The effect of ischemic preconditioning on the course of polyneuropathy in vibration disease

Yamshchikova, A. V.; Fleishman, A. N.; Gidayatova, M. O.; Kungurova, Alla A.

doi:10.31089/1026-9428-2022-62-1-59-63

Med. tr. prom. èkol.

2022

DOI: 10.31089/1026-9428-2022-62-1-59-63

|View full text |Cite

The effect of ischemic preconditioning on the course of polyneuropathy in vibration disease

A. V. Yamshchikova¹,

A. N. Fleishman²,

M. O. Gidayatova³

et al.

Abstract: One of the primary syndromes of vibration disease is polyneuropathy, which is characterized primarily by the involvement of sensory fibers. In the clinical picture, such a lesion manifests itself in the form of sensitive disorders (pain, numbness, paresthesia), which worsen patients' quality of life. The neuroprotective effect of ischemic preconditioning is currently insufficiently studied and is a promising area of scientific research. The study aims to learn the effect of ischemic preconditioning of the uppe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Clinical manifestations and mechanisms of formation of neurological disorders in patients with vibration disease

Vorobieva,

Levchenkova

2023

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

The review presents an analysis of literature sources devoted to the study of changes in the nervous system in patients with vibration disease. Vibration-mediated cellular hypoxia, which occurs as a result of spastic changes in blood vessels, phase fluctuations in intravascular pressure, impaired blood and lymph outflow, causes suppression of energy metabolism, contributes to disorders at the level of receptor (glutamate, GABA-ergic, dopamine and cholinergic) and synaptic structures, conductors of pain and temperature sensitivity (demyelinization), analyzing neurons in the parietal region of the brain, regulatory proteins of the nervous tissue (NF-200, GFAP S-100). A low-amplitude, irregular, disorganized and sometimes deformed EEG spectrum with a predominance of the alpha wave and a shift of the alpha rhythm to the left reflects changes in the spontaneous electrical activity of brain structures in patients. With an increase in the experience dose of vibration-noise exposure, the dominant alpha activity changes to slow-wave or polyrhythmic. Mild and moderate diffuse changes in the brain become focal in nature, cortical-subcortical relationships are disrupted at the diencephalic level, creating a pathophysiological basis for sensorineural (sensory-neural) hearing loss, especially in patients with a genetic predisposition mediated by genes encoding proteins of the heat shock system. The psycho-emotional status of patients is characterized by a hypochondriacal focus on the state of health, mental disadaptation, psycho-emotional disorders in the form of anxiety, depressive mood. The analysis of literature sources on the mechanisms of the formation of neurological disorders in patients with vibration disease revealed the lack of data on the state of the multicomponent ghrelin system interacting with GHSR-1A and GHSR-1B receptors, which determines a new vector in further experimental and clinical studies.

show abstract

Clinical manifestations and mechanisms of formation of neurological disorders in patients with vibration disease

Vorobieva,

Levchenkova

2023

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

show abstract

Clinical effects of ischemic preconditioning in polyneuropathy of various origins

Yamshchikova,

Fleishman,

Martynov

et al. 2023

Hygiene and Sanitation

View full text Add to dashboard Cite

Introduction. Polyneuropathies are widespread among the population. Diabetes mellitus and industrial vibration are common causes of polyneuropathy, having common links of pathogenesis involving the autonomic nervous system. The therapeutic effects of ischemic preconditioning are realized by influencing pathogenetic mechanisms, and therefore their study in polyneuropathies of various genesis is of scientific interest. The aim of the study was to investigate the remote clinical effects of ischemic preconditioning in polyneuropathies of various genesis. Materials and methods. Twenty-five patients divided into 2 groups with lower extremity polyneuropathy of vibration and diabetic genesis were examined. A clinical and electroneuromyographic study of the peripheral nerves of the lower extremities was performed. An analysis of heart rate variability before and after the treatment with ischemic preconditioning of the upper extremities was executed. Results. In both groups of the patients with polyneuropathy a decrease in clinical manifestations in the form of pain syndrome and sensitive disorders (numbness and paresthesia), an improvement in vibration sensitivity, an increase in impulse conduction velocity, mainly along the peripheral sensory nerve fibers were revealed. The analysis of heart rate variability after performing of ischemic preconditioning showed a gaining of the power of very low frequency oscillations, which indicated to an increase in the compensatory capabilities of autonomic regulation. Limitations. The investigation was limited by studying the clinical and electrophysiological characteristics of the peripheral nervous system in 25 patients with diabetes mellitus type 2 and vibration disease caused by the exposure to local and whole-body vibration. Conclusion. After the course of treatment of the pain syndrome, sensitive and autonomic disorders decrease with an increase in the compensatory possibilities of autonomic regulation, the functions of conducting along sensory nerves improve. Positive distant effects of ischemic preconditioning in the correction of manifestations of vibration and diabetic polyneuropathies indicate to a systemic effect on the mechanisms of autonomic regulation. The distance is manifested in the remoteness of the appearance of effects from the place of application of the technique.

show abstract

Features of the use of ischemic preconditioning for the correction of vibration polyneuropathy of the upper extremities

Yamshchikova,

Fleishman,

Martynov

et al. 2023

Hygiene and Sanitation

View full text Add to dashboard Cite

Introduction. The study of the methods for non-pharmacological correction of vibration polyneuropathy is relevant in view of the high prevalence of vibration disease in various industries, and high occurrence of disability of workers. Ischemic preconditioning has shown its effectiveness in correcting the manifestations of vibration polyneuropathies. The high frequency of nerve compression in tunnels against the background of polyneuropathic lesions in vibration disease dictates the need to study the effectiveness of the method in various forms of vibration polyneuropathy. The aim of the study was to investigate the effectiveness of ischemic preconditioning in various forms of vibration polyneuropathy. Materials and methods. Twenty nine patients with a proven diagnosis of vibration disease were examined and treated uisng the ischemic preconditioning. They were divided into 2 groups: group 1 – 18 individuals with upper extremities polyneuropathy without nerve compression, group 2 – 11 subjects with compression complications of polyneuropathy. The examinations included neurological survey, electroneuromyographic investigation before and after the course of ischemic preconditioning conducted according to a patented technique. Results. A decrease in sensory disturbances and improvement in the impulse conduction along the sensory fibers of the nerves of the upper extremities after a course of ischemic preconditioning in the group of the patients without compression neuropathies were noted. In the group of the patients with polyneuropathies complicated by the nerve compression in tunnels, the positive effect was less significant. Limitations. The study was limited by the assessment of clinical and electroneuromyographic parameters in 29 patients with vibration disease due to the exposure to local vibration before and after the course of ischemic preconditioning. Conclusion. The method of ischemic preconditioning is effective as a method for non-pharmacological correction of vibration polyneuropathy. Compression neuropathies are predictors of lower efficiency of the method, and therefore it is important to select patients for the treatment by this method with the preferred inclusion of the patients with uncomplicated vibration polyneuropathies.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The effect of ischemic preconditioning on the course of polyneuropathy in vibration disease

Cited by 3 publications

References 15 publications

Clinical manifestations and mechanisms of formation of neurological disorders in patients with vibration disease

Clinical manifestations and mechanisms of formation of neurological disorders in patients with vibration disease

Clinical effects of ischemic preconditioning in polyneuropathy of various origins

Features of the use of ischemic preconditioning for the correction of vibration polyneuropathy of the upper extremities

Contact Info

Product

Resources

About