The Effect of Jackfruit (Artocarpus heterophyllus Lam.) Seed Ethanol Extract on Blood Sugar Levels and Anti-Inflammatory Reduction on Wistar Albino Rats Streptozotocin-Induced Gestational Diabetes

Abstract

Gestational Diabetes Mellitus is a disorder of carbohydrate tolerance that results in increased blood sugar levels and was first recognised during the second and third trimesters of pregnancy. It is a health problem that has a direct impact on the health of the mother and fetus. The purpose of this study was to analyse the effect of jackfruit (Artocarpus heterophyllus Lam.) Seed Ethanol Extract on reducing Blood Sugar Levels and Inflammation in Wistar Albino Rats with Gestational Diabetes Mellitus induced by Streptozotocin. This study used a laboratory experimental research design with a post-test only control group design on Wistar Albino Rats with Gestational Diabetes Mellitus. The sample was obtained by the simple random sampling method. The results showed that the lowest spectrophotometer KGD level was in group C given Streptozotocin 45mg/kg BW + Metformin 45mg/kg BW with a p value of 0.003, which means there was a significant difference between groups and the lowest Interleukin-6 level. In group C, they were given Streptozotocin 45mg/kg BW + Metformin 45mg/kg BW with a p value of 0.511, meaning there was no significant difference between groups. Jackfruit seed ethanol extract functions as a lowering of blood sugar levels and an anti-inflammatory.