“…We agree with the authors statement that NSAIDs significantly reduce pain after acute fractures and postoperatively because of their regional analgesic and anti-inflammatory action in addition to their analgesic effect on the central nervous system (Prados and Baylock 1991). Some evidence also suggests that when NSAIDs are used in combination with opioid analgesics, they can help to reduce the amount of opioids needed without affecting the degree of analgesia (Prados and Baylock 1991). However, this reduction in the amount of the opioid seems not to reduce the opioid-related side effects such as nausea or respiratory depression (Sevarino et al 1992).…”