to the role of oxidative stress in dry eye disease. The biomarkers used to indicate oxidative damage in ocular surface tissues include 8-hydroxy-2 deoxyguanosine (8-OHdG), 4-hydroxynonenal (HNE) and malondialdehyde (MDD). Antioxidative defences in the ocular surface occur in the form of tear proteins such as lactoferrin and S100A proteins, and enzymes such as superoxide dismutase (SOD), peroxidase, catalase and mitochondrial oxidative enzymes. An imbalance between the level of reactive oxygen species (ROS) and the action of protective enzymes will lead to oxidative damage, and possibly inflammation. A small number of interventional studies suggest that oxidative stress may be directly targeted in topical therapy of dry eye treatment. For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may be helpful. Examples of treatments used in clinical trials include vitamin B12 eyedrops and iodide iontophoresis. With recent emphasis on ageing medicine and preventive holistic health, as well as the role of environmental science, research on oxidative stress in the ocular surface is likely to have increasing impact in the coming years.

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Section: Intervention Studies In Humansmentioning

confidence: 99%

Dry eye disease and oxidative stress

Seen

Tong

2017

Acta Ophthalmologica

231

162

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“…Clinical trials have verified that an electric current with the density of 20 mA/cm 2 for 5 min would be harmless to the corneal tissue (Voigt, Kralinger, et al., 2002 ; Hao et al., 2009 ; Patane et al., 2011 ). Previous study also shows that an electric current with the density of 5.0 mA/cm 2 for 10 min would not cause any intraocular complications in transscleral iontophoresis (Rieger et al., 2010 ; Jung et al., 2018 ). However, the higher electric current (with the densities of 100–Y0 mA/cm 2 ) would cause retina and choroid burns, hemorrhagic necrosis, edema and infiltrations in the subjects (Yoshizumi et al., 1995 ; Eljarrat-Binstock et al., 2010 ; Rahić et al., 2020 ).…”

Section: Factors Affecting Iontophoresismentioning

confidence: 83%

Application of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye

Dong

et al. 2023

Drug Delivery

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Delivery of drugs to special locations of ocular lesions, while minimizing systemic and local toxic effects, is recognized as a critical challenge in the ophthalmic practice. The special anatomy and physiology barriers within the eyeball entail effective drug delivery systems. Emerging attempts in drug delivery has led to developments in ocular iontophoresis, which acts as a noninvasive technology to enhance drug penetration using a small electric current. This technique offers greater flexibility to deliver desired drug dose in a controlled and tolerable manner. In previous studies, this technique has been testified to deliver antibiotics, corticoid, proteins and other gene drugs into the eye with the potency of treating or alleviating diverse ophthalmological diseases including uveitis, cataract, retinoblastoma, herpes simplex and cytomegalovirus retinitis (CMVR), etc. In this review, we will introduce the recent developments in iontophoresis device. We also summarize the latest progress in coulomb controlled iontophoresis (CCI), hydrogel ionic circuit (HIC) and EyeGate II delivery system (EGDS), as well as overview the potential toxicity of iontophoresis. We will discuss these factors that affect the efficacy of iontophoresis experiments, and focus on the latest progress in its clinical application in the treatment of eye diseases.

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“…However, its use is limited by the potential cytotoxic effects of iodide on corneal epithelial and endothelial cells. [23][24][25]…”

Section: Dry Eye Diseasesmentioning

confidence: 99%

Oxidative stress and antioxidants in ocular disorders

Maurya,

Tiwari

2024

IJOOO

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The effect of iodide iontophoresis on the antioxidative capacity of the tear fluid

Abstract: The increase of ACW in tear fluid after iodide iontophoresis can support the defense mechanism of the eye against oxidative influence effects, which may alleviate the symptoms of keratoconjunctivitis sicca.

Cited by 11 publications

References 48 publications

Dry eye disease and oxidative stress

Dry eye disease and oxidative stress

Application of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye

Oxidative stress and antioxidants in ocular disorders

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