The effect of ketamine on intraspinal acetylcholine release: Involvement of spinal nicotinic receptors

Abelson, Klas S P; Goldkuhl, Renée; Nylund, Anders; Höglund, A. Urban

doi:10.1016/j.ejphar.2006.01.044

Cited by 18 publications

(8 citation statements)

References 38 publications

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“…The antinociceptive effects of systemic ketamine are considered to be mediated in spinal cord and supraspinal sites (Christoph et al. 2006; Abelson et al. 2006; Koizuka et al.…”

Section: Discussionmentioning

confidence: 99%

“…Although systemic ketamine has been used in the clinical and animal studies, the underlying analgesic mechanism is still controversial. The antinociceptive effects of systemic ketamine are considered to be mediated in spinal cord and supraspinal sites (Christoph et al 2006;Abelson et al 2006;Koizuka et al 2005;Kawamata et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Lots of studies have been carried out to center its underlying analgesic mechanisms which are still mysterious. Besides the possible involvement of its major target molecule NMDA receptor (Christoph et al 2006;Hota et al 2007), previous studies have indicated that the monoaminergic descending inhibitory system, opioid receptors, nicotinic receptors, voltage-gated ion channels, and even the GABA receptor are active partitioners for ketamine analgesia (Schnoebel et al 2005;Koizuka et al 2005;Nadeson et al 2002;Abelson et al 2006;Hevers et al 2008). These explanations focus on the effects of ketamine on the neuronal elements while neglecting the possible contribution of their glial partners.…”

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confidence: 99%

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Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level?

Mei

Wang

et al. 2009

Journal of Neurochemistry

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Although ketamine is widely used as an analgesic agent and has an anti‐allodynic effect on neuropathic pain, the underlying analgesic mechanisms are not fully explained by the modern ‘neuronal‐based’ theories. As emerging studies have focused on the critical role of spinal astrocytes in the pathological pain states, we have hypothesized that there exist some ‘astrocytes‐related’ mechanisms in the analgesic function of ketamine. In the present study, using the spinal nerve ligation (SNL) pain model, we investigated the anti‐nociceptive effects of intraperitoneal or intrathecal ketamine on SNL‐induced neuropathic pain response, meanwhile, we investigated the astrocytic activation after ketamine administration on SNL rats. Behavioral data showed that either intraperitoneal or intrathecal ketamine inhibited SNL‐induced allodynia, however, immunohistochemistry showed that SNL induced astrocytic activation was suppressed by intrathecal but not intraperitoneal ketamine. Using quantitative Western blot analysis, our report showed that intrathecal ketamine down‐regulated glial fibrillary acidic protein expression, suggesting inhibition of SNL‐induced astrocytic activation, which wasn’t influenced by intraperitoneal administration. We conclude that intraperitoneal ketamine could alleviate SNL‐induced neuropathic pain via the classical ‘neuronal‐based’ mechanisms, but in addition, ‘astrocytes‐related’ mechanisms were also important underlying the anti‐allodynic effect of intrathecal ketamine.

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“…The antinociceptive effects of systemic ketamine are considered to be mediated in spinal cord and supraspinal sites (Christoph et al. 2006; Abelson et al. 2006; Koizuka et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level?

Mei

Wang

et al. 2009

Journal of Neurochemistry

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“…Yet another mechanism in the pain system where ketamine effects were explored was serotonin uptake. Ketamine was reported to inhibit this uptake . The monoamines serotonin and norepinephrine are thought to be the principal mediators of endogenous descending pain inhibition .…”

Section: Analgesic Mechanismsmentioning

confidence: 99%

Ketamine in Pain Management

Persson

2013

CNS Neurosci Ther

101

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SUMMARYFor ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented. Its history is traced from its conception, and its heritage, as a phencyclidine offspring, delineated. The earliest roots of the conceptions concerning the mechanisms of action are sought, and then followed in preclinical as well as clinical research. The major proposed mechanisms in the literature are commented on and evaluated. The growth of the clinical evidence for perioperative pain, acute pain, and chronic pain is followed from early attempts to systematic reviews. Finally, an attempt is made to foresee what the next 50 years might hold in store for our 50 years old.

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“…This enables in vivo sampling of neurotransmitters from a large surface of the dorsal spinal cord, as well as administration of substances to the same area. The usefulness of the spinal loop dialysis probe for this purpose has been shown in numerous studies carried out in our laboratory [8–17]. However, the technique is still not fully evaluated and more studies must be undertaken to develop the methodology into a more reliable tool for pharmacological research.…”

mentioning

confidence: 99%

Drug Distribution in Spinal Cord during Administration with Spinal Loop Dialysis Probes in Anaesthetized Rats

Uustalu

Abelson

2007

Basic Clin Pharma Tox

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The present investigation aimed to study two methodological concerns of an experimental model, where a spinal loop dialysis probe is used for administration of substances to the spinal cord and sampling of neurotransmitters by microdialysis from the same area of anaesthetized rats. 3 H]epibatidine was found to be distributed to the area closest to the dialysis probe and not dispersed along the spinal cord, and the distribution was equal for all concentrations. The data presented in this investigation provide information, which is important for interpretation of data from intraspinal administration of substances through the spinal loop dialysis probe.

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The effect of ketamine on intraspinal acetylcholine release: Involvement of spinal nicotinic receptors

Cited by 18 publications

References 38 publications

Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level?

Inhibiting astrocytic activation: a novel analgesic mechanism of ketamine at the spinal level?

Ketamine in Pain Management

Drug Distribution in Spinal Cord during Administration with Spinal Loop Dialysis Probes in Anaesthetized Rats

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