The effect of ketamine hydrochloride anesthesia on basal and N-methyl-D,L-aspartate induced plasma prolactin secretion in the adult male rhesus monkey

Rizvi, Syed Shakeel Raza; Altaf, Sadaf; Naseem, Abbas Ali; Asif, Mohammad; Rasul, Zahid; Qayyum, Mazhar

doi:10.1016/s0024-3205(00)01010-9

Cited by 9 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results with the anesthetics ketamine and isoflurane are very similar to those of previous studies, showing an initial rise in prolactin levels followed by a gradual decline (Reber et al 1998;Puri et al 1981;Rizvi et al 2001;Hergovich et al 2001). Prior studies suggest that isoflurane may produce a larger prolactin response than ketamine, though the data are from different species and sex.…”

Section: Anesthetic Effects On Prolactinsupporting

confidence: 88%

“…Prior studies suggest that isoflurane may produce a larger prolactin response than ketamine, though the data are from different species and sex. Isoflurane in human females has shown a 9 to 12-fold increase in prolactin (Reber et al 1998;Marana et al 2003), while ketamine produced a 2-to 4-fold increase in male macaques after a single injection (Puri et al 1981;Rizvi et al 2001). A study in adult baboon females found no significant difference in PRL release between constant-rate i.v.…”

Section: Anesthetic Effects On Prolactinmentioning

confidence: 99%

“…First we charted the effects of ketamine and isoflurane on prolactin secretion over time without administering a dopamine agonist, since both these anesthetic agents increase plasma prolactin levels (Wickings & Nieschlag 1980;Puri et al 1981;Crozier et al 1994;Hergovich et al 2001;Rizvi et al 2001). We took a blood sample as soon as possible after giving ketamine, with the expectation that circulating prolactin concentrations would not change for >20 minutes after i.m.…”

Section: Anesthesia Alonementioning

confidence: 99%

“…We took a blood sample as soon as possible after giving ketamine, with the expectation that circulating prolactin concentrations would not change for >20 minutes after i.m. ketamine (Rizvi et al 2001). The goal was to determine when the effects of ketamine and/or isoflurane on prolactin release would reach an approximate steady state.…”

Section: Anesthesia Alonementioning

confidence: 99%

See 3 more Smart Citations

Prolactin and fMRI response to SKF38393 in the baboon

Miller

Marks

Koller

et al. 2013

Preprint

View full text Add to dashboard Cite

Background: This study's goal was to provide dose-response data for a dopamine agonist in the baboon using standard methods (replicate measurements at each dose, across a range of doses), as a standard against which to subsequently validate a novel pharmacological MRI (phMRI) method.Dependent variables were functional MRI (fMRI) data from brain regions selected a priori, and systemic prolactin release. Necessary first steps included estimating the magnitude and time course of prolactin response to anesthesia alone and to various doses of agonist. These first steps ("time course studies") were performed with three agonists, and the results were used to select promising agonists and to guide design details for the single-dose studies needed to generate dose-response curves. Methods:We studied 6 male baboons (Papio anubis) under low-dose isoflurane anesthesia after i.m.ketamine. Time course studies charted the changes in plasma prolactin levels over time after anesthesia alone or after an intravenous (i.v.) dose of the dopamine D 1 -like agonists SKF82958 and SKF38393 or the D 2 -like agonist pramipexole. In the single-dose dopamine agonist studies, one dose of SKF38393 (ranging from 0.0928 -9.28 mg/kg, N=5 animals) or pramipexole (0.00928 -0.2 mg/kg, N=1) was given i.v. during a 40-minute blood oxygen level dependent (BOLD) fMRI session, to determine BOLD and plasma prolactin responses to different drug concentrations. BOLD response was quantified as the area under the time-signal curve for the first 15 minutes after the start of the drug infusion, compared to the linearly predicted signal from the baseline data before drug. The ED 50 (estimated dose that produces 50% of the maximal possible response to drug) for SKF38393 was calculated for the serum prolactin response and for phMRI responses in hypothalamus, pituitary, striatum and midbrain. Results: Prolactin rose 2.4-to 12-fold with anesthesia alone, peaking around 50-90 minutes after ketamine administration and gradually tapering off but still remaining higher than baseline on isoflurane 3-5 hours after ketamine. Baseline prolactin level increased with age. SKF82958 0.1mg/kg i.v. produced no noticeable change in plasma prolactin concentration. SKF38393 produced a substantial increase in prolactin release that peaked at around 20-30 minutes and declined to pre-drug levels in about an hour. Pramipexole quickly reduced prolactin levels below baseline, reaching a nadir 2-3 hours after infusion. SKF38393 produced clear, dose-responsive BOLD signal changes, and across the four regions, ED 50 was estimated at 1.6-7.7mg/kg.Conclusions: In the baboon, the dopamine D 1 receptor agonist SKF38393 produces clear plasma prolactin and phMRI dose-response curves.Variability in age and a modest sample size limit the precision of the conclusions. PrePrints peaked at around 20-30 minutes and declined to pre-drug levels in about an hour. PeerJ PrePrintsPramipexole quickly reduced prolactin levels below baseline, reaching a nadir 2-3 hours after infusion. SKF38393 produced clear,...

show abstract

Section: Anesthetic Effects On Prolactinsupporting

confidence: 88%

Section: Anesthetic Effects On Prolactinmentioning

confidence: 99%

Section: Anesthesia Alonementioning

confidence: 99%

Section: Anesthesia Alonementioning

confidence: 99%

See 2 more Smart Citations

Prolactin and fMRI response to SKF38393 in the baboon

Miller

Marks

Koller

et al. 2013

Preprint

View full text Add to dashboard Cite

show abstract

“…Os aminoácidos excitatórios como glutamato e aspartato, agindo predominantemente com receptores N-metil-D-aspartato (NMDA), estão envolvidos na regulação central da secreção de vários hormônios pituitários anteriores inclusive prolactina (PRL), considerando que a ketamina, um anestésico extensamente usado, foi indicado para antagonizar uma variedade de receptores NMDA mediados por estes aminoácidos excitatórios (RIZVI et al, 2000).…”

Section: Sistema Nervoso Central (Snc)unclassified

Contenção farmacológica em primatas não-humanos com emprego de ketamina e xilazina. Uma revisão bibliográfica

Miranda¹,

Cabala²,

Atan³

et al. 2011

Pubvet

View full text Add to dashboard Cite

Novel Application of Nonhuman Primate Tethering System for Evaluation of Acute Phase SIVmac251 Infection in Rhesus Macaques (Macaca mulatta)

et al. 2007

View full text Add to dashboard Cite

Infection of rhesus macaques with simian immunodeficiency virus (SIV) is the preferred animal model for the development and testing of human immunodeficiency virus (HIV) vaccines, and animals protected from SIV challenge by live attenuated vaccines are an invaluable tool for determining immune correlates of protection. The acute phase of SIV infection, in which immune responses are most critical for slowing disease progression, occurs within the first 4 weeks of exposure. The small window of time available for observing critical immune responses makes obtaining adequate blood samples with sufficient frequency difficult. This study is the first to apply a previously reported nonhuman primate (NHP) tether system to study viral immunology. The use of the tether allows for frequent blood sampling without using restraints or sedation, thereby reducing the potentially confounding physiological changes induced by stress. We performed comparative analysis of acute phase immune responses in vaccinated and unvaccinated animals challenged with SIV-mac251. Our results demonstrate live attenuated vaccine-induced protection, which is associated with small increases in the cytotoxic T-cell (CTL) response to immunodominant epitopes, but not with increases in antibody titers. Additionally, vaccination was shown to establish a pool of antigen-specific CD8+ memory cells available for expansion after challenge. The confirmatory nature of these data indicates the validity of using the tether system for evaluation of acute phase anti-SIV responses and can be applied to the study of immune responses in other viral infections in which frequent sampling in small windows of time would be useful.

show abstract

The effect of ketamine hydrochloride anesthesia on basal and N-methyl-D,L-aspartate induced plasma prolactin secretion in the adult male rhesus monkey

Cited by 9 publications

References 0 publications

Prolactin and fMRI response to SKF38393 in the baboon

Prolactin and fMRI response to SKF38393 in the baboon

Contenção farmacológica em primatas não-humanos com emprego de ketamina e xilazina. Uma revisão bibliográfica

Novel Application of Nonhuman Primate Tethering System for Evaluation of Acute Phase SIVmac251 Infection in Rhesus Macaques (Macaca mulatta)

Contact Info

Product

Resources

About