The effect of isomalathion and O,S,S-trimethyl phosphorodithioate on the in vivo metabolism of malathion in rats

Ryan, Declan; Fukuto, T. R.

doi:10.1016/0048-3575(84)90103-2

Cited by 10 publications

(1 citation statement)

References 23 publications

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“…Isomalathion and OSS are potent inhibitors of rat plasma, liver and kidney malathion carboxylesterases. In consequence less malathion diacid, but more amonoacid and malaoxon metabolites are excreted compared with control animals, suggesting an increased production of malaoxon in the presence of these impurities (Ryan and Fukuto 1984 Although they are poor AChE inhibitors and poor alkylating agents per se, trimethyl phosphorothioates have interesting toxicological properties of their own, producing delayed deaths in rats, associated with lung damage (Aldridge et al 1984).…”

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confidence: 96%

Insecticide metabolism and selective toxicity

Brooks

1986

Xenobiotica

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Current research is focused on means to improve the environmental acceptability and selective toxicity of existing classes of insecticides and the search for new and species selective modes of insecticidal action. The study of species differences in metabolism and its modulation by changes in chemical structure is a vital component of this effort. The importance of metabolism is illustrated by examples from the major classes of insect control chemicals, namely organophosphorus and carbamate insecticides, DDT, pyrethroids and insect growth regulators.

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confidence: 96%