The effect of iron deficiency anemia on the function of the immune system

Ekiz, Ceyda; Ağaoğlu, Leyla; Karakaş, Zeynep; Gürel, Nuray; Yalçın, Işık

doi:10.1038/sj.thj.6200574

Cited by 236 publications

(185 citation statements)

References 27 publications

Supporting

Mentioning

156

Contrasting

Unclassified

Order By: Relevance

“…In contrast with our fi ndings, Ekiz et al [5] reported that there was no change in the T-lymphocyte numbers and distribution of subgroups in cases with IDA. The reported T-cell dysfunction may be the result of functional defects of T-cells rather than quantitative defects.…”

Section: Discussioncontrasting

confidence: 99%

“…While the prevalance of iron defi ciency varies across the world, It is well known that children and women in the reproductive age group are especially vulnerable to iron defi ciency [1]. Both experimental and some clinical studies have emphasized the importance of iron in the integrity of the immune system especially in the innate immunity and the cellular component system of active immunity [5].…”

Section: Discussionmentioning

confidence: 99%

“…Its defi ciency affects the capacity to have an adequate immune response as it is necessary for immune cell proliferation and the generation of specifi c response to infection [4]. Despite proven reversible functional immunological defects, a clinically important relationship between states of iron defi ciency and susceptibility to infections remain controversial [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of iron deficiency anemia and its treatment on cell mediated immunity

Attia¹,

Essa²,

Nosair³

et al. 2009

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

Iron defi ciency anemia (IDA) is one of the most prevalent micronutrient defi ciencies particularly in the developing countries. While there is evidence of an altered immune profi le in iron defi ciency, the exact immunoregulatory role of iron is not known. Knowledge particularly in children, who are vulnerable to iron defi ciency and infection, is lacking. We aimed to study the effects of IDA and its treatment with oral iron supplementation on cell-mediated immunity. The levels of T-lymphocytes, their CD4 + , CD8 + and CD1a + subsets, transferrin receptor (CD71) and serum ferritin were evaluated in 40 iron-defi cient and 40 healthy children. The impact of oral iron supplementation for three months on the same parameters was also noted in children with IDA. The level of mature T-lymphocytes (CD4 + and CD8 + ) was signifi cantly lower (P<0.001) while that of the immature T-cells (CD1a + ) was signifi cantly higher (p<0.001) in IDA children compared to the control. The mature T-cell count was signifi cantly improved after iron therapy. In spite of signifi cant reduction in the immature T-cells (CD1a+) level after iron supplementation, it was signifi cantly higher than the control. The present study demonstrated that T-lymphocytes maturation was defective in IDA and improved partially after 3 months of iron supplementation. Therefore, longer time of iron therapy may be required to induce complete maturation of T-lymphocytes.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of iron deficiency anemia and its treatment on cell mediated immunity

Attia¹,

Essa²,

Nosair³

et al. 2009

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

show abstract

“…Selenium supplementation prevents cell damage and plays an important role in the development, fertility, and immune functions of humans and other vertebrates, including fish (Hoffmann and Berry, 2008;Schrauzer and Surai, 2009). However, its deficiency causes many metabolic disorders and diseases such as calf pneumonia, white muscle disease in calves and beef cows, exudative diathesis, and infertility in fish and other vertebrates; thus, a lack of selenium exerts a negative influence on the immune function (Muller et al, 2002;Ekiz et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary selenium nanoparticles on physiological andbiochemical aspects of juvenile Tor putitora

Khan¹,

Zuberi²,

Nazir³

et al. 2016

Turk J Zool

102

View full text Add to dashboard Cite

A 70-day feeding trial was conducted to evaluate the effects of dietary supplementation of selenium nanoparticles (Se-NPs) on physiological and biochemical aspects of juvenile mahseer (Tor putitora) fish. Maintaining a 40% protein level, 2 different experimental diets supplemented with 0% Se-NPs and 0.68 Se-NPs mg kg -1 were fed to triplicate groups of fish. The experiment was conducted in a semistatic condition consisting of 6 fiber tanks. The fish were first acclimatized, and then 30 fish per tank were randomly put into each fiber tank. At the end of the feeding trial, samples were collected from the fish and analyzed. Results obtained showed that the diet supplemented with Se-NPs significantly increased (P < 0.05) physiological aspects like red blood cell count, hemoglobin level, hematocrit values, and lysozyme activity as compared to the basal diet. Similarly, biochemical parameters including serum growth hormone levels, tissue total protein content, and glutathione peroxidase activity in liver and muscle tissues of T. putitora also significantly (P < 0.05) increased. Thus, dietary Se-NP supplementation at the rate of 0.68 mg kg -1 diet has very beneficial effects on the physiobiochemical health aspects of juvenile T. putitora.

show abstract

“…Iron deficiency has been associated with defects in both adaptive and innate immunity (Cunningham-Rundles et al 2005). Furthermore, iron deficiency anaemia in children is associated with reductions in both phagocytic activity and immunoglobulin levels (Ekiz et al 2005).…”

mentioning

confidence: 99%