The Effect of Isotretinoin on Ovarian Reserve Based on Hormonal Parameters, Ovarian Volume, and Antral Follicle Count in Women with Acne

Aksoy, Hüseyin; Çınar, Salih Levent; Açmaz, Gökhan; Aksoy, Ülkü; Aydin, Turgut; Vurdem, Ümit Erkan; Öz, Leyla; Karadağ, Özay; Kartal, Demet

doi:10.1159/000371551

Cited by 20 publications

(13 citation statements)

References 18 publications

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“…Sample size reference values (means, standard deviations, and reference sample sizes) were obtained from patient data observed by the authors. Taking into account all these results, our need for a total sample size is 40 for comparison [16]. The analysis was made using G ∗ Power 3.1.7.…”

Section: Power Analysismentioning

confidence: 99%

The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

Açmaz

Çınar

Acmaz

et al. 2019

BioMed Research International

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Introduction. Many patients who were diagnosed as polycystic ovary syndrome- (PCOS-) related acne were not capable of sustaining or beginning oral contraceptive pills (OCPs) due to pill scaring, contraindications of OCP use, migraine, or smoking. In this situation, oral isotretinoin treatment may become an important option for PCOS-related acne. The aim of the study was to determine the effects of isotretinoin treatment on PCOS patients who were complicated with severe cystic acne. Materials and Methods. This study consisted of 40 female patients diagnosed as PCOS complicated with severe cystic acne. These patients were not eligible candidates for OCP use due to migraine, thrombophilia, heavy smoking, or pill scare. To establish baseline values of hormone levels, on days 2–5 of the menstrual cycle, venous blood samples were obtained. Moreover Modified Ferriman-Gallwey (mFG) score, acne score (AS), follicle count, and bilateral ovarian volumes were evaluated both before and after isotretinoin treatment. Results. Isotretinoin treatment significantly decreased Ferriman-Gallwey score, free testosterone, insulin level, hemoglobin level, acne score, and ovarian volume. Increased triglyceride and cholesterol levels were detected after treatment. Conclusion. Isotretinoin treatment may have beneficial effects on free testosterone, insulin, acne score, and Ferriman-Gallwey score. Solely isotretinoin administration may supply adequate healing in PCOS patients’ symptoms complicated with severe cystic acne who is not eligible candidates for OCP use. This trial is registered with Clinicaltrials.gov NCT02855138.

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Section: Power Analysismentioning

confidence: 99%

The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

Açmaz

Çınar

Acmaz

et al. 2019

BioMed Research International

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“…Isotretinoin is thought to have no side effects on male fertility, but impaired spermatogenesis findings have been reported in several animal experiments using isotretinoin administration [9]. However, several clinical studies investigating the effects of isotretinoin on female fertility have been reported to reduce ovarian reserves [10][11][12]. Similar data have been reported in animal studies in which rats were treated with 7.5 and 15 mg/kg/day isotretinoin [13,14].…”

Section: Introductionmentioning

confidence: 68%

“…In a human study, it was reported that serum AMH levels at the end of treatment of women with acne who underwent isotretinoin treatment decreased compared to serum AMH levels at the beginning of treatment, and this reduction in AMH levels has been reported to be associated with the side effect of isotretinoin on ovarian reserve [10]. In another human study, the effect of orally used isotretinoin on ovarian reserve in reproductive age women was investigated [11]. As a result of this study, when serum AMH level, ovarian volume, and antral follicles were compared before and after treatment, a significant decrease was found in posttreatment findings.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Isotretinoin on Oocyte Maturation in Adolescent Female Rats

Kacamak

Özoğul

Saribas

et al. 2020

Gynecol Obstet Invest

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Objective: Isotretinoin is used in acne vulgaris treatment for more than 20 years. Isotretinoin has serious side effects on many organs, but there are no comprehensive studies investigating its possible toxic effects on reproductive organs. Thus, we aimed to investigate the possible toxic effects of isotretinoin administration on oocyte maturation in female rat gonads in this study. Methods: Thirty-two adolescent female rats (Wistar Albino, 220 ± 35 g) were randomly divided into 4 groups with 8 subjects in each group: group 1, group 2, group 3, and group 4. Different doses of isotretinoin which was dissolved in sesame oil were given to rats by gavage: 7.5 mg/kg/day in group 3 and 15 mg/kg/day in group 4. The rats in group 2 received sesame oil by gavage. To create gavage stress, only gavage was administered to the rats in group 1. The gavages for each group continued once a day and at a certain time for 30 days. To determine the effect of isotretinoin on oocyte maturation, the periodic acid-Schiff reaction was performed for histochemical and histomorphometric evaluation of the zona pellucida, and staining of growth differentiation factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15) was performed for immunohistochemical analysis. Results: When the thickness of the zona pellucida was evaluated, a statistically significant difference was found between group 1 and experimental groups (group 3 and group 4). In the experimental groups, it was determined that the thickness of the zona pellucida was decreased depending on the increase in dose. GDF-9 and BMP-15 expressions in oocytes of primordial and primary follicles decreased significantly in the experimental groups compared to group 1 and group 2. However, the expression of GDF-9 and BMP-15 in oocytes of secondary follicles was not significantly different between group 1 and group 2 and the experimental groups. Conclusions: In our study, we showed toxic effect of isotretinoin on oocyte maturation in female rats.

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“…Studies report that OIT has no impact in ovarian function. None of the studies has shown long‐term infertility (Aksoy et al, ; Öztürk et al, ). The patients were told about these two different concepts before starting OIT.…”

Section: Discussionmentioning

confidence: 99%

Perceptions about oral isotretinoin treatment

Ayanoğlu

Demirdağ

Yalıcı-Armağan

et al. 2019

Dermatologic Therapy

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There are some studies on the knowledge, beliefs, and perceptions of patients about acne vulgaris, however, there is no sufficient data on patients' beliefs about oral isotretinoin treatment (OIT). The aim of this study was to assess the knowledge, beliefs, and perceptions of the patients with acne vulgaris about the therapy of OIT and its side effects. A total of 214 patients with acne vulgaris in our outpatient clinic were included. Patients who were planned to treat with OIT were asked whether they had information about the treatment and its side effects. It was noted whether the patients accepted treatment after being informed both verbally and written about the OIT details. The study consisted of 133 female and 81 male aged 12–57 years. Most of the patients (78%) stated that they had heard of OIT. The most common source of the information on isotretinoin therapy was friends (57.6%). The dryness was the best‐known side effect. While 86.4% of patients (n: 185) accepted OIT, the group (14.4%) stated that “I have knowledge about side effects.” And refused to use the treatment. Most of the patients agreed to the treatment after explanation of dermatologist. Patients may be educated and informed via reliable medical sources to prevent bias and improve compliance to the treatment.

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The Effect of Isotretinoin on Ovarian Reserve Based on Hormonal Parameters, Ovarian Volume, and Antral Follicle Count in Women with Acne

Cited by 20 publications

References 18 publications

The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

The Effect of Isotretinoin on Oocyte Maturation in Adolescent Female Rats

Perceptions about oral isotretinoin treatment

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