The effect of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis

Baricevic, Ivona; Jones, David R.; Malenković, Vesna; Nedić, Olgica

doi:10.1111/j.1365-2265.2006.02607.x

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…According to Timmins et al (11), increased proteolysis of the predominant IGFBP-3 appears to be the main mechanism causing low total circulating IGF-I levels. Recently, we have described reduced IGF-I and IGFBP-3 levels preoperatively in patients with acute CC and during gastrointestinal inflammation (12,13). Similar findings were reported by Eivindson et al (14) in patients with active ulcerative colitis and Crohn's disease.…”

Section: Discussionmentioning

confidence: 98%

Insulin‐like growth factor I (IGF‐I) as a sensitive biomarker of catabolism in patients with gastrointestinal diseases

Nedić

Malenković

Nikolić

et al. 2007

Clinical Laboratory Analysis

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Gastrointestinal ailments evoke changes in the hypothalamic-pituitary-adrenal (HPA) axis and modulation of hepatic protein synthesis. We examined the catabolic effect of certain primary gastrointestinal diseases and surgery on the concentration of insulin-like growth factor I (IGF-I). Blood samples from patients with gastric cancer (GC), cholecystitis (CC), or inguinal hernia (IH) were taken before and after surgery. The concentrations of IGF-I, IGF binding protein-1 (IGFBP-1), insulin, cortisol, and glucose were determined. In GC patients the concentration of IGF-I was reduced and the concentrations of IGFBP-1 and cortisol were elevated preoperatively; after surgery, IGFBP-1 normalized. In CC patients the concentration of IGF-I was low and the concentration of IGFBP-1 was high before cholecystectomy; after surgery IGFBP-1 returned to normal and the concentration of cortisol increased. In IH patients the concentration of IGF-I was low and the concentrations of IGFBP-1 and cortisol were high before surgery; after laparotomy IGFBP-1 returned to normal. The metabolic changes were present in all analyzed patient groups, regardless of the severity of disease and nutrition. The concentration of IGF-I was reduced before surgery and remained reduced after, recommending IGF-I as a metabolic marker in both pre and postoperative examination of patients.

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Section: Discussionmentioning

confidence: 98%

Insulin‐like growth factor I (IGF‐I) as a sensitive biomarker of catabolism in patients with gastrointestinal diseases

Nedić

Malenković

Nikolić

et al. 2007

Clinical Laboratory Analysis

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“…Increased amounts of serum IGFBP-1, IGFBP-2 and IGFBP-4 were measured in patients with trichinellosis (26). No change in the levels of IGFBP-1, IGFBP-2 and IGFBP-3 due to intervention was observed in patients undergoing laparoscopic cholecystectomy or open surgery (patients with gastric cancer), but sepsis induced further reduction of IGFBP-3, while IGFBP-1, IGFBP-2 and IGFBP-4 increased several fold (31,38).…”

Section: Igfbps In Hepatobiliary and Gastrointestinal Diseasesmentioning

confidence: 97%

“…In patients with liver cirrhosis, liver cysts, gastrointestinal inflammation (caused by H. pylori infection or due to other causes), cholecystitis and gastric cancer, the amount of IGFBP-3 was found to decrease and the amounts of IGFBP-2 and IGFBP-1 to increase in the circulation (22,24,(28)(29)(30)(31). In cirrhosis the alteration was more pronounced with progression of the disease from stage A to C (22).…”

Section: Igfbps In Hepatobiliary and Gastrointestinal Diseasesmentioning

confidence: 98%

“…The current view is that laparoscopy is a technique that is safer, less invasive and equally effective compared to traditional open surgery techniques. We performed a study on the influence of cholecystitis and laparoscopy on the IGF system (31). The results demonstrated that cholecystitis caused significant decrease in the concentrations of both IGF-I and IGF-II, but laparoscopy did not induce further changes.…”

Section: Igfs and Cholecystitismentioning

confidence: 99%

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Insulin-Like Growth Factors (Igfs) And Their Binding Proteins (Igfbps) As Biomarkers of Catabolism

Nedić¹,

Nikolić²,

Malenković³

et al. 2007

Journal of Medical Biochemistry

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Insulin-Like Growth Factors (Igfs) And Their Binding Proteins (Igfbps) As Biomarkers of Catabolism The life of an organism depends on its capacity to maintain equilibrium. Disease induces acute adaptive responses specific to the stimulus and the organism achieves stability through change. These changes are associated with increased growth hormone resistance and activity of the hypothalamic-pituitary-adrenal axis, altered insulin response and cytokine synthesis and, closely related to all these events, alteration of the complex system interrelating insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs) and their receptors. This review aims to provide an overview of the results obtained in our laboratory from studies of the IGF system in patients with metabolic disturbances caused by infection, hepatobiliary and gastrointestinal diseases, open or laparoscopic surgery and postoperative sepsis.

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Interaction of Insulin-Like Growth Factor-Binding Protein 2 with α2-Macroglobulin in the Circulation

2013

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Insulin-like growth factors (IGFs) play active role in mitogenic and metabolic processes. In the peripheral circulation, they are mostly bound to specific IGF-binding proteins (IGFBPs). Proteolysis of IGFBPs releases free, active IGFs. IGFBP-2 is the second most abundant of the six binding proteins and its concentration increases in catabolic states. The possible interaction between IGFBP-2 and other proteins in the circulation was investigated in this study. Our results showed that IGFBP-2 associates with α2-macroglobulin (α2M), a protease inhibitor. Formation of IGFBP-2/α2M complexes most likely contributes to the regulation of IGFBP-2 proteolysis and, thus, the activity of IGFs.

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The effect of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis

Abstract: Our results indicate that acute cholecystitis causes several significant changes in the circulating IGF system. Laparoscopy, however, does not aggravate such changes, but elevates urinary cortisol.

Cited by 4 publications

References 25 publications

Insulin‐like growth factor I (IGF‐I) as a sensitive biomarker of catabolism in patients with gastrointestinal diseases

Insulin‐like growth factor I (IGF‐I) as a sensitive biomarker of catabolism in patients with gastrointestinal diseases

Insulin-Like Growth Factors (Igfs) And Their Binding Proteins (Igfbps) As Biomarkers of Catabolism

Interaction of Insulin-Like Growth Factor-Binding Protein 2 with α2-Macroglobulin in the Circulation

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