The Effect of Irreversible Electroporation on Blood Vessels, Bile Ducts, Urinary Tract, Intestines, and Nerves

Vogel, Jantien A.; Vroomen, Laurien G. P. H.; Srimathveeravalli, Govindarajan

doi:10.1007/978-3-319-55113-5_5

Cited by 7 publications

(4 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, IRE preserves the extracellular matrix of vasculatures and shows better safety profiles in the vicinity of vital structures such as blood vessels, bile ducts, and the urinary tract. [ 30 ] However, the cytotoxicity of IRE depends on the strength of electric pulses, which decreases as the distance between the tumor cells and electrodes increases. The intratumoral heterogeneity may also form regions of low pulse strength where tumor cells can survive.…”

Section: Discussionmentioning

confidence: 99%

Local Release of TGF‐β Inhibitor Modulates Tumor‐Associated Neutrophils and Enhances Pancreatic Cancer Response to Combined Irreversible Electroporation and Immunotherapy

et al. 2022

View full text Add to dashboard Cite

Pancreatic cancer is a deadly disease with little response to standard therapies. Irreversible electroporation (IRE) has emerged as a novel ablative technique for the clinical treatment of pancreatic cancer. Combinations of IRE and immunotherapies, including anti-programmed death 1 (𝜶PD1) immune checkpoint blockade, have shown promising efficacy in both preclinical and clinical studies. However, tumor recurrence remains an obstacle that needs to be overcome. It herein is shown that IRE induces a substantial infiltration of neutrophils into pancreatic tumors. These neutrophils are then polarized into a protumor phenotype by immunosuppressive cues, in particular transforming growth factor 𝜷 (TGF-𝜷). Using glutathione-responsive degradable mesoporous silica nanoparticles loaded with SB525334, an inhibitor of TGF-𝜷1 receptor, it is demonstrated that local inhibition of TGF-𝜷 within the tumor microenvironment promotes neutrophil polarization into an antitumor phenotype, enhances pancreatic cancer response to combined IRE and 𝜶PD1 therapy, and induces long-term antitumor memory. The therapeutic efficacy is also attributed to tumor infiltration by CD8 + cytotoxic T cells, depletion of regulatory T cells, and maturation of antigen-presenting dendritic cells. Thus, modulating neutrophil polarization with nanomedicine is a promising strategy for treating pancreatic cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Local Release of TGF‐β Inhibitor Modulates Tumor‐Associated Neutrophils and Enhances Pancreatic Cancer Response to Combined Irreversible Electroporation and Immunotherapy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Compared to thermal ablative methods, IRE offers several advantages, especially for pancreatic tumors. The HVEPs preserve the collagen framework of adjacent delicate structures, allowing for cellular regeneration [ 73 ]. In addition, the efficacy of the HVEPs is not hindered by the heat-sink effect.…”

Section: Locoregional Ablation Brachytherapy Chemotherapy and Immunotherapymentioning

confidence: 99%

Locally Advanced Pancreatic Cancer: Percutaneous Management Using Ablation, Brachytherapy, Intra-arterial Chemotherapy, and Intra-tumoral Immunotherapy

et al. 2021

View full text Add to dashboard Cite

Purpose of Review Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasms, bearing a terrible prognosis. Stage III tumors, also known as locally advanced pancreatic cancer (LAPC), are unresectable, and current palliative chemotherapy regimens have only modestly improved survival in these patients. At this stage of disease, interventional techniques may be of value and further prolong life. The aim of this review was to explore current literature on locoregional percutaneous management for LAPC. Recent Findings Locoregional percutaneous interventional techniques such as ablation, brachytherapy, and intra-arterial chemotherapy possess cytoreductive abilities and have the potential to increase survival. In addition, recent research demonstrates the immunomodulatory capacities of these treatments. This immune response may be leveraged by combining the interventional techniques with intra-tumoral immunotherapy, possibly creating a durable anti-tumor effect. This multimodality treatment approach is currently being examined in several ongoing clinical trials. Summary The use of certain interventional techniques appears to improve survival in LAPC patients and may work synergistically when combined with immunotherapy. However, definitive conclusions can only be made when large prospective (randomized controlled) trials confirm these results.

show abstract

“…Contraindications include cardiac arrhythmias and pacemaker-dependent patients (due to the potential for electrical current transference to cardiac muscle) 3 6. Major complications following IRE for hepatic malignancy include bleeding, abscess, cholangitis, biliary occlusion and portal vein thrombosis 1 3 5 7 8…”

Section: Introductionmentioning

confidence: 99%

Needle tract seeding following percutaneous irreversible electroporation for hepatocellular carcinoma

Onafowokan

Carino

2022

BMJ Case Rep

View full text Add to dashboard Cite

Irreversible electroporation (IRE) is a non-thermal ablative technique for unresectable liver malignancies deemed unsuitable for traditional thermal ablation due to proximity to biliary and/or vascular structures. Needle tract tumour seeding is a well-recognised complication following thermal ablation, while little is known about its risk with IRE use. We present a case of tumour seeding after IRE for unresectable hepatocellular carcinoma in a man in his 70s. The procedure was complicated by bleeding from a pseudoaneurysm, which required coil embolisation and blood transfusion. He initially progressed well, however, imaging at 12 months indicated a new tumour in the right intercostal space along the tract of one of the IRE needles; consistent with seeding. Although the patient subsequently underwent systemic therapy with sorafenib, his disease progressed, and unfortunately he passed away 20 months following IRE. This report adds to mounting evidence of needle tract tumour seeding as a complication following IRE.

show abstract

The Effect of Irreversible Electroporation on Blood Vessels, Bile Ducts, Urinary Tract, Intestines, and Nerves

Cited by 7 publications

References 64 publications

Local Release of TGF‐β Inhibitor Modulates Tumor‐Associated Neutrophils and Enhances Pancreatic Cancer Response to Combined Irreversible Electroporation and Immunotherapy

Local Release of TGF‐β Inhibitor Modulates Tumor‐Associated Neutrophils and Enhances Pancreatic Cancer Response to Combined Irreversible Electroporation and Immunotherapy

Locally Advanced Pancreatic Cancer: Percutaneous Management Using Ablation, Brachytherapy, Intra-arterial Chemotherapy, and Intra-tumoral Immunotherapy

Needle tract seeding following percutaneous irreversible electroporation for hepatocellular carcinoma

Contact Info

Product

Resources

About