Background of the Study: Assessment of QoL of patients with ESRD and CKD has been serving a notable purpose in evaluating the influence of the disease on patients. ESRD is a chronic disease condition that significantly degrades a patient’s health-related QoL, mostly because it places barrier on a patient’s health and wellness inclusive of physical health, psychological health, and social health. Aim of the Study: The main purpose of the research study is to assess the QoL of patients undergoing haemodialysis and to find out the relationship between QoL with selected socio- demographic variables. This study also examines the effects of haemodialysis on patient’s ability to perform activities of daily living (ADLs). Methods: It is a descriptive study carried out among 50 patients of Sharda Hospital, Greater Noida. Non- probability convenience sampling technique was used. The data was collected through a WHOQOL-BREF assessment scale and a validated, self-designed socio- demographic tool. Results: The result shows that there is a notable association (p<0.05) between gender and QOL (i.e. males are having better quality of life than females.). Majority 48.0% of the patients describe their overall QoL as fair 38.0% describe it as bad and about 14.0% describe it as good. Conclusion: The quality of life assessment revealed that approximately half of the patients who participated in the research have rated their quality of life as fair, while a significant portion considered it to be bad and a smaller percentage reported a good quality of life. Activities of Daily Living: Collectively describes fundamental skills required to independently care for oneself, such as bathing, eating etc.