The effect of lecithin on the activity of pancreatic lipase

Klein, Edmund; Lyman, R.B.; Peterson, Lois; Berger, R.I.

doi:10.1016/0024-3205(67)90026-4

Cited by 15 publications

(5 citation statements)

References 3 publications

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“…The same is probably true for most dietary lipids when presented to the digestive enzymes. We, as well as others, have previously shown that artificial emulsions of triglycerides with a surface cover of proteins (9,22,23) or phospholipids (9,24) are poor substrates for pancreatic lipase.…”

Section: Discussionmentioning

confidence: 76%

Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2, and bile salts.

Bläckberg¹,

Hernell²,

Olivecrona³

1981

J. Clin. Invest.

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A B S T R A C T Human milk fat globules were used to explore how dietary triglycerides are hydrolyzed by pancreatic lipase. These triglycerides were hydrolyzed very slowly by lipase alone as if the surface layer ofproteins and phospholipids impeded the action of the enzyme. The inhibition of lipase activity could be overcome by addition either of colipase or of pancreatic phospholipase A2. Colipase enhanced triglyceride hydrolysis in a dose-dependent manner whether bile salts were present or not. Bile salts had no effect on the activity of pancreatic lipase alone but further enhanced the activity at all concentrations of colipase tested. Bile salts were a prerequisite to relieve inhibition of lipase activity by phospholipase A2. Human milk fat globules exposed to phospholipase A2 should be representative of a physiological substrate for pancreatic lipase. A major new observation was that bile salts, even at high concentrations, stimulated triglyceride hydrolysis of such phospholipase-treated globules by pancreatic lipase also in the absence of colipase.

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Section: Discussionmentioning

confidence: 76%

Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2, and bile salts.

Bläckberg¹,

Hernell²,

Olivecrona³

1981

J. Clin. Invest.

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“…11 Interfacial adlayers of various surface active agents have been shown to exert dose-dependent effects toward delaying or slowing down lipolysis of emulsions mainly via interfacial shielding and/or competitive binding. Examples include lecithin and bile salts, 5,12,13 Tween 20/80, sodium lauryl sulfate and cetyltrimethylammonium bromide, 3,5,9 and various types of biopolymers (e.g., chitosan, polylysine, poloxamers, or otherwise commercially known as Pluronics). 7,8,10 In recent years, there has been a renewed interest to control enzymatic reactions with minimal substrate chemical modification by adsorbing either the enzymes or substrates onto a solid phase.…”

Section: Introductionmentioning

confidence: 99%

Controlling the Enzymatic Digestion of Lipids Using Hybrid Nanostructured Materials

Tan

Colliat-Dangus

Whitby

et al. 2014

ACS Appl. Mater. Interfaces

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Solid nanoparticle-lipid hybrids have been engineered by using spray drying to assemble monodisperse hydrophilic silica nanoparticles and submicron lipid (triglyceride) emulsions together into composite microparticles, which have specific activity toward enzymes. The influence of silica particle size (100-1000 nm) and emulsifier type (anionic and cationic) on the three-dimensional structure of the composite particles was investigated. The nanostructure of the hybrid particles, which is controlled by the size of the voids between the closely packed silica particles, plays a critical role in lipase action and hence lipid digestion kinetics. Confining lipid droplets within the nanostructured silica aggregates led to 2- to 15-fold enhanced rate of lipolysis in comparison with dispersed coarse oil droplets. The composite particles were tailored to enhance, retain or sustain the lipolysis kinetics of submicron lipid emulsions. The presence of repulsive nanoparticle-droplet interactions favored aqueous redispersion and fast lipolysis of the hybrid composite materials, while attractive interactions hindered redispersion and delayed lipolysis of the confined lipid droplets. Such hybrid nanomaterials can be exploited to control the gastrointestinal enzymatic action and promisingly form the basis for the next generation of foods and medicines.

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“…The presence of silica nanoparticles appears to prohibit this behavior possibly by providing a high surface area for fast lipase action and desorption of digestion products from the lipase site of action. Lecithin (used as surfactant for the SLH preparation), which is well known to act as a potent lipase inhibitor, also results in retarded rate and extent of lipolysis at the later stage of digestion . A previous study reported that pure Miglyol oil (in the absence of any lipase inhibitor) was almost completely digested at 60 min in a relatively slower rate compared with the spray‐dried SLH microparticles …”

Section: Resultsmentioning

confidence: 99%

Lyophilized Silica Lipid Hybrid (SLH) Carriers for Poorly Water‐Soluble Drugs: Physicochemical and In Vitro Pharmaceutical Investigations

Yasmin

Tan

Bremmell

et al. 2014

Journal of Pharmaceutical Sciences

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The effect of lecithin on the activity of pancreatic lipase

Cited by 15 publications

References 3 publications

Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2, and bile salts.

Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2, and bile salts.

Controlling the Enzymatic Digestion of Lipids Using Hybrid Nanostructured Materials

Lyophilized Silica Lipid Hybrid (SLH) Carriers for Poorly Water‐Soluble Drugs: Physicochemical and In Vitro Pharmaceutical Investigations

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