The effect of labour and maternal oxytocin infusion on fetal plasma oxytocin concentration

Patient, Charlotte; Davison, John M.; Charlton, L.; Baylis, P. H.; Thornton, Steven

doi:10.1111/j.1471-0528.1999.tb08188.x

Cited by 35 publications

(30 citation statements)

References 18 publications

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“…This efficacy may be supported by our results since the uterus was able to respond to oxytocin at advanced stages of the parturition process. On the other hand, it has been demonstrated that oxytocin is not transferred across the placenta in sheep and humans (Patient et al, 1999;Glatz et al, 1980). In addition, the placenta in pigs is epitheliochorial (it has two complete epithelia and isolates the fetus from the mother) and in humans it is hemochorial (it provides direct access to maternal blood for oxygen-CO 2 exchange and other maternal-fetal transport including glucose and aminoacids) (Enders and Carter, 2004), we therefore consider that our results were related to the actions of oxytocin on the uterine muscle without any direct effects on the piglets.…”

Section: Discussionmentioning

confidence: 99%

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

et al. 2007

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Oxytocin is extensively used to induce or augment uterine contractions, especially to facilitate the third stage of labor in humans. Administration of oxytocin to parturient sows reduces duration of labor whereas mortality of the offspring may remain unchanged. This study aimed to evaluate whether time of administration of oxytocin during parturition may alter the uterine response and fetal outcomes. Two hundred parturient sows were randomly assigned to intramuscularly receive either saline solution (control group) or oxytocin 0.083 IU/kg immediately after the delivery of the 1 st , 4 th or 8 th piglet (groups O-1, O-4 and O-8, respectively). Uterine effects and fetal outcomes were registered in all groups. The duration of labor was 20-40 min shorter (P < 0.0001) and time interval between babies was reduced by 3-5 min (P < 0.0001) in the three groups receiving oxytocin. The duration and intensity of contractions, meconium-stained piglets and intrapartum deaths decreased as time at which oxytocin administered during labor was increased. In group O-8, we observed approximately 70% less meconium-stained piglets and intrapartum deaths than in the control group. In conclusion, oxytocin administered at early phases of parturition to sows may increase duration and intensity of uterine contractions as well as adverse fetal outcomes.

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Section: Discussionmentioning

confidence: 99%

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

et al. 2007

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“…However, others could not confirm OT passage across the placenta in vivo (Patient et al, 1999). Moreover, in addition to the placenta, OT degrading placental leucine aminopeptidase and the fetal blood-brain barrier may only permit a small fraction of maternal OT to reach the fetal brain.…”

Section: Ot Pathways In the Intergenerational Transmission Of Matementioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

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Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

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“…The reported increase in fetal plasma oxytocin concentration during spontaneous labour (Chard et al 1971) has not been confirmed in studies which controlled for the effect of maternal analgesia (Patient et al 1999). It is thus unlikely that labour is initiated by an increase in fetal oxytocin.…”

Section: Amniotic and Fetal Oxytocin And Vasopressin Concentrationsmentioning

confidence: 85%

Oxytocin Antagonists: Clinical and Scientific Considerations

Thornton

Vatish

Slater

2001

Experimental Physiology

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Preterm delivery is the largest cause of perinatal mortality and morbidity, yet the treatment of preterm labour has not been demonstrated to improve outcome. The reasons are numerous and complex, but they include a failure to understand the mechanism(s) of preterm labour, the multitude of different causes, the difficulty in diagnosis and the problems of outcome measurement in clinical trials. Recently, an oxytocin antagonist (atosiban) has been introduced into clinical practice in Europe. Although it may be an effective tocolytic, a beneficial effect on perinatal outcome has not been demonstrated. Atosiban has an effect at both oxytocin and vasopressin (V1a) receptors, which (assuming efficacy) raises the question as to whether oxytocin or vasopressin V1a antagonism is required for tocolysis. This review examines the rationale for tocolysis in preterm labour, the evidence for administration of atosiban and the role for oxytocin, vasopressin and their receptors in the onset of labour.

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The effect of labour and maternal oxytocin infusion on fetal plasma oxytocin concentration

Cited by 35 publications

References 18 publications

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Oxytocin Antagonists: Clinical and Scientific Considerations

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