The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Swanton, B. J.; Iohom, Gabrielle; Wang, J. H.; Redmond, H. P.; Shorten, G.

doi:10.1097/00003643-200108000-00007

Cited by 7 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, cells that showed high-intensity fluorescence (rho+) accounted for 5-7% of unstimulated neutrophils; this proportion corresponds to previous reports (32). Higher baseline ROS production in unstimulated rho+ neutrophils from cord blood, in line with other data, could reflect their higher responsiveness to upregulation of mediators of systemic inflammation, which is also a typical physiological feature of labor (33,34). It could be supposed that circulating rho+ neutrophils represent the first line of defense, but their precise role remains unclear.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Effects of local anesthetics on the respiratory burst of cord blood neutrophils in vitro

et al. 2016

View full text Add to dashboard Cite

Background: Whether local anesthetics exert anti-inflammatory effects in fetal and newborn systemic neutrophils is unclear. The aim of the present study was to assess the effects of bupivacaine and lidocaine on the respiratory burst of cord blood neutrophils in vitro compared with adult cells. Methods: Whole cord blood (n = 12) and control adult blood samples (n = 7) were incubated with bupivacaine (0.0005, 0.005, 0.05, 1 mmol/l) and lidocaine (0.002, 0.02, 0.2, 4 mmol/l) for 1 and 4 h. The production of reactive oxygen species (ROS) by unstimulated neutrophils and the phorbol myristate acetate-induced oxidative burst were assessed by flow cytometry. A subset of neutrophils showing high fluorescence intensity (rho+) was analyzed separately. results: After 1 h incubation, local anesthetics decreased the respiratory burst in whole cord blood and adult neutrophils in a similar manner. At the clinically relevant concentration of 0.0005 mmol/l, bupivacaine was active, but its effect in cord blood cells could not be detected after 4 h. The cord blood rho+ cell subset was unresponsive to the inhibitory action of bupivacaine. In rho+ neutrophils, basal ROS production was stimulated by lidocaine at the lowest concentration tested. conclusion: Bupivacaine and lidocaine can decrease the respiratory burst in neutrophils of term newborns. t he question of the effects of local anesthetics (LAs) on fetal neutrophils arises in the clinical context of the broad application of neuraxial blockade in obstetrics. Epidural technics are the gold standard for labor intrapartum analgesia and are administered to parturients on request. By applying higher doses of LAs through the existing epidural catheter, surgical anesthesia for cesarean delivery may be easily obtained. The fetal and neonatal implications of epidural techniques are mostly considered to be indirect and dependent on modulation of maternal physiology, and are associated with a higher risk of neonatal pyrexia and sepsis evaluation, but not neonatal infection (1-3). The reasons for these findings are not sufficiently clear. However, direct fetal and neonatal effects of LAs as a result of placental drug transfer should not be entirely excluded. LAs administered epidurally enter the maternal systemic circulation and, after crossing the placental barrier, can reach the fetal circulation, with levels approximately one-third to half those seen in the maternal circulation. Furthermore, because of ion trapping and slower elimination, LAs may persist for longer in fetal and neonatal than maternal blood (4). LAs in the fetal systemic circulation have been reported to abolish an offspring's cardiovascular adaptive reaction to asphyxia (5) and have been suggested to affect blood cells. Specifically, bupivacaine has been shown to modify plasma membrane properties of fetal erythrocytes (6). In other studies, lidocaine, a prototypical amino-amide agent administered epidurally for cesarean sections, was suggested to be responsible for the inhibition of natural killer cells and neutrophil a...

show abstract

Section: Discussionsupporting

confidence: 90%

“…Interestingly, under clinical conditions, lidocaine was demonstrated to counteract the decrease in neutrophil respiratory burst during induction of anesthesia (34). Moreover, lidocaine is able to decrease cellular cAMP inversely associated with NOX activity via purinergic receptors and Gαi proteins (35,36).…”

Section: Discussionmentioning

confidence: 99%

Effects of local anesthetics on the respiratory burst of cord blood neutrophils in vitro

et al. 2016

View full text Add to dashboard Cite

show abstract

“…One clinical study examining neutrophils taken from lidocaine-treated patients detected significantly reduced superoxide anion release compared to patients who didn't receive lidocaine (166). Contrary to this finding, a clinical trial studying bolus lidocaine (1.5 mg.kg -1 ) administered at induction of anaesthesia found that lidocaine actually preserved neutrophil respiratory burst compared to neutrophils from control patients who received saline (167).…”

Section: Effects On Immune Cellsmentioning

confidence: 75%

Perioperative Intravenous Lidocaine and Metastatic Cancer Recurrence - A Narrative Review

Wall

Buggy

2021

Front. Oncol.

View full text Add to dashboard Cite

Cancer is a major global health problem and the second leading cause of death worldwide. When detected early, surgery provides a potentially curative intervention for many solid organ tumours. Unfortunately, cancer frequently recurs postoperatively. Evidence from laboratory and retrospective clinical studies suggests that the choice of anaesthetic and analgesic agents used perioperatively may influence the activity of residual cancer cells and thus affect subsequent recurrence risk. The amide local anaesthetic lidocaine has a well-established role in perioperative therapeutics, whether used systemically as an analgesic agent or in the provision of regional anaesthesia. Under laboratory conditions, lidocaine has been shown to inhibit cancer cell behaviour and exerts beneficial effects on components of the inflammatory and immune responses which are known to affect cancer biology. These findings raise the possibility that lidocaine administered perioperatively as a safe and inexpensive intravenous infusion may provide significant benefits in terms of long term cancer outcomes. However, despite the volume of promising laboratory data, robust prospective clinical evidence supporting beneficial anti-cancer effects of perioperative lidocaine treatment is lacking, although trials are planned to address this. This review provides a state of the art summary of the current knowledge base and recent advances regarding perioperative lidocaine therapy, its biological effects and influence on postoperative cancer outcomes.

show abstract

“…Attenuation of the hemodynamic response can be beneficial and prevent complications, especially in those with coronary ischemic disease 9 . When systemic lidocaine is used it decreases airways reactivity being useful in patients with asthma [10][11][12] , it decreases intraoperative anesthetic consumption 13,14 , the blockade of the systemic inflammatory response secondary to surgery 15,16 , postoperative pain 13,14,17 , and favors early hospital discharge 18 .…”

Section: Introductionmentioning

confidence: 99%

Efeito da utilização de 2 mg.kg-1 de lidocaína endovenosa na latência de duas doses diferentes de rocurônio e na resposta hemodinâmica à intubação traqueal

Vivancos¹,

Klamt²,

Garcia³

2011

Rev. Bras. Anestesiol.

View full text Add to dashboard Cite

Summary: Vivancos GG, Klamt JG, Garcia lV -effects of 2 mg.kg -1 of intravenous lidocaine on the latency of two Different Doses of Rocuronium and on the Hemodynamic Response of Orotracheal intubation.Background and objectives: lidocaine potentiates the effects of neuromuscular blockers and attenuates the hemodynamic response to orotracheal intubation. the objective of the present study was to test the effects of lidocaine on the latency of two different doses of rocuronium and on the hemodynamic response to intubation.

show abstract

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

Cited by 7 publications

References 29 publications

Effects of local anesthetics on the respiratory burst of cord blood neutrophils in vitro

Effects of local anesthetics on the respiratory burst of cord blood neutrophils in vitro

Perioperative Intravenous Lidocaine and Metastatic Cancer Recurrence - A Narrative Review

Efeito da utilização de 2 mg.kg-1 de lidocaína endovenosa na latência de duas doses diferentes de rocurônio e na resposta hemodinâmica à intubação traqueal

Contact Info

Product

Resources

About