The effect of isoproterenol on the catecholamine levels of peripheral tissues

Chronic Isoproterenol Treatment of Neonatal Rats

“…Growth stunting, premature opening of the eyes, and an increase of the ratio of heart weight to body weight have been reported following the chronic administration of isoproterenol to neonatal rats (5). Since acute and short-term treatment resulted in increased organ weights and derangements of catechol-amine levels (13)(14)(15)) and storage (15), and chronic isoproterenol treatment produced growth stunting and changes in organ weights in neonatal rats (5), the effects of chronic isoproterenol treatment on the tissue catecholamine levels, tissue weights, and rectal temperature were studied in neonatal rats and the results are reported in this paper. METHODS Animals-Two days after birth, Sprague-Dawley male and female rats from three litters were subcutaneously dosed with 0.85 % sodium chloride solution (controls) or 5 mg./kg.…”