The effect of lacosamide on bone tissue in orchidectomised male albino Wistar rats

Simko, J; Fekete, Sona; Maláková, Jana; Kremláček, Jan; Horáček, J; Zivna, Helena; Palička, Vladimír; Živný, Pavel

doi:10.5507/bp.2014.006

Cited by 8 publications

(1 citation statement)

References 37 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The homogenates were done using 0.2 g of bone (femur) for 3 mL of phosphate buffer saline (PBS) [17]. The proximal portion of each femur was cut, weighed (0.2 g) and ground on a grinding stone, which had beforehand been covered entirely with a hard, transparent, plastic paper.…”

Section: Bone Tissue Homogenatesmentioning

confidence: 99%

Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in Wistar rats

Florence

Huguette

Hubert

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

Background Peperomia pellucida (L.) HBK is consumed as vegetable and used in Cameroonian traditional medicine for the management of diseases and for fracture healing. Therefore the aim of this study was to evaluate the effects of the aqueous whole plant extract of Peperomia pellucida on fracture healing in female Wistar rats.MethodsA drill hole injury was created by inserting a drill bit inthe diaphysis of the femur. The aqueous extract of the whole plant of Peperomia pellucida was administered orally at the doses of 100, 200 and 400 mg/kg to adult female Wistar rats. The vehicle (distilled water) was given to the control. Besides these rats, one group of rats without fracture received the extract (400 mg/kg). After 14 days of treatment, the rats were sacrificed under anesthesia and the effects of the extract were evaluated on body weight, the relative weights of organs (femurs, uteri and ovaries) and on hematology. Bone (calcium, phosphorus, alkaline phosphatase) and serum biochemical parameters (calcium, phosphorus, alkaline phosphatase) were also evaluated. Radiological and histological tests were carried out on the femurs. The mineral content of the plant extract was also investigated.ResultsThe extract induced an increase in body weight at high dose and in WBCs count at low doses. Aqueous extract from Peperomia pellucida increased bone calcium at lowest dose but maintained this parameter at normal range at high dose in fractured rat. Alkaline phophatase and phosphorus concentrations reduced significantly (p < 0.01) at the dose of 400 mg/kg as compared to fractured rats. Moreover, radiological tests revealed a dose dependent formation of callus at the level of the fracture gap, confirmed by the formation of a highly dense and compact fibrocartilagenous callus. The mineral content of the plant extract revealed the presence of calcium, phosphorus, magnesium, sodium and potassium.ConclusionThe aqueous extract of P. pellucida accelerates bone healing due partly to the mineral content of the extract. These results confirm its traditional use in the treatment of bone fractures.

show abstract

Section: Bone Tissue Homogenatesmentioning

confidence: 99%

Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in Wistar rats

Florence

Huguette

Hubert

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Wnt inhibitors in normal and ovariectomised rats

Parveen

Tiwari

Jain

et al. 2018

Bone

View full text Add to dashboard Cite

The impact of antiseizure medication on bone health: A systematic review of animal studies

Parveen,

Penumallu,

Shaik

et al. 2024

Epilepsy Research

View full text Add to dashboard Cite

The effect of lacosamide on bone tissue in orchidectomised male albino Wistar rats

Abstract: We assume then that long-lasting exposure to LCM can represent a certain risk to the health of bone in the setting of gonadal insufficiency. Further studies will be needed to confirm these findings and to determine how high the risk will be in comparison to the other AEDs.

Cited by 8 publications

References 37 publications

Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in Wistar rats

Aqueous extract of Peperomia pellucida (L.) HBK accelerates fracture healing in Wistar rats

The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Wnt inhibitors in normal and ovariectomised rats

The impact of antiseizure medication on bone health: A systematic review of animal studies

Contact Info

Product

Resources

About