The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies

Carbon-Spaced Tandem-Disulfide Bond Bridge Design Addresses Limitations of Homodimer Prodrug Nanoassemblies: Enhancing Both Stability and Activatability

“…Redox-responsive homodimer prodrugs (HPs) consist of two identical drug molecules bridged by a redox-responsive chemical linkage, which can spontaneously aggregate into nanoassemblies in aqueous medium without the need for adjunct carriers. − Compared with carrier-dependent drug delivery systems such as liposomes and micelles, redox-responsive homodimer prodrug nanoassemblies (RHPNs) integrate the advantages of prodrugs and nanotechnology with ultrahigh drug loading efficiency (over 60%) and avoid carrier-related toxicity. − In addition, the redox-responsive chemical linkage can be triggered by redox substances in the tumor-specific microenvironment, enabling selective drug release. ,, Recently, RHPNs have caught significant attention for their great potential to enhance the effectiveness and safety of chemotherapeutic agents. , Despite these advantages, RHPNs are currently only in the preclinical research stage, with their antitumor efficacy limited by the challenges of simultaneously enhancing assembly ability and drug release rate. , Therefore, constructing RHPNs with a suitable chemical linkage to simultaneously enhance the assembly ability and drug release rate is critical for ensuring stability in systemic circulation and antitumor response in tumors.…”