The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais

Chaisri, Suwit; Jumnainsong, Amonrat; Romphruk, Amornrat; Leelayuwat, Chanvit

doi:10.1007/s00430-020-00685-z

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…It has been proposed that at the beginning of the dengue infection, there is an increase in the presentation of NS1 by HLA-B27, expressed on the surface of the infected cell, and the interaction of the NS1-HLA-B27 complex with KIR3DL1 causes the inhibition of NK. 40 In patients with dengue, Chaisri et al 19 indicated susceptibility of HLA-A*11 in the development of the disease. In addition to the interaction with KIRs, studies indicate that HLA-A*24 and HLA-B*44 , variants of the HLA-Bw4 ligand, with the respective T cell responses are related to susceptibility to dengue hemorrhagic fever.…”

Section: Discussionmentioning

confidence: 99%

“…(14) The KIR genes and their HLA class I ligands are associated with diseases caused by flaviviruses, such as dengue and West Nile viruses. (15,16,17,18,19) To date, the influence of KIR genes and their HLA class I ligands on patients affected by ZIKV has not been evaluated yet. By investigating the KIR-HLA association, we might better understand the genetic susceptibility involved in ZIKV infection.…”

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confidence: 99%

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Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil

Elpidio

Moraes

Langer³

et al. 2022

Mem. Inst. Oswaldo Cruz

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BACKGROUND Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV. During ZIKV infection, cytokines are produced and natural killer (NK) cells are recruited, whose activation depends on signaling pathways activated by specific receptors, such as killer cell immunoglobulin-like receptors (KIR). These molecules interact with human leukocyte antigen (HLA) class I ligands and are encoded by polymorphic genes. OBJECTIVES This study aimed to evaluate the frequency of allelic variants of the genes encoding the KIR receptors and their HLA class I ligands in 139 symptomatic ZIKV-patients and 170 controls negative for the virus, and to evaluate the role of these variants for ZIKV susceptibility. METHODS KIR and HLA class I genes were genotyped using the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique. FINDINGS No significant differences in the frequency distribution of KIRs and KIR-HLA in patients compared to controls were observed. MAIN CONCLUSIONS KIR and its HLA ligands might play a minor role in ZIKV infection in the south and southeast Brazilian individuals.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil

Elpidio

Moraes

Langer³

et al. 2022

Mem. Inst. Oswaldo Cruz

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“…Additional HLA typing and statistical inference of HLA alleles can refine the SNP association signals to specific HLA alleles, reflecting specific molecular functions and pathways. Such a strategy was successfully implemented for infectious diseases such as HIV, HPV, Dengue, and Ebola ( Lin et al, 2003 ; Wang et al, 2011 ; Nishida et al, 2016 ; Adebamowo and Adeyemo, 2019 ; Chen et al, 2019 ; Ekenberg et al, 2019 ; Butler-Laporte et al, 2020 ; Chaisri et al, 2020 ; Huang et al, 2020 ; Ursu et al, 2020 ; Yengo et al, 2020 ).…”

Section: The Role Of Immunogenetics In Infectious Diseasesmentioning

confidence: 99%

Current HLA Investigations on SARS-CoV-2 and Perspectives

et al. 2021

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The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.

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“…Although these authors did not analyze KIR haplotypes, these data suggest that tAB1 without its ligand or centromeric AB1 (cAB1) with its ligand are associated with ICU admission during H1N1 infection (Ahlenstiel et al ( 2008 ); La et al ( 2011 ). However, tAB1 with its ligand is protective against dengue fever (Chaisri et al 2020 ). Likewise, the protective genotypes suggested by Jiang et al ( 2013 ) and Shan et al ( 2018 ) may correlate with tAB1 and cAA motifs along with their ligands and may therefore be associated with the reduced severity of HIV and HCV infections, respectively.…”

Section: Introductionmentioning

confidence: 99%

A model integrating Killer Immunoglobulin-like Receptor (KIR) haplotypes for risk prediction of COVID-19 clinical disease severity

et al. 2021

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Graphical abstract Associations between inherited Killer Immunoglobulin-like Receptor (KIR) genotypes and the severity of multiple RNA virus infections have been reported. This prospective study was initiated to investigate if such an association exists for COVID-19. In this cohort study performed at Ankara University, 132 COVID-19 patients (56 asymptomatic, 51 mild-intermediate, and 25 patients with severe disease) were genotyped for KIR and ligands. Ankara University Donor Registry (n:449) KIR data was used for comparison. Clinical parameters (age, gender, comorbidities, blood group antigens, inflammation biomarkers) and KIR genotypes across cohorts of asymptomatic, mild-intermediate, or severe disease were compared to construct a risk prediction model based on multivariate binary logistic regression analysis with backward elimination method. Age, blood group, number of comorbidities, CRP, D-dimer, and telomeric and centromeric KIR genotypes (tAA, tAB1, and cAB1) along with their cognate ligands were found to differ between cohorts. Two prediction models were constructed; both included age, number of comorbidities, and blood group. Inclusion of the KIR genotypes in the second prediction model exp (-3.52 + 1.56 age group - 2.74 blood group (type A vs others) + 1.26 number of comorbidities - 2.46 tAB1 with ligand + 3.17 tAA with ligand) increased the predictive performance with a 92.9% correct classification for asymptomatic and 76% for severe cases (AUC: 0.93; P < 0.0001, 95% CI 0.88, 0.99). This novel risk model, consisting of KIR genotypes with their cognate ligands, and clinical parameters but excluding earlier published inflammation-related biomarkers allow for the prediction of the severity of COVID-19 infection prior to the onset of infection. This study is listed in the National COVID-19 clinical research studies database.

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The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais

Cited by 8 publications

References 41 publications

Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil

Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil

Current HLA Investigations on SARS-CoV-2 and Perspectives

A model integrating Killer Immunoglobulin-like Receptor (KIR) haplotypes for risk prediction of COVID-19 clinical disease severity

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