The Effect of Long-term Inhalation of Ortho-Xylene on the Liver

Tátrai, Erzsébet; Ungváry, G; Cseh, I. R.; Mányai, S.; Szeberényi, Sz.; Molnár, J; Morvai, V.

doi:10.1007/978-3-642-68195-0_34

Cited by 7 publications

(16 citation statements)

References 14 publications

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“…A high level of benzene in the breathing zone of fuel service station during refueling of automobiles has been reported (Tatrai et al, 1981). Benzene and related hydrocarbons are metabolized through an intermediate epoxide, which is highly reactive and possibly binds to hepatic microsomal proteins and nucleic acids leading to cytotoxic effects (Zahlsen et al, 1993).…”

mentioning

confidence: 99%

Investigation of the Potential Health Hazards of Petrol Station Attendants in Owerri Nigeria

Nwanjo¹,

Ojiako²

2010

Journal of Applied Sciences and Environmental Management

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Possible biochemical changes in hepatic and renal functions due to exposure of petrol vapour were assessed in twenty (20) petrol station attendants in Owerri, Imo State, Nigeria. A corresponding twenty healthy subjects who were not exposed to petrol or its vapour were used as controls. The results showed a significant increase in the (p<0.05) activities of alkaline phosphatase, alanine and aspartate aminotransferases for those exposed to petrol vapour from 6-10 years while the plasma bilirubin concentrations showed no significant change (p<0.05). Concentrations of serum urea, creatinine and urinary protein for those exposed to petrol vapour from 6-10 years were also significantly higher (p<0.05) when compared with the control. The results therefore indicate that exposure to petrol vapour increases the activities of some serum diagnostic liver enzymes and may also affect renal function indices. These effects, as seen from the study, are directly related to the duration of exposure and should be of interest to economic and environmental policy makers in Nigeria. @JASEM

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confidence: 99%

Investigation of the Potential Health Hazards of Petrol Station Attendants in Owerri Nigeria

Nwanjo¹,

Ojiako²

2010

Journal of Applied Sciences and Environmental Management

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“…Similar effects were observed in rabbits and mice (Ungvary, 1990). Ultrastructural examination of livers showed only minor changes: decreased hepatic glycogen in rats Ungvary et al, 1980b;Ungvary, 1990), ultrastructural changes in hepatic rough endoplasmic reticulum and mitochondria in rats Ungvary, 1990), increased autophagous bodies (Tatrai et al,1981;Ungvary, 1990), and changes in the distribution of hepatocellular nuclei in rats . Ultrastructural examination of livers showed only minor changes: decreased hepatic glycogen in rats Ungvary et al, 1980b;Ungvary, 1990), ultrastructural changes in hepatic rough endoplasmic reticulum and mitochondria in rats Ungvary, 1990), increased autophagous bodies (Tatrai et al,1981;Ungvary, 1990), and changes in the distribution of hepatocellular nuclei in rats .…”

Section: Discussion Of Health Effects By Route Of Exposurementioning

confidence: 97%

“…They include increased absolute and/or relative hepatic weight in rats (Kyrklund et al, 1987;Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990), cytochrome P-450 (Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990); microsomal enzyme activity (Elovaara et al, 1980(Elovaara et al, , 1987Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990), and proliferation of the smooth and rough endoplasmic reticulum Tatrai et al 1981;Ungvary 1990;Rydzynski et al 1992) and decreased hexobarbital sleeping time (Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990). They include increased absolute and/or relative hepatic weight in rats (Kyrklund et al, 1987;Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990), cytochrome P-450 (Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990); microsomal enzyme activity (Elovaara et al, 1980(Elovaara et al, , 1987Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990), and proliferation of the smooth and rough endoplasmic reticulum Tatrai et al 1981;Ungvary 1990;Rydzynski et al 1992) and decreased hexobarbital sleeping time (Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990).…”

Section: Discussion Of Health Effects By Route Of Exposurementioning

confidence: 99%

“…They include increased absolute and/or relative hepatic weight in rats (Kyrklund et al, 1987;Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990), cytochrome P-450 (Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990); microsomal enzyme activity (Elovaara et al, 1980(Elovaara et al, , 1987Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990), and proliferation of the smooth and rough endoplasmic reticulum Tatrai et al 1981;Ungvary 1990;Rydzynski et al 1992) and decreased hexobarbital sleeping time (Ungvary et al, 1980a;Tatrai et al, 1981;Ungvary, 1990). As in the acute studies, several intermediate studies in rats, guinea pigs, monkeys, or dogs, reported no effect on serum transaminases (Carpenter et al,1975a;Tatrai et al,1981 ) or hepatic morphology (Jenkins et al 1970;Carpenter et al 1975a). As in the acute studies, several intermediate studies in rats, guinea pigs, monkeys, or dogs, reported no effect on serum transaminases (Carpenter et al,1975a;Tatrai et al,1981 ) or hepatic morphology (Jenkins et al 1970;Carpenter et al 1975a).…”

Section: Discussion Of Health Effects By Route Of Exposurementioning

confidence: 99%

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ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate

et al. 1998

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Xylenes, or dimethylbenzenes, are among the highest-volume chemicals in production. Common uses are for gasoline blending, as a solvent or component in a wide variety of products from paints to printing ink, and in the production of phthalates and polyester. They are often encountered as a mixture of the three dimethyl isomers, together with ethylbenzene. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that are of greatest concern for public health purposes. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the bulk of this profile (ATSDR, 1995) into the mainstream scientific literature. An extensive listing of known human and animal health effects, organized by route, duration, and end point, is presented. Toxicological information on toxicokinetics, biomarkers, interactions, sensitive subpopulations, reducing toxicity after exposure, and relevance to public health is also included. Environmental information encompasses physical properties, production and use, environmental fate, levels seen in the environment, analytical methods, and a listing of regulations. ATSDR, as mandated by CERCLA (or Superfund), prepares these profiles to inform and assist the public.

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“…Bei CFY-Ratten zeigten sich nach bis zu einjähriger Exposition gegenüber 4750 mg o-Xylol/m 3 über 8 h/d, 7 d/Woche außer einer verminderten Gewichtszunahme eine Proliferation des endoplasmatischen Retikulums in der Leber ohne adverse histopathologische oder klinischchemische Veränderungen [81].…”

Section: Gentoxizität Und Kanzerogenitätunclassified

Richtwerte für Dimethylbenzole in der Innenraumluft

Umweltbundesamtes¹

2015

Bundesgesundheitsbl.

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The Effect of Long-term Inhalation of Ortho-Xylene on the Liver

Cited by 7 publications

References 14 publications

Investigation of the Potential Health Hazards of Petrol Station Attendants in Owerri Nigeria

Investigation of the Potential Health Hazards of Petrol Station Attendants in Owerri Nigeria

ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate

Richtwerte für Dimethylbenzole in der Innenraumluft

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