The Effect of L-Carnitine-Supplemented Total Parenteral Nutrition on Tissue Amino Acid Concentrations in Piglets

Böhles, H.; Michalk, Dietrich; Brandl, Ullrich; Fekl, Werner; Börresen, Hans Chr.; Stehr, K.

doi:10.1093/jn/114.4.671

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…phosphoserine. y-aminobutyrate and taurine in brain [80], Moreover, according to some ob servations, carnitine availability may alter the nitrogen balance of the organism [81. 82] providing further evidence for a relationship between certain elements of nitrogen metab olism and carnitine.…”

Section: Carnitine and Metabolism O F Nitrogen Compoundsmentioning

confidence: 99%

Carnitine Supplementation in the Premature

Melegh¹

1990

Neonatology

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In higher organisms the carnitine acyltransferases reversibly esterify carnitine which is a primary role of carnitine. With this function it is involved in the β-oxidation of long-chain fatty acids and in the regulation of CoASH/acyl-CoA ratio in the intracellular compartments. In the intrauterine life there is an increase in stores of carnitine. Many evidences show, that in this growth rate a determinant factor is the materno-fetal transport of carnitine. After interruption of this materno-fetal unit the premature infant depends on exogenous intake. In absence of the exogenous intake due to carnitine free nutrition the tissue carnitine reserves decline in preterm infants. Human milk and many formulas contain carnitine. In carnitine deficiency (insufficiency) syndromes besides of the impairment of oxidation of long chain fatty acids, depending on the degree of carnitine depletion, possible development of multiple deterioration of intracellular processes has been suggested. Impairment of lipid metabolism in preterm infants maintained on carnitine-free feeding regimens seems to be established, in turn, numerous supplemental works suggest a rationale for prevention of decrease of body reserves.

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Section: Carnitine and Metabolism O F Nitrogen Compoundsmentioning

confidence: 99%

Carnitine Supplementation in the Premature

Melegh¹

1990

Neonatology

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“…Furthermore, L ‐carnitine appears to play a role in the metabolism of amino acids. Animal tissues often contain acyl‐carnitine derivatives of branched‐chain amino acids (BCAA: leucine, isoleucine or valine) (Bohles et al. 1984; Ji et al.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, L-carnitine appears to play a role in the metabolism of amino acids. Animal tissues often contain acylcarnitine derivatives of branched-chain amino acids (BCAA: leucine, isoleucine or valine) (Bohles et al 1984;Ji et al 1987;Weisdorf et al 1991). Hayashi et al (1996) observed a glutamine-sparing effect of L-carnitine in tissues of rats.…”

Section: Introductionmentioning

confidence: 99%

Changes in amino acid composition in the tissues of African catfish (Clarias gariepinus) as a consequence of dietary L-carnitine supplements

et al. 2002

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A study was undertaken to examine the effect of different amounts of dietary lysine (13 and 21 g kg−1 diet), lipid (80 and 160 g kg−1 diet) and L‐carnitine (0.2 and 1.0 g kg−1 diet) on growth performance, proximate composition and amino acid metabolism of the African catfish (Clarias gariepinus). Juvenile African catfish (23 ± 1.5 g/fish) were stocked into 70‐L aquaria (16 aquaria, 28 fish/aquarium) connected to a recirculation system during a maximum period of 74 days. All groups were fed at a level of 24 g kg−0.8 day−1 in an experiment run at pair feeding. Animals receiving 1.0 g carnitine accumulated up to six times more carnitine in their tissues than animals receiving 0.2 g (P < 0.05). Acyl‐carnitine and free L‐carnitine levels increased in the whole body and in tissues. Dietary L‐carnitine supplements increased protein‐to‐fat ratios in the body, but did not affect growth rate. Protein‐to‐fat ratios were only affected when the biosynthesis capacity of L‐carnitine was restricted due to low lysine levels and when there was a shortage of dietary fat. When lysine was offered at 21 g kg−1 feed, dietary L‐carnitine supplements did not affect the amino acid concentrations of body tissues. Dietary L‐carnitine supplements raised the concentration of glutamic acid > aspartic acid > glycine > alanine > arginine > serine > threonine in skeletal muscle tissue (P < 0.05). Total amino acid concentration in muscle and liver tissues (dry‐matter basis) increased from 506 to 564 and from 138 to 166 mg g−1, respectively, when diets were offered with high L‐carnitine, low lysine and low fat levels. These data suggest that dietary L‐carnitine supplementation may increase fatty acid oxidation and possibly decrease amino acid combustion for energy.

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“…The L-carnitine concentration gradient was even more pronounced between muscle and liver tissues (Ozório et al 2001). The ability to take up and retain dietary carnitine was observed in other species, such as Atlantic salmon Salmo salar L. (Ji et al 1996), red seabream Pagrus major (Chatzifotis and Takeuchi 1997), rabbits (Bell et al 1992), piglets (Böhles et al 1984), rats (Tsai et al 1974), among other species (Li et al 2017).…”

Section: Discussionmentioning

confidence: 92%

Oxidative effect of l-carnitine on energy metabolism in diploid and triploid rainbow trout (Oncorhynchus mykiss): impact on metabolites

et al. 2018

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L-Carnitine plays a key role in the regulation of energy metabolism and growth in fish. The aim of this study was to determine the effects of dietary L-carnitine levels on carnitine homeostasis and energy metabolism in diploid and triploid trout (Oncorhynchus mykiss). Diploid and triploid trout (29.5 ± 0.6 and 31.8 ± 0.5 g, respectively) were fed with three diets supplemented with 15, 200 or 530 mg L-carnitine/kg, respectively, for 56 days. Compared to 15 mg L-carnitine, total carnitine content increased in the liver by 182% in diploid and by 154% in triploid trout fed 530 mg L-carnitine. In muscle, total carnitine content increased by 60 and 73% in diploid and by 34 and 75% in triploid with the increase in dietary L-carnitine levels. L-Carnitine caused no significant change in the plasma concentrations of metabolites like proteins (ammonia, urea and protein), lipid (triglycerides), carbohydrate (glucose, lactate) and enzyme activities (lipase, lactate, alanine transaminase, lactic acid dehydrogenase). Triploid trout had significantly lower plasma ammonia (P = 0.003), lipase (P = 0.005) and triiodothyronine (T 3 ; P = 0.003) levels than diploid trout. In conclusion, ploidy significantly affected the energy metabolism in rainbow trout, dietary L-carnitine levels altered the L-carnitine homeostasis, but not influence nutritional metabolism.

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The Effect of L-Carnitine-Supplemented Total Parenteral Nutrition on Tissue Amino Acid Concentrations in Piglets

Cited by 9 publications

References 15 publications

Carnitine Supplementation in the Premature

Carnitine Supplementation in the Premature

Changes in amino acid composition in the tissues of African catfish (Clarias gariepinus) as a consequence of dietary L-carnitine supplements

Oxidative effect of l-carnitine on energy metabolism in diploid and triploid rainbow trout (Oncorhynchus mykiss): impact on metabolites

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