The effect of iproniazid and tranylcypromine studied with a dark-avoidance conditioned schedule

Bucci, L; Bovet, D

doi:10.1007/bf00429584

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Morrison and Stephenson (13) reported that rats avoided the brightly-illuminated arm of Y-maze when the other arms were dark. Bucci and Bovet (14) discussed that light was evidently perceived by rats as an adverse stimulus which hindered them from moving toward the light. The pre sent data showed that mice also stayed in the darkened compartment unless an electric shock forced them to leave there.…”

Section: Resultsmentioning

confidence: 99%

A Simple Avoidance Procedure for Testing Psychotropic Drugs in Mice

Oka

Shimizu

1975

Japanese Journal of Pharmacology

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Abstract-A simple avoidance procedure in mice was investigated for the purpose of testing psychotropic drugs. A box with two compartments, darkened and lightened, was used. Mice were put into the darkened compartment where they would be punished unless they moved into the lightened compartment within 5 sec. Most of mice quickly acquired an active avoidance in this apparatus with training less than 50 successive trials. Major tranquilizers such as chlorpromazine, haloperidol, clozapine and oxypertine depressed the avoidance response at doses lower than those at which the escape re sponse was impaired. Diazepam and doxepin had depressant effects at doses which impaired the escape response. Imipramine and nortriptyline did not affect the avoid ance response at the doses tested. It is concluded that mice quickly acquire an active avoidance under the present procedure and that this conditioned behavior is selec tively depressed by major tranquilizers.Conditioned avoidance techniques such as shuttle box procedure (1, 2), unsignaled Sid man avoidance procedure (3, 4) and operant signaled avoidance procedure (5), have been widely used in studies of psychotropic drugs. These techniques have the merit that the "normal" behavior of animals is stable and reproducible . Most of the methods, however, are inconvenient for studies using a large number of animals as they are time-consuming and require a large amount of equipment utilization to produce stable response rates. Many investigators used rats for such behavioral research and these animals are more expensive than mice.

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Section: Resultsmentioning

confidence: 99%