The effect of laparoscopic sleeve gastrectomy (LSG) on glycemic control in morbidly obese patients

Gaur, Amit; Naidu, C. S.; Rao, Pankaj P.; Sharma, Sanjay; Trehan, Vikram; Kulkarni, Shrirang Vasant; Pathak, Nishant; Singh, Amit; Goyal., Balram

doi:10.1016/j.ijsu.2016.02.063

Cited by 13 publications

(5 citation statements)

References 13 publications

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“…Our follow-up data confirmed the statistically significant influence of LSG, RYGBP and LGCP on glucose homeostasis, confirming reduced blood glucose and the correction of HbA1c in agreement with previous data (24). The positive effect on glucose homeostasis can be attributed to a reduction of insulin resist-ance, increased insulin secretion, and improved tissue responses to insulin (25). Slater et al (26) stated that positive effects on the glycaemic curve and remission in type 2 DM patients were evident before a pronounced body weight reduction.…”

Section: Fig 2 Comparison Of Mean Glucose Metabolism Values Before supporting

confidence: 91%

The efficacy of selected bariatric surgery methods on lipid and glucose metabolism: a retrospective 12-month study

Bužga

Petřeková

Holéczy

et al. 2018

Cent Eur J Public Health

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Section: Fig 2 Comparison Of Mean Glucose Metabolism Values Before supporting

confidence: 91%

The efficacy of selected bariatric surgery methods on lipid and glucose metabolism: a retrospective 12-month study

Bužga

Petřeková

Holéczy

et al. 2018

Cent Eur J Public Health

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“…1A, Table 2). All patients had HOMA-IR above 1.6, which is considered to be the cut-off for normal value 9 . Fasting serum IGF1 concentration was not affected six days after SG but was lower after RYGB, whereas the concentration of its binding protein IGF-BP3 was lower after both procedures, with no difference between SG and RYGB (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis

Gudbrandsen

Dankel

Skumsnes

et al. 2019

Sci Rep

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The objective of this study was to compare the biochemical changes related to glucose tolerance and lipid metabolism in non-diabetic patients shortly after vertical sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). Non-diabetic women and men with morbid obesity were studied the day before and six days after SG (N = 15) or RYGB (N = 16). Patients completed an oral glucose tolerance test (OGTT; 75 g glucose) at both visits. SG and RYGB similarly improved fasting glucose homeostasis six days after surgery, with reduced glucose and insulin concentrations. The OGTT revealed differences between the two surgery groups that were not evident from the fasting serum concentrations. Postprandial (120 min) glucose and insulin concentrations were lower after RYGB but not after SG, whereas concentrations of glucagon-like peptide-1, peptide YY, glucagon and non-esterified fatty acids were elevated after both SG and RYGB. Fasting triacylglycerol concentration did not change after surgery, but concentrations of high density lipoprotein and low density lipoprotein cholesterols were reduced in both surgery groups, with no differences between the groups. To conclude, RYGB induced a more pronounced improvement in postprandial glucose homeostasis relative to SG, possibly due to improved insulin sensitivity rather than augmented insulin concentration.

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“…Obesity surgery is the most effective way to long-term weight loss. [ 6 ] Nowadays, among many surgical approaches, laparoscopic sleeve gastrectomy (LSG) gains popularity, because of satisfactory weight loss and remission of comorbidities. Final effect of the therapy is a result of decreased stomach volume and, in consequence, lower food intake.…”

Section: Introductionmentioning

confidence: 99%

Different surgical approaches in laparoscopic sleeve gastrectomy and their influence on metabolic syndrome

Hr¹,

Olszewska²,

Czerniawski³

et al. 2018

Medicine

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Obesity is a growing health, social, and economic issue and became an epidemic, according to recent report of World Health Organization.The only method with scientifically proved efficiency of body mass loss is a surgical treatment. Laparoscopic sleeve gastrectomy (LSG) is recently a leading method in metabolic surgery. There are no standards of operative technique for LSG so far. The influence of technique modification on metabolic effect has not been described clearly.The aim of this study was to evaluate metabolic effects in patients with morbid obesity who underwent various surgical approaches of LSG.The study included 120 patients who were randomly divided into 3 groups: Group I, where bougie size was 32 French (Fr), Group II—36 Fr and Group III—40 Fr. Each group was divided into 2 subgroups, based on the distance of resection beginning from the pylorus—2 or 6 cm. Statistical analysis of: body mass index (BMI), the Percentage of Excess Weight Loss (%EWL), the Percentage of Excess BMI Loss (%EBMIL), levels of glucose and insulin on an empty stomach, glycated hemoglobin (HbA1c), insulin resistance (Homeostatic Model Assessment of Insulin Resistance Index—HOMA-IR), aspartate transaminase (AST), alanine transaminase (ALT), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and C-reactive protein (CRP) were under investigation.Statistically significant decrease in body mass, BMI, %EWL, %EBL, glucose, and insulin concentrations has been observed in all studied groups. It was the highest when the smallest calibration tube has been used (32 Fr). Similar results were observed in HOMA-IR and HbA1c levels. Statistically significant decrease of total cholesterol, LDL, and TG concentrations have been observed. Significant increase of HDL in every group has been also noted. Postoperative CRP values were the lowest when the smallest bougie was used.LSG is effective method of obesity treatment. Metabolic effects of LSG are the most noticeable when a small bougie size is used.

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The effect of laparoscopic sleeve gastrectomy (LSG) on glycemic control in morbidly obese patients

Abstract: LSG results in improvement in glycemic control in both diabetics and non diabetics.

Cited by 13 publications

References 13 publications

The efficacy of selected bariatric surgery methods on lipid and glucose metabolism: a retrospective 12-month study

The efficacy of selected bariatric surgery methods on lipid and glucose metabolism: a retrospective 12-month study

Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis

Different surgical approaches in laparoscopic sleeve gastrectomy and their influence on metabolic syndrome

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