The effect of L-DOPA administration on thyrotropin (TSH) and thyrotropin releasing hormone (TRH) levels in serum in primary or pituitary hypothyroidism.

Mitsuma, Terunori; Hirooka, Y; Wanibe, Shunmatsu; Nihei, Noriyuki

doi:10.1507/endocrj1954.25.499

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…TRH synthesis and release are controlled at the hypothalamic level by norepinephrinergic (21)(22)(23) and serotoninergic facilitatory pathways (24). The dopaminergic pathway seems to have an inhibitory role (25,26). Norepinephrinergic hyperactivity at the hypothalamic level may cause TRH oversecretion with secondary down-regulation of the thyrotrophes.…”

Section: Prolonged Trh Administration In Manmentioning

confidence: 99%

Neuroendocrine Dysfunction in Cluster Headache

Leone¹,

Patruno²,

Vescovi³

et al. 1990

Cephalalgia

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Current views on cluster headache pathogenesis indicate a primary central nervous system dysfunction, in particular a hypothalamic involvement. To confirm the hypothalamic involvement in cluster headache we evaluated the hypothalamic-pituitary axis responsiveness with the thyrotrophin releasing hormone (TRH) test. A dose of 200 micrograms of TRH was administered i.v. to nine healthy controls, 32 patients with cluster headache during cluster period and 16 in remission period. Delta maximum thyrotrophin (TSH) was significantly lower in patients with cluster headache during cluster period (p less than 0.05 versus healthy controls and cluster headache patients in remission). No difference was observed between healthy controls and cluster headache patients in remission. A monoaminergic dysfunction at the hypothalamic level is hypothesized.

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Section: Prolonged Trh Administration In Manmentioning

confidence: 99%

Neuroendocrine Dysfunction in Cluster Headache

Leone¹,

Patruno²,

Vescovi³

et al. 1990

Cephalalgia

View full text Add to dashboard Cite

show abstract

“…Japon. April 1981 (Miyai et al, 1974 ;Delitala, G., 1977 ;Mitsuma et al, 1978 reported by Scanlon et al (1977) and Delitala et al (1980). The present observation indicates that there is a sex difference with respect to dopaminergic modulation of TSH secretions in hypothyroidism.…”

Section: Endocrinolmentioning

confidence: 51%

“…It has been reported that dopamine infusion had an inhibitory effect on the TSH secretion in healthy controls (Burrows et al, 1977) and in primary hypothyroidism (Delitala, G., 1977 ;Mitsuma et al, 1978), while 1-Dopa did not exert a suppressive effect in normal control but in primary hypothyroidism inhibitory action was seen (Rapport et al, 1973;Refetoff et al, 1974;Eddy et al, 1977).…”

mentioning

confidence: 98%

Evidence of sex difference in dopaminergic modulation of serum tsh secretion in primary hypothyroidism.

et al. 1981

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We have demonstrated the sex difference with respect to the dopaminergic modulation of serum TSH secretion in patients with primary hypothyroidism. Ten patients, 4 men and 6 women, with hypothyroidism were given 10 mg of Domperidone (Domp) iv, a very potent and specific dopamine receptor blocking agent, which could not readily cross the blood brain barrier. There was a significant rise in the TSH level after Domp iv in female patients with primary hypothyroidism, from basal values at zero time at 74.4 +/- 33.8 (M +/- SE) microU/ml to 171.2 +/- 94.9 at 30 min (p less than 0.001), 159.6 +/- 100.5 at 60 min (p less than 0.001). In contrast, no significant change in serum TSH values after Domp iv occurred in male patients with primary hypothyroidism, from basal values at zero time of 181.1 +/- 39.9 microU/ml to 171.4 +/- 31.1 at 30 min, 180.7 +/- 33.2 at 60 min and 172.7 /+- 31.0 at 90 min. After thyroid hormone therapy, max delta TSH values and the change from basal to peak values were significantly related to basal TSH values in female patients with primary hypothyroidism (r = +0.93, p less than 0.001), while max delta TSH in male patients was inversely related to basal TSH values within the limited concentrations (r - =0.78, p less than 0.02). It was conjectured from our results that maximum TSH responses to intravenous administration of domperidone in male and female hypothyroid patients were observed in respectively different basal TSH values, that is, less than 100 microU/ml in males and more than 100 microU/ml in females. Our findings provided evidence of sex difference in dopaminergic modulation of TSH secretion in primary hypothyroidism.

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The effect of L-DOPA administration on thyrotropin (TSH) and thyrotropin releasing hormone (TRH) levels in serum in primary or pituitary hypothyroidism.

Cited by 2 publications

References 12 publications

Neuroendocrine Dysfunction in Cluster Headache

Neuroendocrine Dysfunction in Cluster Headache

Evidence of sex difference in dopaminergic modulation of serum tsh secretion in primary hypothyroidism.

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