The effect of leptin concentrations and other maternal characteristics on gestational weight gain is different according to pre‐gestational <scp>BMI</scp>: results from a prospective cohort

Franco-Sena, AB; Rebelo, Fernanda; Pinto, Thatiana de Jesus Pereira; Farias, Dayana Rodrigues; Silveira, G.V.; Mendes, RH; Henriques, VT; Kac, Gilberto

doi:10.1111/1471-0528.13826

Cited by 12 publications

(15 citation statements)

References 46 publications

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“…Our study suggested that serum leptin concentration was positively related to WG during the third trimester of pregnancy (r = 0.34, p = 0.0018, Figure 1 A) and significantly higher in women with EWG in comparison with non-EWG (p = 0.0002, Figure 1 C). This association between serum leptin concentrations and GWG during late pregnancy was in accordance with those findings in other studies [11,12,[27][28][29]. Recently, a cohort study demonstrated that leptin concentrations gradually increased during the third trimester of pregnancy (36 gestational week) and correlated with GWG in pregnant Mexican adolescents [30].…”

Section: Discussionsupporting

confidence: 91%

Effect of gestational weight gain on insulin resistance mediated by serum adipokine concentrations in advanced maternal age

et al. 2019

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IntroductionWith the implementation of the universal two-child policy, the number of pregnant women of advanced maternal age (AMA) will increase steadily. We aimed to investigate whether the effect of gestational weight gain on insulin resistance (IR) before delivery was mediated by serum adipokine concentrations in AMA.Material and methodsThis cross-sectional study included 80 pregnant women of AMA recruited consecutively before delivery from the Department of Obstetrics and Gynecology between August 2016 and July 2017. At delivery, maternal weight during the third trimester was recorded and serum adipokines were measured. IR was calculated using the homeostasis model assessment 2 (HOMA2) method.ResultsWeight gain (WG) during the third trimester was positively associated with serum leptin concentrations (r = 0.34, p = 0.0018) and HOMA-IR indices (r = 0.25, p = 0.025), but not related with serum concentration of adiponectin (r = 0.12, p = 0.28). WG during the third trimester and serum concentration of leptin were independently associated with the level of HOMA-IR by multivariate analysis. Subsequently, according to mediation analysis, the association between WG during the third trimester and HOMA-IR mediated by serum leptin concentrations was statistically significant (z = 1.588, p < 0.05).ConclusionsTaken together, our findings suggest that the relationship between WG during the third trimester and IR was mediated by serum leptin concentrations in AMA, but not serum adiponectin concentrations.

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Section: Discussionsupporting

confidence: 91%

Effect of gestational weight gain on insulin resistance mediated by serum adipokine concentrations in advanced maternal age

et al. 2019

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“…Inflammation at the maternal-fetal interface contribute to dysregulated activation of labor remain significantly higher in obese mothers at term. 126,188,189 In contrast, although some studies report a positive association between pregravid BMI and circulating resistin levels, 190,191 others report no relationship. 192,193 Taken together, these studies highlight the systemic impact of high BMI on chronic inflammation, immune activation, glucose tolerance, and insulin resistance.…”

Section: Maternal Obesity and Circulating Cytokine Environmentmentioning

confidence: 99%

“…For example, leptin, a proinflammatory mediator that modulates appetite, implantation, and immune responses during pregnancy increases with gestation 185 and drops immediately after delivery. 186,187 During pregnancy, 188 serum leptin levels positively correlate with BMI and fat mass and Trimester II Trimester I Trimester III F I G U R E 4 Immunologic clock of healthy pregnancy. Healthy gestation is associated with chronologic changes in peripheral immunity and adaptations at the maternal-fetal interface.…”

Section: Maternal Obesity and Circulating Cytokine Environmentmentioning

confidence: 99%

“…For example, leptin, a proinflammatory mediator that modulates appetite, implantation, and immune responses during pregnancy increases with gestation and drops immediately after delivery . During pregnancy, serum leptin levels positively correlate with BMI and fat mass and remain significantly higher in obese mothers at term . In contrast, although some studies report a positive association between pregravid BMI and circulating resistin levels, others report no relationship .…”

Section: Introductionmentioning

confidence: 99%

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Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

Sureshchandra

Marshall

Messaoudi

2019

Journal of Leukocyte Biology

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Maternal pregravid obesity results in several adverse health outcomes during pregnancy, including increased risk of gestational diabetes, preeclampsia, placental abruption, and complications at delivery. Additionally, pregravid obesity and in utero exposure to high fat diet have been shown to have detrimental effects on fetal programming, predisposing the offspring to adverse cardiometabolic, endocrine, and neurodevelopmental outcomes. More recently, a deeper appreciation for the modulation of offspring immunity and infectious disease‐related outcomes by maternal pregravid obesity has emerged. This review will describe currently available animal models for studying the impact of maternal pregravid obesity on fetal immunity and review the data from clinical and animal model studies. We also examine the burden of pregravid obesity on the maternal–fetal interface and the link between placental and systemic inflammation. Finally, we discuss future studies needed to identify key mechanistic underpinnings that link maternal inflammatory changes and fetal cellular reprogramming events.

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“…2013, Marino-Ortega et al . 2015), that association is not observed in obese women (Franco-Sena et al . 2015, Misra & Trudeau 2011), suggesting that increased fat mass is not the only contributor to the rise in maternal leptin levels during pregnancy.…”

Section: Perinatal Growth Restriction Prematurity and Circulatinmentioning

confidence: 98%

Modeling the impact of growth and leptin deficits on the neuronal regulation of blood pressure

Steinbrekera

Roghair

2016

Journal of Endocrinology

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The risk of hypertension is increased by intrauterine growth restriction (IUGR) and preterm birth. In the search for modifiable etiologies for this life-threatening cardiovascular morbidity, a number of pathways have been investigated, including excessive glucocorticoid exposure, nutritional deficiency, and aberration in sex hormone levels. As a neurotrophic hormone intimately involved in cardiovascular regulation whose levels are influenced by glucocorticoids, nutritional status and sex hormones, leptin has emerged as a putative etiologic and thus therapeutic agent. As a product of maternal and late fetal adipocytes as well as the placenta, circulating leptin typically surges late in gestation and declines following delivery until the infant consumes sufficient leptin-containing breast milk or accrues sufficient leptin-secreting adipose tissue to reestablish circulating levels. The leptin deficiency seen in IUGR infants is a multifactorial manifestation of placental insufficiency, exaggerated glucocorticoid exposure and fetal adipose deficit. The preterm infant suffers from the same cascade of events, including separation from the placenta, antenatal steroid exposure and persistently underdeveloped adipose depots. Preterm infants remain leptin deficient beyond term gestation, rendering them susceptible to neurodevelopmental impairment and subsequent cardiovascular dysregulation. This pathologic pathway is efficiently modeled by placing neonatal mice into atypically large litters, thereby recapitulating the perinatal growth restriction-adult hypertension phenotype. In this model, neonatal leptin supplementation restores the physiologic leptin surge, attenuates leptin-triggered sympathetic activation in adulthood and prevents leptin- or stress-evoked hypertension. Further pathway interrogation and clinical translation are needed to fully test the therapeutic potential of perinatal leptin supplementation.

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The effect of leptin concentrations and other maternal characteristics on gestational weight gain is different according to pre‐gestational BMI: results from a prospective cohort

Abstract: Leptin is associated with weight gain in normal weight and overweight pregnant women, but not in obese ones.

Cited by 12 publications

References 46 publications

Effect of gestational weight gain on insulin resistance mediated by serum adipokine concentrations in advanced maternal age

Effect of gestational weight gain on insulin resistance mediated by serum adipokine concentrations in advanced maternal age

Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

Modeling the impact of growth and leptin deficits on the neuronal regulation of blood pressure

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