The effect of L‐arginine supplementation on maximal oxygen uptake: A systematic review and meta‐analysis

Rezaei, Shahla; Tabrizi, Reza; Nowrouzi-Sohrabi, Peyman; Rastgoo, Samira

doi:10.14814/phy2.14739

Cited by 12 publications

(9 citation statements)

References 34 publications

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“…This observation suggests that redox balance in a cell has a positive effect on the abovementioned molecular pathways, potentially indicating a regulatory role of redox balance in various cellular and metabolic pathways. VO2max was correlated with L-arginine biosynthesis in males, which fits well with the result of the study which reported increased VO2max after L-arginine supplementation (Rezaei et al, 2021).…”

Section: Discussionsupporting

confidence: 90%

Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

Torma,

Kerepesi,

Jókai

et al. 2024

Aging Cell

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Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.

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Section: Discussionsupporting

confidence: 90%

Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

Torma,

Kerepesi,

Jókai

et al. 2024

Aging Cell

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“…Arginine, which is present in Maca, affects endurance and heart (25). Rezaei et al reported that meta-analysis indicated that supplementation with arginine could increase VO2 max in healthy people (26). Speer et al also support the fact that the combination of arginine and citrulline might increase nitric oxide production and enhance vasodilation, thereby improving athletes' performance (27).…”

Section: Discussionmentioning

confidence: 99%

Effects of Black Maca supplement on isokinetics muscular performance of elite women’s handball players: placebo-controlled, crossover study

Kang,

Ahn,

Park

et al. 2023

Food & Nutrition Research

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Background: The aim of this study was to investigate the changes in isokinetic muscular performance among female adolescent elite handball athletes with the supplementation of Black Maca (BM). Methods: Eight elite handball athletes were recruited for the present study. The intake capsules contained 2,500 mg of 100% concentrated BM extract and a placebo each, for 4 weeks. Isokinetic muscular performance and physical fitness were measured three times at 4-week intervals after the intake of BM and placebo, including baseline. Results: The one-way Analysis of Variance (ANOVA) analysis showed a significant improvement in 20 m-shuttle run (P < 0.001), 30°/s flexor (P < 0.01), and 120°/s flexor (P < 0.01) in isokinetic muscle function of the trunk, and 180°/s right extensor (P < 0.05), 180°/s left extensor (P < 0.05), and 180°/s left flexor (P < 0.01) in isokinetic muscle function of the knee, after BM supplementation. Post-hoc analysis indicated that the BM group had significantly higher results compared to the baseline and placebo groups in terms of 20 m-shuttle run, 30°/s flexor and 120°/s flexor of the trunk, 180°/s right extensor, 180°/s left extensor, and 180°/s left flexor of the knee. Conclusion: BM supplementation can have a positive effect on improving the performance of elite handball players who engage in high-intensity movements by enhancing their isokinetic muscle function and endurance.

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“…8 f). l -Arg plays a positive regulatory role in the bioavailability of nitric oxide, which is beneficial for improving coronary perfusion and cardio-pulmonary function 33 . During strenuous exercise, l -Arg up-regulated the utilization of glucose and lipid through PI3K/Akt signal pathway and mediate myocardial oxidative stress by cleaning ROS and enhancing antioxidant enzymes activity 34 , 35 .…”

Section: Discussionmentioning

confidence: 99%

Effect of acute high-intensity exercise on myocardium metabolic profiles in rat and human study via metabolomics approach

Wang

Cao

et al. 2022

Sci Rep

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Acute high-intensity exercise can affect cardiac health by altering substance metabolism. However, few metabolomics-based studies provide data on the effect of exercise along with myocardial metabolism. Our study aimed to identify metabolic signatures in rat myocardium during acute high-intensity exercise and evaluate their diagnostic potential for sports injuries. We collected rat myocardium samples and subjects’ serum samples before and after acute high-intensity exercise for metabolite profiling to explore metabolic alterations of exercise response in the myocardium. Multivariate analysis revealed myocardium metabolism differed before and after acute high-intensity exercise. Furthermore, 6 target metabolic pathways and 12 potential metabolic markers for acute high-intensity exercise were identified. Our findings provided an insight that myocardium metabolism during acute high-intensity exercise had distinct disorders in complex lipids and fatty acids. Moreover, an increase of purine degradation products, as well as signs of impaired glucose metabolism, were observed. Besides, amino acids were enhanced with a certain protective effect on the myocardium. In this study, we discovered how acute high-intensity exercise affected myocardial metabolism and exercise-related heart injury risks, which can provide references for pre-competition screening, risk prevention, and disease prognosis in competitive sports and effective formulation of exercise prescriptions for different people.

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The effect of L‐arginine supplementation on maximal oxygen uptake: A systematic review and meta‐analysis

Cited by 12 publications

References 34 publications

Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness

Effects of Black Maca supplement on isokinetics muscular performance of elite women’s handball players: placebo-controlled, crossover study

Effect of acute high-intensity exercise on myocardium metabolic profiles in rat and human study via metabolomics approach

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