The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Objectives The relationship between smoking and rheumatoid arthritis (RA) has been confirmed. Most nations have ratified the Framework Convention on Tobacco Control. However, there are considerable regional differences in how effectively tobacco control measures were implemented. This study was carried out to estimate the spatiotemporal trends of smoking-related RA burdens. Methods Data were available from the Global Burden of Disease Study 2019 and were analysed by age, sex, year, and region. Joinpoint regression analysis was applied to the analysis of temporal trends in the RA burden resulting from smoking over 30 years. Results From 1990 to 2019, the number of global RA cases increased each year. The age-standardized prevalence, death, and disability-adjusted life-year (DALY) rates also increased. However, there was a wave in the changing trend of the age-standardized death rate, with the lowest point in 2012 and the highest point in 1990. Smoking, in particular, was responsible for 11.9% of total RA deaths and 12.8% of total DALYs in 1990 but only 8.5% of total RA deaths and 9.6% of total DALYs in 2019. A greater burden from smoking exposure was borne by men, older adults, and people living in high-middle and high sociodemographic index (SDI) countries and regions. Moreover, the UK demonstrated the highest reduction in age-standardized death and DALY rates over the three decades. Conclusion There were reductions in the age-standardized burdens of RA caused by smoking worldwide. Nevertheless, this continues to be an issue in some areas, and efforts to reduce smoking should be made to lessen this growing burden.

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Young BMSC-derived extracellular vesicles containing lncRNA sponging miR-1843a-5p to regulate Mob3a/YAP axis promote osteogenesis of senescent BMSCs

Qi,

Pan,

Yan

et al. 2023

Preprint

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Bone repair in elderly patients poses a huge challenge due to the age-related progressive degenerative decline in regenerative abilities attributed to the senescence of bone marrow stem cells (BMSCs). Stem cell extracellular vesicles-mediated therapy are increasingly acknowledged as a promising strategy for delaying senescence and promoting osteogenesis. Osteoinductive exosome (OI-exo) derived from young BMSCs was applied to treatment of aging bone regeneration and demonstrated to alleviate aging-related phenotypes and promote proliferation and osteogenic differentiation of senescent BMSCs in vitro. OI-exo-loaded hierarchical mesoporous bioactive glass (MBG) scaffold was applied in calvarial defect of aged rats and induced rapid bone formation and efficient enhancement in osteogenesis in vivo, though excess activity of bone resorption in senescent individuals remained a tremendous challenge in aged bone regeneration. The potential underlying mechanism of young extracellular vesicles-enhanced osteogenesis of old BMSCs was revealed that OI-exos were rich in lncRNA-ENSRNOG00000056625, which functioned as a promoter of YAP dephosphorylation and nuclear translocation, ultimately resulting in elevated proliferation and osteogenic differentiation and reduced senescence-related phenotypes. The findings herein revealed the competing endogenous RNA network lncRNA-ENSRNOG00000056625/miR-1843a-5p/Mob3a, and might provide novel insights into the extracellular vesicles-stimulated osteogenesis and the downstream YAP signaling as a potential critical pathway in aging bone regeneration.

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The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Cited by 4 publications

References 97 publications

Mesoporous bioactive glass scaffolds for the delivery of bone marrow stem cell-derived osteoinductive extracellular vesicles lncRNA promote senescent bone defect repair by targeting the miR-1843a-5p/Mob3a/YAP axis

Mesoporous bioactive glass scaffolds for the delivery of bone marrow stem cell-derived osteoinductive extracellular vesicles lncRNA promote senescent bone defect repair by targeting the miR-1843a-5p/Mob3a/YAP axis

The global magnitude and temporal trend of rheumatoid arthritis burden attributable to smoking from 1990 to 2019

Young BMSC-derived extracellular vesicles containing lncRNA sponging miR-1843a-5p to regulate Mob3a/YAP axis promote osteogenesis of senescent BMSCs

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