1997
DOI: 10.1016/s0955-2863(97)00110-1
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The effect of l-dopa administration and folate deficiency on plasma homocysteine concentrations in rats

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Cited by 25 publications
(29 citation statements)
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“…It is also possible that L-dopa treatment for several years may result in greater Hcy elevations than seen after a few months of therapy, although the only empiric data on this point suggests L-dopa-induced hyperhomocysteinemia in rats attenuates with chronic use. 6 This issue requires further study. The L-dopa-induced elevation of tHcy was inversely related to the baseline tHcy.…”
Section: Discussionmentioning
confidence: 97%
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“…It is also possible that L-dopa treatment for several years may result in greater Hcy elevations than seen after a few months of therapy, although the only empiric data on this point suggests L-dopa-induced hyperhomocysteinemia in rats attenuates with chronic use. 6 This issue requires further study. The L-dopa-induced elevation of tHcy was inversely related to the baseline tHcy.…”
Section: Discussionmentioning
confidence: 97%
“…5,6 Previous cross-sectional studies in humans have found that tHcy was higher among L-dopa using compared to non-using PD patients. [7][8][9] A recent prospective study reported elevation in tHcy among 20 Japanese patients after L-dopa treatment.…”
mentioning
confidence: 99%
“…A common acquired cause of elevated plasma Hcy levels is represented by L-dopa (3,4-dihydroxyphenylalanine) therapy (Daly et al 1997, Zoccolella et al 2005a). L-dopa is metabolized by catechol-O-methyltransferase (COMT) in both brain and peripheral tissues.…”
Section: Effect Of Levodopa Treatment On Plasma Hcy Levelsmentioning
confidence: 99%
“…Other pathways involved in L-dopa-induced hyperHcy, are represented by: (1) decreased re-methylation of Hcy, which may result from exhaustion of the pool of methyl groups, also induced by deficiency of folate and vitamin B12 levels, or by genetically determined inefficiency of MS or MTHFR; and (2) dysfunction in transsulfuration pathway, induced by deficiency of vitamin B6, by lack of allosteric activation in CBS by SAM, or by genetic inefficiency of CBS. Experimental studies demonstrated a significant increase in Hcy concentration after L-dopa treatment (Daly et al 1997); this effect is related to a significant decrease in SAM and increase in SAH concentrations in brain and peripheral tissues (Ordez and Wurtman 1974, Taufek and Bone, 1980, Fuller et al 1984, Daly et al 1997. These effects could be prevented by COMT inhibitors treatment and accentuated during folate deficiency (Daly et al 1997).…”
Section: Effect Of Levodopa Treatment On Plasma Hcy Levelsmentioning
confidence: 99%
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