The effect of ketoprofen in chronic periodontitis: A clinical double-blind study

Abstract

Background:The objective of this double-blind clinical trial was to evaluate the effects of the nonsteroidal anti-inflammatory drug (NSAID), ketoprofen, on patients with chronic periodontitis.Materials and Methods:Two similar local drug delivery preparations of a poloxamen gel containing 1.5% ketoprofen and a placebo were indigenously prepared for this purpose. Ten subjects aged 33-55 years with moderate to severe chronic periodontitis were recruited and were monitored for a period of 90 days. Three sites in each patient (total 30 sites) with a probing pocket depth of 5-8 mm were selected and divided randomly into three groups: 1) group A: scaling and rootplaning (SRP) + drug A; 2) group B: SRP + drug B; and 3) group C: SRP. Clinical parameters and blood smear (from intracrevicular blood) were assessed to determine the differential count and Arneth index. All parameters were assessed at baseline, 30 days and 90 days, respectively.Results:Highly significant values were achieved for plaque index (P=0.00), and significant values were obtained for gingival index (P=0.044). Reduction in bleeding on probing was found to be highly significant. Probing depth and clinical attachment level showed no inter group variation.Conclusion:The results of this double-blind trial indicate that the combined effect of locally delivered ketoprofen with SRP was more effective in controlling periodontal disease than SRP alone.

The Effects of Prednisone/Ketoprofen Administration in Association with Amoxicillin Clavulanate Following Periodontal Surgical Therapy in Patients with Severe Chronic Periodontitis

“…A clinical study retrieved from the literature assessed BOP in two groups of patients with periodontitis, one systemically healthy and one using SAIDs for general chronic inflammation, and found comparable results [ 24 ]. On the other hand, some clinical studies evaluating NSAIDs’ effects on inflammation parameters in patients with chronic periodontitis showed a significant BOP reduction [ 25 , 26 ]. Other previous studies evaluated NSAIDs’ effects on marginal periodontium, being performed without clinical evaluations of periodontal inflammation.…”

A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial

“…Morphine-containing mouthwash (Ikeuchi-Takahashi, Sasatsu, and Onishi 2013; Potrč et al 2015;Zhou et al 2015) and doxepin-contained mouthwash are also recommended for analgesic effects (Epstein et al 2006(Epstein et al , 2008. Some treatments are recommended to the patients to accelerate wound healing, for instance, sulfate contained mouthwash and capsules (Gilhotra et al 2014), antioxidants derived from plants (Chou et al 2016), and low-level laser therapy (Srinivas et al 2011). In case of failure of topical medication, systemic medication such as morphine and fentanyl has been suggested (Tungprapa, Jangchud, and Supaphol 2007).…”