The Effect of Laser and Laser Photosensitizer Combination on Leishmania Tropica Promastigotes in Vitro

Al-Obaidi, H. S.; Kadir, Mohammed A.; Al-Sammaraie, A. M. A.; Al-Mula, G. A.

doi:10.33899/ijvs.2006.62489

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…The effect of radiation lights in decreasing the viability of promastigote of Leishmania tropica can be explained by that, the effect was on the kinetic activities of cytochrome α that is very important in the redox reactions and effect on parasite ability to take and give the electrons so the production of ATP may be affected leading the decrease of metabolic activities of the parasitic cell leading to decrease the viability [19], this study was in agreement with Al-Obaidy et al (2006), who proved that laser diode light alone and laser photosensitiser combination inhibits the growth of promastigotes of Leishmania tropica in vitro [20], and in agreement with Al-Jeboory et al (2007), who found that laser helium neon has a significant effect on the replication number and the viability of Leishmania majore [21],…”

Section: Discussionsupporting

confidence: 88%

Evaluation of the efficacy of UV light, Laser lights and Nigella sativa alcoholic extracton the Viability of Leishmaniatropicapromastigotesin vitro

Hussein¹,

Al-Tae²,

Kadir³

2015

KUJSS

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Cutaneous leishmaniasis is a common disease in Iraq, especially in the central part of the country. Several treatments have been suggested for this disease but none is completely effective and without side effects. Several researches are focused on the development of alternative treatments. The present work aimed to evaluate the efficacy of ultra violet light, laser lights, and Nigella sativa alcoholic extract on the viability of Leishmania tropica promastigote in vitro. The study included exposure Leishmania tropica promastigote stage in vitro cultured to 2, 4, 6, 8 minutes of ultra violet light and laser lights, also exposure to 40, 50, 60, 70 mg/ml concentrations of Nigella sativa alcoholic extract, then evaluated their effects on replication number and parasiticidal rate of parasite. It was found that there was significant decrease at level(p≤0.05) in replication number of Leishmania tropica promastigotes groups which exposed to 40, 50, 60, 70 mg/ml of alcoholic extract of Nigella sativa, while there was significant decrease at level(p≤0.05) in replication number of groups exposed to 6, 8 minute of laser helium neon light and in groups exposed to 4, 6, 8 minute of laser diode light, and there was no significant decrease at level(p≥0.05) in replication number of groups exposed to 2, 4, 6, 8 minute of ultra violet light in comparison with control groups on the day 5 of incubation. There was increased in parasiticidal rate of Leishmania tropica promastigote stage with increasing the time and the concentration of exposure to radiation lights and the alcoholic extract, it was 0%, 25%,

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Section: Discussionsupporting

confidence: 88%

Evaluation of the efficacy of UV light, Laser lights and Nigella sativa alcoholic extracton the Viability of Leishmaniatropicapromastigotesin vitro

Hussein¹,

Al-Tae²,

Kadir³

2015

KUJSS

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“…The results in table (6) show that the percentage of wet ulcers of animal origin was 82,45%, a high percentage compared to dry ulcers of human origin, which constituted 17.55% of the total parasitic infections with cutaneous leishmaniasis. This clearly indicates that the main cause of this infection is L. major, which attacks the skin after a short incubation period that extends from one week to two months, compared to L. tropica, which needs a longer incubation period (Alam et al, 2011).…”

Section: Sexmentioning

confidence: 96%

“…(WHO 2021).The military operations, emigration, emigrant camps with low sanitary and health level in addition to low standard of living which affect the herd immunity my the main factors the late outbreak. The highest percent of cutaneous leishmaniasis in Iraq is in winter with the peak incidence in February whereas the lowest percent were in July in summer (Al-Obaidi et al,2016). Seasonal variation may depend on sand fly activity where the sand fly season in Iraq is from April through November and peaks in September-October (Stoops et al, 2013) No sand flies could be collected in the middle of July and August ( Amin et al, 2013, cdc 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology Study of Cutaneous Leishmaniasis in Babylon Governorate

Malak Majid Almusawi

2023

tjjpt

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Cutaneous leishmaniasis disease is considered an epidemic disease in Iraq and neighboring countries like Syria, Jordan, Turkey, Iran and Saudia Arabia kingdom .(WHO,2020). The study was performed to evaluate the Epidemiological status of cutaneous leishmaniasis in the Babylon governorate during the period 1/9/2022 to 1/3/2023 ,one hundred eighteen case visited the Al-Sadeq teaching hospital, Musaib general hospital, Alexandria general hospital, Al-Kifel general hospital and some private clinics in the governorate were studied. The infection was diagnosed by dermatologist physician . The study revealed that the percentage of infection with the CL was 39% with the age 1-14 year and 28% with age 15-24.Male were more infected with the disease (57%) than female (48%).Rural area were more epidemic with this disease (75.43%) in comparing with rural areas. Arms and legs were more exposed to infection (81.%) with ulcer than head (15.79%).Multiple ulcer represent more prevalence in the body (59.64%) comparing with the single(40.35%). Wet ulcer of zoonotic origin were more prevalent in incidence of infection (82.45%) in comparing with dry anthropoid ulcers (17.54 %).

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“…In Iraq, CL is a common and widespread skin disease, especially in the southern and central regions of the country [68]. As it is one of the endemic diseases in Iraq, both species L. major and L. tropica have been reported to be present in various parts of Iraq, especially in Baghdad [69].…”

Section: Cutaneous Leishmaniasismentioning

confidence: 99%

A review of leishmania genome, hosts, virulence factors, pathogenesis and treatment

KarimAlqaraghli

2024

World Journal of Current Med and Pharm Research

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The study aims in this review to study the Leishmania genus parasite that causes Leishmaniasis, in its clinical forms Cutaneous Leishmaniasis (CL), MucocutanousLeishmaniasis (ML) and Visceral Leishmaniasis (VL). When studying the parasite's genetic composition of the genome of the nucleus and the genome of the kinetoplast, which constitutes 10-20% of the total DNA, it was found that despite the difference in pathogenicity between the types of the parasite L., the genetic material is similar and maintains the genetic content. CL is a self-healing disease, but prompt treatment is important to avoid unattractive scarring and parasite spread. Of all the drugs of choice, Pentostam and Glucantime are the first line of treatment for all types of leishmaniasis, but there are serious attempts to discover new therapies.

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The Effect of Laser and Laser Photosensitizer Combination on Leishmania Tropica Promastigotes in Vitro

Cited by 4 publications

References 12 publications

Evaluation of the efficacy of UV light, Laser lights and Nigella sativa alcoholic extracton the Viability of Leishmaniatropicapromastigotesin vitro

Evaluation of the efficacy of UV light, Laser lights and Nigella sativa alcoholic extracton the Viability of Leishmaniatropicapromastigotesin vitro

Epidemiology Study of Cutaneous Leishmaniasis in Babylon Governorate

A review of leishmania genome, hosts, virulence factors, pathogenesis and treatment

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