The effect of levodopa on respiration and word intelligibility in people with advanced Parkinson's disease

Voice-Related Quality of Life in Adults With Neurofibromatosis Type 1

“…Likewise, the voice of PD patients is characterized by, among other things, a decreased frequency variability, phonational range, and vital capacity. 33,34 In correspondence with our results, Frost et al 35 found a mean VHI score of 27.35 in a group of PD patients who had not had surgery for deep brain stimulation of the subthalamic nucleus.…”

Vowel Articulation in Parkinson's Disease

“…These discrepancies might be explained by different pathophysiological mechanisms responsible for reduced vowel articulation on the one hand and deterioration of global motor performance on the other hand. It had been hypothesized that manifestation of rigor and hypokinesia on the voice apparatus is responsible for a variety of the observed abnormalities in parkinsonian dysarthria, for example, for aspects of dysprosody 26,27 and dysfunctional speech respiration 28 and therefore are expected to respond to dopaminergic therapy. However, regarding previous studies, the effect of dopaminergic stimulation on overall speech parameters and speech intelligibility in particular remains inconclusive.…”

Changes in Speech Characters of Patients With Parkinson’s Disease After Bilateral Subthalamic Nucleus Stimulation

“…These fluctuations are known as the ''on-off'' effect and have been confirmed to make a contribution in the aggravation of dysarthria. 4,[7][8][9][10] The main surgical treatment for PD motor symptoms is deep brain stimulation (DBS). There are three main surgical targets: the ventral intermediate nucleus, internal globus pallidus, and subthalamic nucleus (STN).…”