The Effect of Lorazepam on Sleep

Globus, Gordon G.; Phoebus, Eric C.; Fishbein, William; Boyd, Robert R.; Leventhal, Todd

doi:10.1002/j.1552-4604.1972.tb00176.x

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Its effects on deep slow-wave sleep (DSWS) are different from those of classical hypnotic benzodiazepines (BZD) since it does not significantly reduce its amount. Yet this ahsencc of reduction of DSWS has been demonstrated with various short-acting BZD [Globus et al. 1972;Borcn\tein et al.…”

Section: Introductionmentioning

confidence: 95%

Hypnotic benzodiazepines: Relationship between sleep parameters and pharmacokinetics of loprazolam

Krieger

Perianu²,

Bertagna³

et al. 1983

Drug Development Research

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benzodiazepines: Relationship between sleep parameters and pharmacokinetics of loprazolam. Drug Dev. Res. 3:143-152, 1983. In the search for a relationship between subjective and electrophysiologic sleep parameters and blood levels of loprazolam during night sleep after single and repeated administration, eight normal volunteers took loprazolam, a novel imidazo-benzodiazepine, on eight consecutive evenings. The assessment of the pharmacokinetics of the drug was done by two different methods: a high-pressure liquid chromatography-gas chromatography (HPLC-GC) measuring the parent drug specifically and a radioreceptor assay (RRA) measuring both the parent drug and the metabolites binding to the benzodiazepine-receptor; the latter gave slightly higher values indicating the existence of metabolites binding to the benzodiazepinereceptor. The elimination half-life of the parent drug was about eight hr and did not significantly increase after repeated administration; the half-life when using the RRA was somewhat longer since steady state was not reached until the fourth day. A relationship was looked for between pharmacokinetic data and either self-evaluated or polygraphic sleep parameters obtained from all-night recordings on the first and eighth treatment nights. No correspondence could be demonstrated, suggesting that the drug does not act directly on sleep systems and that its hypnotic effects may be indirect, secondary to anxiolytic effects or to deactivation of wake systems.

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Section: Introductionmentioning

confidence: 95%

Hypnotic benzodiazepines: Relationship between sleep parameters and pharmacokinetics of loprazolam

Krieger

Perianu²,

Bertagna³

et al. 1983

Drug Development Research

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The effects of flurazepam, lorazepam, and triazolam on sleep and memory

et al. 1980

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This study evaluated the effects of flurazepam 30 mg, lorazepam 4 mg, triazolam 0.5 mg, and placebo upon sleep and memory in eleven normal male subjects continuously monitored for nighttime EEG, EOG, and EMG recording. Subjects received each drug or placebo for two consecutive nights per week for 4 weeks in a repeated measures, double-blind, Latin Square design. Three hours post-administration, subjects were awakened and presented with a series of tasks. Recall was assessed immediately following task presentation and after the final morning awakening. The results showed that every drug significantly decreased stage 1, increased stage 2, and produced no change in stage 3--4 sleep in comparison to placebo. Only lorazepam significantly decreased REM percent. Post-drug recall was significantly decreased in comparison to placebo at night and was further decreased in the morning. Morning recall was significantly poorer when the return to sleep was 2.5 min or less than when the return to sleep was greater than 5 min following the nighttime awakening in all drug conditions. These results indicate that 1. failure of memory consolidation rather than failure of retrieval is the most likely explanation for the morning memory loss and 2. hypnotic drug properties, measured by latency to fall back asleep, affect memory consolidation.

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