Constraints on density as a function of pressure, temperature, and composition are crucial to understand isostatic movements during geodynamic processes. Here, we provide a systematic series of density diagrams extracted from thermodynamic calculations for a variety of crustal compositions within a wide P-T range. We quantify systematic density changes in collisional settings for relevant compositional variations and attempt to simplify the density-composition relationships. Rock densities depend strongly on pressure, temperature, and composition. Densities at some selected pressure-temperature conditions increase linearly with increasing Al 2 O 3 as well as MgO/ FeO contents in pelitic rocks. Al-and Fe-rich pelites yield the highest densities, which is mostly due to the formation of garnet but also depends on other minerals and changes of reactions. The effect of loading on densities is investigated, and we show that for deep burial, a meta-pelite rich in Fe and Mg yields much larger density changes than a dry basalt and that the burial of such a rock with a composition close to typical lower crust may result in significant negative buoyancy. Metamorphism of hydrous lower crust due to pressurization and heating thus leads to densification of thickened lower crust, while heating of dry crust leads to a decrease in density. Hence, water-loaded isostatic subsidence due to metamorphism of water-saturated lower crust is substantial and increases with the thickness and depth of the reacting layer, while dry compositions show much less or only transient densification and subsidence. The density change due to thermal expansion, an extensively used concept in geodynamic models, predicts uplift under the same P-T conditions and is an order of magnitude smaller than the density variation calculated from petrologically consistent diagrams.