The Effect of L-Carnitine Supplementation on Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Role of Carnitine in Non-alcoholic Fatty Liver Disease and Other Related Diseases: An Update

“…Carnitine, a natural compound closely related to the above-mentioned functions, has recently been found to alter the underlying disease pathology with fewer side effects ( 5 , 36 ). It has been reported that L-carnitine as a supplement can be useful in the treatment of hypertension ( 37 ), diabetes mellitus ( 6 , 7 ), NAFLD ( 34 ), heart failure ( 38 ), coronary artery disease ( 39 ), liver cirrhosis ( 40 ), muscle injury ( 41 ), dyslipidemia ( 42 ), migraine ( 43 ), Alzheimer's disease ( 44 ), and other chronic diseases.…”

A Multi-Ingredient Formula Ameliorates Exercise-Induced Fatigue by Changing Metabolic Pathways and Increasing Antioxidant Capacity in Mice

“…The multi-ingredient formula containing valine, isoleucine, leucine, β-alanine, creatine, l -carnitine, quercetin, and betaine was pre-mixed and then suspended in the 0.5% CMC-Na solution (CMC-Na: distilled water = 0.5:100, w / v ). The total daily dose of each component was 125 mg/kg, 125 mg/kg, 250 mg/kg, 182 mg/kg, 250 mg/kg, 200 mg/kg, 25 mg/kg, and 284 mg/kg body weight, corresponding to valine, isoleucine, leucine, β-alanine, creatine, l -carnitine, quercetin, and betaine, respectively, which was based on the available literature [ 4 , 10 , 11 , 12 , 13 , 14 , 15 ]. The formula was administrated twice a day at half the total daily dose via oral gavage at 8:00 am and 8:00 pm for 3 d and 7 d, respectively, after which an exhaustive treadmill test was performed to assess the acute effect of the formula on exercise performance, the volume of oral-gavage was 15 mL/kg body weight.…”

“…The formula was administrated twice a day at half the total daily dose via oral gavage at 8:00 am and 8:00 pm for 3 d and 7 d, respectively, after which an exhaustive treadmill test was performed to assess the acute effect of the formula on exercise performance, the volume of oral-gavage was 15 mL/kg body weight. The two timelines of 3-d or 7-d supplement were commonly applied in the evaluation of acute anti-fatigue function [ 6 , 14 , 17 ]. The entire study design is shown in Figure 1 , and is divided into two parts:…”

Nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage and accelerate recovery in athletes: current knowledge, practical application and future perspectives

“…L-Carnitine has the potential to ameliorate muscle damage signs and symptoms. In a recent review and metaanalysis, Yarizadh et al (2020) described that L-carnitine supplementation resulted in significant improvements in muscle soreness following damaging exercise in both resistance-trained and untrained populations, when compared to a placebo.…”