The effect of lipedema on health-related quality of life and psychological status: a narrative review of the literature

Alwardat, Nuha; Renzo, Laura Di; Alwardat, Mohammad; Romano, Lorenzo; Santis, Gemma Lou De; Gualtieri, Paola; Carrano, Elena; Nocerino, Petronilla; Lorenzo, Antonino De

doi:10.1007/s40519-019-00703-x

Cited by 37 publications

(46 citation statements)

References 26 publications

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“…A previous study found no significant change in the expression of genes associated with inflammation in adipose-derived stem cells (ASCs) in lipedema or differentiated adipocytes [10]. These data suggest that there is no inflammatory process that may cause the edema, at least not in non-obese individuals.…”

Section: Discussionmentioning

confidence: 67%

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Lipedema and the Evolution to Lymphedema With the Progression of Obesity

Godoy¹,

Godoy²,

Capeletto³

et al. 2020

Cureus

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Section: Discussionmentioning

confidence: 67%

“…The number of macrophages increased significantly in the skin and fat in the lipedema group compared to the control group. There was also an increase in dermal vessels in the non-obese lipedema group compared to the control group [10].…”

Section: Introductionmentioning

confidence: 82%

Lipedema and the Evolution to Lymphedema With the Progression of Obesity

Godoy¹,

Godoy²,

Capeletto³

et al. 2020

Cureus

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“…[11][12][13][14]. Women with lipedema experience pain, heaviness of the affected limb, psychosocial distress, anxiety, eating disorders and the inability to lose weight as the fat tissue is highly resistant to diet and exercise [2,7,12,[15][16][17]. Symptoms may progress in the advanced stages of lipedema and are associated with increased cardiovascular and renal diseases [1,2].…”

Section: Introductionmentioning

confidence: 99%

Increase in Leptin and PPAR-γ Gene Expression in Lipedema Adipocytes Differentiated in vitro from Adipose-Derived Stem Cells

Al-Ghadban

Diaz

Singer

et al. 2020

Cells

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Lipedema is a painful loose connective tissue disorder characterized by a bilaterally symmetrical fat deposition in the lower extremities. The goal of this study was to characterize the adipose-derived stem cells (ASCs) of healthy and lipedema patients by the expression of stemness markers and the adipogenic and osteogenic differentiation potential. Forty patients, 20 healthy and 20 with lipedema, participated in this study. The stromal vascular fraction (SVF) was obtained from subcutaneous thigh (SVF-T) and abdomen (SVF-A) fat and plated for ASCs characterization. The data show a similar expression of mesenchymal markers, a significant increase in colonies (p < 0.05) and no change in the proliferation rate in ASCs isolated from the SVF-T or SVF-A of lipedema patients compared with healthy patients. The leptin gene expression was significantly increased in lipedema adipocytes differentiated from ASCs-T (p = 0.04) and the PPAR-γ expression was significantly increased in lipedema adipocytes differentiated from ASCs-A (p = 0.03) compared to the corresponding cells from healthy patients. No significant changes in the expression of genes associated with inflammation were detected in lipedema ASCs or differentiated adipocytes. These results suggest that lipedema ASCs isolated from SVF-T and SVF-A have a higher adipogenic differentiation potential compared to healthy ASCs.

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“…The psychological situation of patients diagnosed with lipoedema has already been addressed in several studies [7,8,13]. So far, all these publications have given the impression that mental health disorders such as depression or eating disorders would result from the lipoedema; it has been suggested that lipoedema is the underlying cause of the mental health disorders experienced [14].…”

Section: Lipoedema and Psychological Stressmentioning

confidence: 99%

Lipoedema and Pain: What is the role of the psyche? – Results of a pilot study with 150 patients with Lipoedema

Erbacher

Bertsch²

2020

Phlebologie

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Introduction The present exploratory study is the first so far to investigate the psychological stress in the period before the development of pain symptoms typical for lipoedema. Methods 150 patients diagnosed with lipoedema syndrome were questioned in semi-structured interviews about psychological stress and were diagnosed with psychological disorders according to ICD-10 criteria. The development of the symptoms typical for lipoedema was recorded in a second interview. Both interviews were blended together in collaboration with the patients, this means Lipoedema-associated pain and psychological stress were related to time. Result Exactly 80 % of the patients diagnosed with lipedema show a high level of psychological distress immediately before the onset of lipedema-associated symptoms! In this study, mental distress was defined as the presence of a manifest mental disorder (ICD 10 F diagnosis) such as Depression, eating disorder or post-traumatic stress disorder and/or serious psychological distress such as burnout syndrome or chronic stress. Summary These results contradict a widespread statement that all psychological problems of patients with the diagnosis lipoedema syndrome are caused solely by lipoedema, that lipoedema even causes the patient’s mental disorder.Moreover, depression and posttraumatic stress disorders are significantly related to the maximum pain intensity estimated by patients in everyday life. This demonstrates that it is imperative to rethink lipoedema therapy and to implement a psychosocial pillar in an overall therapy concept.

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The effect of lipedema on health-related quality of life and psychological status: a narrative review of the literature

Cited by 37 publications

References 26 publications

Lipedema and the Evolution to Lymphedema With the Progression of Obesity

Lipedema and the Evolution to Lymphedema With the Progression of Obesity

Increase in Leptin and PPAR-γ Gene Expression in Lipedema Adipocytes Differentiated in vitro from Adipose-Derived Stem Cells

Lipoedema and Pain: What is the role of the psyche? – Results of a pilot study with 150 patients with Lipoedema

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