The effect of ionizing radiation on metoprolol

Ogrodowczyk, Magdalena; Marciniec, B; Czwajda, Aleksandra

doi:10.3109/03639045.2012.692379

Cited by 6 publications

(8 citation statements)

References 16 publications

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“…It is known that the presence of impurities including decomposition products and also radiodegradation products, causes a decrease in the melting point of a given drug. The melting point of non-irradiated nadolol sample was in the range 129.5-135.9°C (Table 1) which is in agreement with literature values 124-136°C (Moffat et al 2011).…”

Section: Resultssupporting

confidence: 80%

Radiodegradation of nadolol in the solid state and identification of its radiolysis products by UHPLC–MS method

et al. 2017

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Nadolol ((2R*,3S*)-5-{[(2R*)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4 tetrahydronaphthalene-2,3-diol) in substantia was exposed to ionizing radiation generated by a beam of high-energy electrons in an accelerator, in the standard sterilisation dose of 25 kGy and in higher doses of 50 -400 kGy. The irradiated and non-irradiated (control) samples were analysed by the infrared spectrophotometry, electron paramagnetic resonance, differential scanning calorimetry (DSC) and ultrahigh performance liquid chromatography coupled with mass spectrometry (UHPLC-MS). The irradiated samples were found to contain free radicals in concentrations much higher than that observed for the other irradiated b-blockers. On the basis of UHPLC-MS results, it was possible to establish structures of 11 compounds of the impurities and/ or products of nadolol decomposition. The main product of radiodegradation was concluded to be formed as a result of abstraction of the hydroxyl group and aromatization of the tetrahydronaphthalene ring. The results of DSC measurements confirmed the presence of radiolysis products in the irradiated samples of nadolol. A shift of the endothermic peak corresponding to melting towards lower temperatures (by 4.4°C at the dose of 400 kGy) was directly proportional to the doses of radiation used, which permits concluding that this method is sensitive and suitable for evaluation of radiodegradation of nadolol in solid phase.

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Section: Resultssupporting

confidence: 80%

Radiodegradation of nadolol in the solid state and identification of its radiolysis products by UHPLC–MS method

et al. 2017

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“…However, inspecting the decrease of melting point (T f ) of the metoprolol tartrate with the absorbed doses D (Fig. 13) it was observed similar behaviour with the decrease of pH of metoprolol tartrate solution used in the previous work 3 . We conclude that there is probably a causal correlation revealed by Fig.…”

Section: Effect Of Absorbed Doses On Ph and Melting Point Of Metoprolsupporting

confidence: 69%

“…For the experimental conditions used in the previous work 3 , we found numerically the following expression:…”

Section: Effect Of Absorbed Doses On Ph and Melting Point Of Metoprolmentioning

confidence: 93%

“…Experimental. Experimental details are presented in the previous work 3 where metoprolol tartrate in solid phase was irradiated by high-energy electrons beam using an accelerator at doses varying from 0 to 400 kGy, while the obtained experimental pH-values were measured in aqueous solutions formed by 0.1500 g of metoprolol tartrate, irradiation at different doses (D) and then dissolved in 3 mL of distilled water 3 . More details are given in previous work 3 .…”

Section: Effect Of the Electron-radiation On Metoprolol Tartratementioning

confidence: 99%

“…f With a correlation coefficient equivalent to R = 0.99505. Note we have used as a melting point T f (D), approximately the center of each interval given in the previous study 3 .…”

Section: Effect Of Absorbed Doses On Ph and Melting Point Of Metoprolmentioning

confidence: 99%

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Modeling of the irradiation effect on some physicochemical properties of metoprolol tartrate for safe medical uses

Ouerfelli

Vrînceanu

Mliki

et al. 2020

Sci Rep

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The effect of gamma-irradiation and ionizing radiation (high-energy electrons beam) on the physicochemical properties of metoprolol tartrate at the solid phase and aqueous solution, has been investigated in the present study to model some properties affected by absorbed doses and to reveal some interesting mutual causal correlation. The proposed some interesting models can be adapted to other experimental conditions, and the newly obtained values of the adjustable parameters could be an excellent criterion of the state quality of the metoprolol tartrate or for other additional interpretations. The peculiar behaviour of variation of physicochemical properties against dose leads us to confirm the suggested optimized doses mentioned in previous work, for sterilization and safe medical uses. As a synthetic β-1 adrenoceptor-blocking agent, the metoprolol tartrate (Fig. 1) is an antihypertensive drug and also used to treat different conditions such as high blood pressure, heart failure, and angina (chest pain) 1-3. Moreover, the metoprolol tartrate is used in industrial sterilization by ionizing radiation (β and γ rays or by high-energy electrons beans) 1,2,4-6. It was noticed that ionizing radiation works by energy transfer through the adsorption of this energy by the target materials 4-11. Generally, the ionization of materials occurs at room temperature and the treatment depth varies with the nature and dose of radiation. Our works suggest that an excessive radiation dose can cause breaks in the chromosomal DNA of some microorganisms at the biological cellular-level, which can lead to their damage or death. In previous work, γ-irradiation (0-50 kGy) on metoprolol tartrate 1 for which; thermal analysis (such as Thermogravimetric analysis (TGA) and Differential thermal analysis (DTA)), X-ray analysis, UV-analysis, IR spectra, and high-pressure liquid chromatography show good analysis. As, the metoprolol tartrate has high resistance to γ-adsorbed doses (20 to 40) kGy and that's why it conserves approximately its crystallinity. Moreover, this behaviour is also observed in the case of a high-energy electron beam irradiation 3. It was concluded that this interval of doses can be utilized safely for metoprolol tartrate sterilization (ISO 11137) for special pharmaceutical and medical applications. In this work, we will try to give an optimal dose value between 20 and 40 kGy of γ-irradiation. Similarly in previous work we have used high-energy electron beam irradiation (from 0 to 400 kGy) on metoprolol tartrate at solid phase 3. The effect of irradiation dose has been inspected and tested by some analytical methods such as chromatography, UV and IR spectrophotometry and electron magnetic resonance (EPR). We

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Physicochemical Stability of Space Medicines

Mehta

Bhayani

2022

Handbook of Space Pharmaceuticals

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The effect of ionizing radiation on metoprolol

Cited by 6 publications

References 16 publications

Radiodegradation of nadolol in the solid state and identification of its radiolysis products by UHPLC–MS method

Radiodegradation of nadolol in the solid state and identification of its radiolysis products by UHPLC–MS method

Modeling of the irradiation effect on some physicochemical properties of metoprolol tartrate for safe medical uses

Physicochemical Stability of Space Medicines

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