The effect of ionotropic gelation residence time on alginate cross-linking and properties

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

“…The plateau phase is instead due to the gastro-resistant potential of calcium alginate, which can strongly limit the drug release at low pH values (González-Rodríguez et al, 2002). This effect has been explained considering that the carboxylate groups of the polymer are protonated in SGF, forming unionized alginic acid, insoluble in water, whose lack of charges gives rise to a decreased repulsion between the polymeric chains, and, consequently, to a decrease of water uptake and swelling rate, leading to a marked reduction of drug release (Patel, 2017).…”

“…Calcium alginate is a polyanionic polymer widely investigated for its potential to control drug delivery in the intestinal tract, due to its ability to shrink at acidic pH and swell at neutral or basic pH, joined to excellent mucoadhesion properties, biodegradability, biocompatibility and absence of toxicity (González-Rodríguez et al, 2002;George and Abraham, 2006;Patel et al, 2008Patel et al, , 2017Agarwal et al, 2015). Alginate beads have been successfully used as a vehicle for liposomes (Xing et al, 2003;Bansal et al, 2016) to protect the entrapped hydrophilic drugs and release them to the lower bowel, after specific local biodegradation of the polymer.…”

Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium

“…The ionic gelation method are widely used due the high stability of synthesized particles, use of water‐based solutions, mild reaction condition without organic solvent and simple cost‐effective process . This technique has been adopted for natural carbohydrate polymers to produce biocompatible and biodegradable products . Many researches in ionic gelation are targeted at developing new drug delivery systems …”

Structure and dynamics of hagfish mucin in different saline environments

“…17 Ionotropic gelation, also called polyelectrolyte complexation is based on the ability of polyelectrolyte molecules to form hydrogels in the presence of counterions even below the entanglement concentration. [22][23][24][25] Although previous works studied hagfish mucin vesicles and hagfish mucin in stabilization solutions and different saline environments, still little is known about the fundamental interactions of hagfish mucin with salts and especially calcium ions. In this work we investigated the structure and dynamics of hagfish mucin over broad length and time domains and focused especially on the effect of different salt environments.…”