The effect of low air-to-liquid mass flow rate ratios on the size, size distribution and shape of calcium alginate particles produced using the atomization method

Chan, Eng Seng; Lim, Tek-Kaun; Ravindra, Pogaku; Mansa, Rachel Fran; Islam, Aminul

doi:10.1016/j.jfoodeng.2011.08.010

Cited by 52 publications

(39 citation statements)

References 14 publications

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“…Pressurized air or gas can be used to flow the alginate solution from a confined tank (reservoir) through a tube to the extrusion nozzle 4, 10, 20, 26–29 instead of a feed pump such as a peristaltic pump. The delivery of alginate solution using pressurized air can minimize any pulsation problems caused by a peristaltic pump which can result in the incorporation of air bubbles in a viscous alginate solution 30.…”

Section: Air Extrusion Methodsmentioning

confidence: 99%

“…They improve the flow conditions in the bed 8 and allow flow across the beads with less pressure drop 9. Microgels in the size range of 500–2000 μm give a distinct mouth feel and provide a clear visualization of the encapsulated product 10. This could be a marketing strategy for product differentiation in a competitive market 11.…”

Section: Introductionmentioning

confidence: 99%

“…In the past, many attempts have been made to design and develop methods that can produce microgels with the size that is suitable for the desired application. Besides, the production rate, ease of operation, size distribution, possibility of contamination (e.g., oil, solvent), ability to maintain sterility, operational cost, and scale‐up ability are other factors that have been considered in the design and development stage 10, 14. The extrusion method has been well recognized as relatively simple, size‐controlled, low‐cost, and scalable formation method for microgels.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Air Extrusion System for Ionotropic Alginate Microgel Particle Formation: A Review

2016

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Ionotropic alginate microgels are commonly used for bioencapsulation applications and the air extrusion system is one of the common methods employed to produce these microgels. Although there have been many individual studies, to date no single report has comprehensively summarized the findings and results of the usage of this system. This review gives insight into the air extrusion methods, covering the setup, type, and characteristics of the system, focusing on their innovative aspects. Characterization techniques for the resulting microgels are presented, along with the influence of process variables on the product size and the development of empirical models for size prediction.

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Section: Air Extrusion Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Air Extrusion System for Ionotropic Alginate Microgel Particle Formation: A Review

2016

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“…In addition, most conventional approaches use external gelation methods and have a less control of the size, the size distribution, and the morphology of obtained particles [92,93]. In fact, deformed alginate particles with tails are often obtained using the dripping technique [94].…”

Section: Synthesis Of Hydrogel Particles Using Microdroplets As Templmentioning

confidence: 99%

Microfluidic-Based Synthesis of Hydrogel Particles for Cell Microencapsulation and Cell-Based Drug Delivery

2012

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Encapsulation of cells in hydrogel particles has been demonstrated as an effective approach to deliver therapeutic agents. The properties of hydrogel particles, such as the chemical composition, size, porosity, and number of cells per particle, affect cellular functions and consequently play important roles for the cell-based drug delivery. Microfluidics has shown unparalleled advantages for the synthesis of polymer particles and been utilized to produce hydrogel particles with a well-defined size, shape and morphology. Most importantly, during the encapsulation process, microfluidics can control the number of cells per particle and the overall encapsulation efficiency. Therefore, microfluidics is becoming the powerful approach for cell microencapsulation and construction of cell-based drug delivery systems. In this article, I summarize and discuss microfluidic approaches that have been developed recently for the synthesis of hydrogel particles and encapsulation of cells. I will start by classifying different types of hydrogel material, including natural biopolymers and synthetic polymers that are used for cell encapsulation, and then focus on the current status and challenges of microfluidic-based approaches. Finally, applications of cell-containing hydrogel particles for cell-based drug delivery, particularly for cancer therapy, are discussed.

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“…[33][34][35] There are three common methods for synthesizing alginate carriers: coacervation, 36 layer by layer, 37 and atomization. 38 Liang et al loaded paclitaxel, which was a strong hydrophobic drug, into poly (γ-glutamic acid)-poly(lactide) nanoparticles functionalized with galactosamine (P/Gal-NPs) as a new targeted drug delivery system to treat HepG2. 39 The results showed that receptor-mediated endocytosis increased the efficiency of paclitaxel compared with clinically available paclitaxel formulation.…”

Section: Introductionmentioning

confidence: 99%

Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres

Liao¹,

Liu²,

Yu³

et al. 2014

IJN

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A new microsphere consisting of inorganic mesoporous silica nanoparticles (MSNs) and organic alginate (denoted as MSN@Alg) was successfully synthesized by air-dynamic atomization and applied to the intracellular drug delivery systems (DDS) of liver cancer cells with sustained release and specific targeting properties. MSN@Alg microspheres have the advantages of MSN and alginate, where MSN provides a large surface area for high drug loading and alginate provides excellent biocompatibility and COOH functionality for specific targeting. Rhodamine 6G was used as a model drug, and the sustained release behavior of the rhodamine 6G-loaded MSN@Alg microspheres can be prolonged up to 20 days. For targeting therapy, the anticancer drug doxorubicin was loaded into MSN@Alg microspheres, and the (lysine)4-tyrosine-arginine-glycine-aspartic acid (K 4 YRGD) peptide was functionalized onto the surface of MSN@Alg for targeting liver cancer cells, hepatocellular carcinoma (HepG2). The results of the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and confocal laser scanning microscopy indicate that the MSN@Alg microspheres were successfully uptaken by HepG2 without apparent cytotoxicity. In addition, the intracellular drug delivery efficiency was greatly enhanced (ie, 3.5-fold) for the arginine-glycine-aspartic acid (RGD)-labeled, doxorubicin-loaded MSN@Alg drug delivery system compared with the non-RGD case. The synthesized MSN@Alg microspheres show great potential as drug vehicles with high biocompatibility, sustained release, and targeting features for future intracellular DDS.

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The effect of low air-to-liquid mass flow rate ratios on the size, size distribution and shape of calcium alginate particles produced using the atomization method

Cited by 52 publications

References 14 publications

Air Extrusion System for Ionotropic Alginate Microgel Particle Formation: A Review

Air Extrusion System for Ionotropic Alginate Microgel Particle Formation: A Review

Microfluidic-Based Synthesis of Hydrogel Particles for Cell Microencapsulation and Cell-Based Drug Delivery

Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres

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