The effect of iodine deficiency and propylthiouracil on the hypothalamo–pituitary–thyroid axis in the neonatal rat

Dussault, J H; Walker, P. Roy

doi:10.1139/y78-151

Cited by 28 publications

(12 citation statements)

References 4 publications

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“…together with a serum TSH level <5 pU/ ml, although still detectable. Persistently elevated TSH levels in spite of normal T4 and T3, especially if accompa nied by retardation in bone maturation, should be consid ered to indicate insufficient dosage or insufficient com pliance with therapy [2,69,70] rather than impairment of feedback control and reduced pituitary sensitivity to T4 resulting from hypothyroidism during fetal life [71], Follow-up of CH infants and children is routine. Clini cal examination, evaluation of growth including bone maturation [72], determination of scrum total and free T4 and T3 and TSH [73], as well as an evaluation of the psy chomotor and intellectual development will be performed at regular intervals.…”

Section: Treatment and Prognosis O F Permanent Sporadic Chmentioning

confidence: 99%

Neonatal Screening for Congenital Hypothyroidism Results and Perspectives

Delange¹

1997

Horm Res

201

110

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Systematic screening for congenital hypothyroidism in the neonate constitutes a major progress in the prevention of mental retardation, as the condition occurs in 1/4,000 newborns and necessarily results in brain damage if not properly detected and treated during the first days of life. Screening and diagnostic and therapeutic procedures are discussed, as well as outcome and prognosis of the affected infants. Primary thyroid-stimulating hormone screening is almost universally recommended. Early therapy (within 14 days) with appropriate doses of thyroxine (about 10 µg/kg/day) will prevent any brain damage even in case of evidence of fetal hypothyroidism, as thyroxine of maternal origin will reach the fetus and largely protect him. Neonatal thyroid screening is also a particularly sensitive monitoring tool in the evaluation of the effects and of the correction of iodine deficiency at the population level.

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Section: Treatment and Prognosis O F Permanent Sporadic Chmentioning

confidence: 99%

Neonatal Screening for Congenital Hypothyroidism Results and Perspectives

Delange¹

1997

Horm Res

201

110

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“…The ovine species was not chosen for these studies since term AF rT3 concentrations are low in the sheep (8). Previously published rat (9)(10)(11)(12)(13)(14)(15)(16)(17) and primate (18,19) models of fetal hypothyroidism were not used since hypothyroidism had been induced at birth rather than in the fetus or combined maternal-fetal hypothyroidism resulted from the treatment regimen. When an effort was made to prepare isolated fetal hypothyroidism, pharmacologic doses of T4 were administered to dams receiving antithyroid drugs and/or a low-iodine diet (LID) (20).…”

Section: Introductionmentioning

confidence: 99%

Maternal Thyroid Function is the Major Determinant of Amniotic Fluid 3,3′,5′-Triiodothyronine in the Rat

El-Zaheri¹,

Vagenakis²,

Hinerfeld³

et al. 1981

J. Clin. Invest.

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“…Neonatal hypothyroidism, induced by iodine deficiency or administration of propylthiouracil (PTU), results in marked modifications in the ontogenetic pattern of the hypothalamic-pituitary-thyroid axis (3)(4)(5).…”

mentioning

confidence: 99%

“…Both Bakke et al (6,7) and Azizi et at. (8) have shown that rats rendered hyperthyroid during the neonatal period have significantly reduced serum T 4 and TSH concentrations as adults. Little is known, however, of the mechanism^) by which these modifications occur.…”

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confidence: 99%

Effects of Neonatal Hyperthyroidism on the Development of the Hypothalamic-Pituitary-Thyroid Axis in the Rat*

1982

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The acute and latent effects of neonatal hyperthyroidism (NH) on the hypothalamic-pituitary-thyroid axis were studied in the rat after treatment of newborn animals with L-T4 (0.4 microgram/g BW, daily) for a period of 12 days. NH was associated with a permanent reduction in body weight in both male and female rats, in addition to a delay in the attainment of peak concentrations of hypothalamic TRH and pituitary and serum TSH. Serum TSH, T4, and T3 concentrations also were significantly and permanently reduced in NH animals (P less than 0.01) after cessation of L-T4 treatment. The serum TSH secretory response to 1 microgram synthetic TRH also was evaluated in 120-day-old control and NH rats, before and after the administration of L-T4 (0.6 microgram/100 g BW for 7 days) or propylthiouracil (0.05% in the drinking water for 14 days). In the baseline state, adult NH rats had a net secretory response similar to that of controls (189.0 +/- 31.3 vs. 227.0 +/- 29.3 microgram/ml . min). Administration of T4 significantly decreased while propylthiouracil treatment significantly increased the net TSH secretory response of NH rats compared to similarly treated control rats. These data are compatible with the hypothesis that NH leads to a permanent resetting of the regulatory set-point for pituitary TSH secretion and to increased sensitivity to the feedback inhibitory effects of thyroid hormones.

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The effect of iodine deficiency and propylthiouracil on the hypothalamo–pituitary–thyroid axis in the neonatal rat

Cited by 28 publications

References 4 publications

Neonatal Screening for Congenital Hypothyroidism Results and Perspectives

Neonatal Screening for Congenital Hypothyroidism Results and Perspectives

Maternal Thyroid Function is the Major Determinant of Amniotic Fluid 3,3′,5′-Triiodothyronine in the Rat

Effects of Neonatal Hyperthyroidism on the Development of the Hypothalamic-Pituitary-Thyroid Axis in the Rat*

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