The effect of localization and histological verification of endometrial polyps on infertility

Abstract

Aim Our purpose is to investigate if transcervical resection of endometrial polyps improves the fertility in ovulatory infertile women, and whether polyp histology, intrauterine location, and the technique of polypectomy have any influence on the pregnancy rates. Methods In this retrospective study, clinical data of 87 ovulatory infertile women who underwent hysteroscopy and polypectomy, and their 12-month follow-up have been analyzed. Subgroups according to the method of polyp removal (resectoscope or curettage), the polyp localization (utero-tubal, anterior, posterior, lateral, multiple) and the histological result were interpreted. Results Mean age of patients was 33.99 ± 4.24 years. There were no differences in the BMI and basal FSH levels between the subgroups. Pregnancy was recorded in 30 (34.5%) within the next 12 months without any difference between the subgroups of polypectomy method applied. Posterior wall polyp resection increased the pregnancy chance (OR 5.02), but no other differences were observed in 1-year pregnancy rates to other localizations. Removal of polyps which had normal endometrial histology had lower pregnancy rates as compared to that of polyps with hyperplasia or endometrial polyp histology results (OR 0.25). Conclusions Polypectomy improved the conception rate in the subsequent year regardless of the intrauterine localization and the method of its surgical removal. Therefore, we can conclude that polypectomy should be considered in infertile women.

Circulating PD1+Vδ1+γδ T Cell Predicts Fertility in Endometrial Polyp Patients of Reproductive-Age

“…Clinically, EP is a type of benign lesion in women with focal growth of the endometrial glands and stroma ( 2 ). EP affects approximately 7.8–34.9% of reproductive women and usually impairs fertility ( 3 , 4 ). Previous reports showed that assisted reproductive technology such as in vitro fertilization is required for 11–45% EP patients ( 5 , 6 ).…”

“…For AUB or infertility patients, however, surgeries including blind dilation and curettage, hysteroscopic polypectomy, and even hysterectomy could be applied to remove polyps ( 1 ). Published clinical data showed that polypectomy could effectively relieve symptoms of EP ( 3 , 4 ). Nevertheless, infertility is a common issue in EP patients of reproductive-age ( 5 ).…”

Spectral Artificial Vision Endoscopy for Assisting the Differential Diagnosis of Endometrial Polyps, In Vivo

“…There is therefore clinical evidence suggesting that polypectomy should be considered in infertile women. The same study suggests that when histology confirms normal or functional EPs, there is no evidence supporting that their presence has an impact on fertility [17].…”

“…The exact mechanism corelating EPs and fertility issues remains still unknown. Lőrincz et al [17], has shown that polypectomy improved the conception rate in the subsequent years regardless of the intrauterine localization and the exact method of its surgical removal. There is therefore clinical evidence suggesting that polypectomy should be considered in infertile women.…”

Comprehensive analysis of immune-related genes associated with the microenvironment of patients with unexplained infertility

“…Some studies focus on infertility with a clear etiology. According to Lőrincz et al , polypectomy can boost the fertility rate in the following year in infertile women regardless of the surgical resection methods ( 16 ). Using multivariate logistic regression analysis, Adedigba et al found that women who did not have hydrosalpinx were less likely to be infertile than those who did.…”