The effect of Lactobacillus rhamnosus hsryfm 1301 on the intestinal microbiota of a hyperlipidemic rat model

Chen, Fan; Yang, Zhenquan; Xia, Chen; Huang, Yujun; Yin, Baoshu; Guo, Feixiang; Zhao, Haiqing; Zhao, Tangyan; Qu, Henxian; Huang, Jiadi; Wu, Yunyun; Gu, Ruixia

doi:10.1186/1472-6882-14-386

Cited by 76 publications

(46 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…L. plantarum used as single or mixed with L. paracasei exhibited blood cholesterol lowering effect in high fat and cholesterol diet-fed rats [28]. L. rhamnosus hsryfm has beneficial effects on lipid metabolism in hyperlipidemic rats by regulating the gut microbiota [29]. Supplement of milk-yogurts fermented with B. longum could reduce about 50% TC, LDL-cholesterol, and TG concentrations in albino hypercholesterolemic rats.…”

Section: Discussionmentioning

confidence: 99%

Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats

Kim

Park²,

Sin

et al. 2017

Nutrients

View full text Add to dashboard Cite

Growing evidence has indicated that supplementation with probiotics improves lipid metabolism. We aimed to investigate the beneficial effects of a probiotics mixture (PM) of three strains belonging to the species Bifidobacterium (B. longum, B. lactis, and B. breve) and two strains belonging to the species Lactobacillus (L. reuteri and L. plantarum) on cholesterol-lowering efficacy in hypercholesterolemic rats. A hypercholesterolemic rat model was established by feeding a high-cholesterol diet for eight weeks. To test the effects of PM on hypercholesterolemia, hypercholesterolemic rats were assigned to four groups, which were treated daily with low (1.65 × 109 cfu/kg), medium (5.5 × 109 cfu/kg), or high (1.65 × 1010 cfu/kg) doses of probiotic mixture or simvastatin for eight weeks. Significant reductions of serum total cholesterol (TC), triacylglycerol (TG), and low-density lipoprotein (LDL)-cholesterol levels, but increases of high-density lipoprotein (HDL)-cholesterol were observed after supplementation of PM in hypercholesterolemic rats. In PM-supplemented hypercholesterolemic rats, hepatic tissue contents of TC and TG also significantly decreased. Notably, the histological evaluation of liver tissues demonstrated that PM dramatically decreased lipid accumulation. For their underlying mechanisms, we demonstrated that PM reduced expressions of cholesterol synthesis-related proteins such as sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) in the liver. Taken together, these findings suggest that PM has beneficial effects against hypercholesterolemia. Accordingly, our PM might be utilized as a novel therapeutic agent for the management of hypercholesterolemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats

Kim

Park²,

Sin

et al. 2017

Nutrients

View full text Add to dashboard Cite

show abstract

“…For example, Dorea and Roseburia, belonging to the Firmicutes, were highly abundant in the fat-1 transgenic cattle. Dorea is reported to be associated with serum TC and LDL-C levels (41). Roseburia can induce the formation of butyrate from various dietary polysaccharide substrates, is involved in the regulation of glucose metabolism, and may increase the anti-inflammatory properties of the host (42,43).…”

Section: Discussionmentioning

confidence: 99%

Insights into the function of n-3 PUFAs in fat-1 transgenic cattle

Liu

Wei

Bai

et al. 2017

Journal of Lipid Research

View full text Add to dashboard Cite

The n-3 PUFAs have many beneficial effects on human health, including roles in immunity, neurodevelopment, and preventing cardiovascular disease. In this study, we established reliable model transgenic cattle using transgenic technology and performed a systematic investigation to examine the function of n-3 PUFAs. Our results showed that expression of the gene improved several biochemical parameters related to liver function and to plasma glucose and plasma lipid metabolism. Results of global gene and plasma protein expression analysis showed that 310 genes and 13 plasma proteins differed significantly in the blood of transgenic cattle compared with WT cattle, reflecting their regulatory roles in the immune and cardiovascular systems. Finally, changes in the gut microflora were also noted in the transgenic cattle, suggesting novel roles for n-3 PUFAs in the metabolism of glucose and lipids, as well as anti-stress properties. To the best of our knowledge, this is the first report using multiple parallel analyses to investigate the role of n-3 PUFAs using models such as transgenic cattle. This study provides novel insights into the regulatory mechanism of in the immune and cardiovascular systems, as well as its anti-stress role.

show abstract

“…Currently, we also have more information on the relationships between intestinal microflora disturbances and cardiovascular complications via systemic host immune responses to bacterial antigens. 57,[93][94][95][96][97][98] Gut microbiota is universally recognized as an active organ that can modulate the overall host metabolism by promoting multiple functions, from digestion to the systemic maintenance of overall host physiology, from development of the intestinal immune system to hepatic and energy metabolism, and to modulation of the brain in terms of behavior development and motor activity. 93,99 Patients who had experienced an atherosclerotic event have been found to have higher levels of Collinsella and lower levels of Eubacterium and Roseburia in their gut microbiota than healthy control patients.…”

Section: The Pathomechanisms Of Associations Between Systemic Infectimentioning

confidence: 99%

Association between Bacterial Infection and Peripheral Vascular Disease: A Review

et al. 2015

View full text Add to dashboard Cite

There are an increasing number of data showing a clinically important association between bacterial infection and peripheral artery disease (PAD). Bacteria suspected of being involved in PAD pathogenesis are: periodontal bacteria, gut microbiota, Helicobacter pylori, and Chlamydia pneumoniae. Infectious agents may be involved in the pathogenesis of atherosclerosis via activation of a systemic or local host immunological response to contamination of extravascular tissues or the vascular wall, respectively. A systemic immunological reaction may damage vascular walls in the course of autoimmunological cross-reactions between anti-pathogen antibodies and host vascular antigens (immunological mimicry), pathogen burden mechanisms (nonspecific activation of inflammatory processes in the vascular wall), and neuroendocrine-immune cross-talk. Besides activating the inflammatory pathway, bacterial infection may trigger PAD progression or exacerbation by enhancement of platelet reactivity, by a stimulatory effect on von Willebrand factor binding, factor VIII, fibrinogen, P-selectin activation, disturbances in plasma lipids, increase in oxidative stress, and resistance to insulin. Local inflammatory host reaction and induction of atherosclerotic plaque progression and/or instability result mainly from atherosclerotic plaque colonization by microorganisms. Despite these premises, the role of bacterial infection in PAD pathogenesis should still be recognized as controversial, and randomized, controlled trials are required to evaluate the outcome of periodontal or gut bacteria modification (through diet, prebiotics, and probiotics) or eradication (using antibiotics) in hard and surrogate cardiovascular endpoints.

show abstract

The effect of Lactobacillus rhamnosus hsryfm 1301 on the intestinal microbiota of a hyperlipidemic rat model

Cited by 76 publications

References 32 publications

Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats

Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats

Insights into the function of n-3 PUFAs in fat-1 transgenic cattle

Association between Bacterial Infection and Peripheral Vascular Disease: A Review

Contact Info

Product

Resources

About