The effect of low level laser (GaAlAs) therapy on the post-surgical healing of full thickness wounds in rabbits

Alipanah, Younes; Asnaashari, Mohammad; Anbari, Fahimeh

doi:10.1016/j.mla.2011.05.005

Cited by 5 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By day 14, the inflammation rate was comparable on both sides (p > 0.05). The utilization of LLLT with optimized parameters has the potential to accelerate the healing of full-thickness wounds [ 28 ]. Laser therapy enhances wound healing through a series of mechanisms that come into play during the three phases of inflammation, proliferation, and remodeling.…”

Section: Reviewmentioning

confidence: 99%

Application of Low-Level Laser Therapy in Endodontics: A Narrative Review

Mankar,

Burde,

Agrawal

et al. 2023

Cureus

View full text Add to dashboard Cite

Low-level laser therapy (LLLT) stands out in the realm of dentistry for its unique attributes that set it apart from traditional therapeutic approaches. This non-invasive and painless modality harnesses the power of low-intensity lasers, offering a distinct advantage in terms of safety and patient comfort. Unlike many conventional methods, LLLT does not rely on pharmaceutical interventions or invasive procedures, making it a gentle yet effective option for various dental applications. Its non-thermal, photobiomodulatory effects on cellular and tissue functions mark a notable departure from the more aggressive treatment modalities commonly associated with dentistry. This article provides an extensive exploration of LLLT's applications in dentistry, focusing on its mechanisms of action and biological effects, and emphasizes the uniqueness of LLLT as a transformative tool in modern dental care.

show abstract

Section: Reviewmentioning

confidence: 99%

Application of Low-Level Laser Therapy in Endodontics: A Narrative Review

Mankar,

Burde,

Agrawal

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

Section: Rabbitmentioning

confidence: 99%

“…In a closed wound study by Alipanah, Asnaashari, and Anbari, rabbits (n = 16) received a sutured bilateral incision on the buccal gingiva maxilla with the right side being the control and the left the laser-treated [26]. The left side of the maxilla was treated once for one minute following surgery with a pulsed GaAlAs laser with a wavelength of 685 nm and an energy density of 3 J/cm 2 [26]. The inflammation of the wounds was evaluated based on their intensity using an inflammation score, and a microscopic assessment was made which evaluated the inflammatory cells and rate of inflammation [26].…”

Section: Rabbitmentioning

confidence: 99%

“…The left side of the maxilla was treated once for one minute following surgery with a pulsed GaAlAs laser with a wavelength of 685 nm and an energy density of 3 J/cm 2 [26]. The inflammation of the wounds was evaluated based on their intensity using an inflammation score, and a microscopic assessment was made which evaluated the inflammatory cells and rate of inflammation [26]. The laser-treated group had a shortened inflammatory phase and the wound advanced faster into the proliferative and maturation phases of wound healing in comparison to the control group [26].…”

Section: Rabbitmentioning

confidence: 99%

See 1 more Smart Citation

Wound Photobiomodulation Treatment Outcomes in Animal Models

Lopez

Brundage

2019

Journal of Veterinary Medicine

View full text Add to dashboard Cite

The possibilities that photobiomodulation has brought on to the medical field are ever expanding and the scope it has reached is infinite. Determining how this relatively new treatment technique can be incorporated into the veterinary medical field is of interest to many medical professionals. In this review, we examine the treatment outcomes of low-level-laser therapy (LLLT) in different animal models to pinpoint any similarities between the studies. A search was conducted to identify LLLT studies using different animal models with an open or closed wound. The studies were compared to identify the laser parameters that resulted in positive treatment outcomes. The overall result of the studies examined indicated that daily laser exposure at a wavelength of a 600 or 800 nm range was the most beneficial across the rodent studies regardless of health status or wound type. More studies on rabbit, canine, and equine models are needed to explain the inconsistent results reviewed and find the correct treatment parameters for these species. Further research involving LLLT studies that focus on different factors including health status, treatment interval, wavelength, and energy density is needed to help validate our knowledge about the efficacy of using photobiomodulation in the veterinary medical field.

show abstract

Odontogenic differentiation and biomineralization potential of dental pulp stem cells inside Mg-based bioceramic scaffolds under low-level laser treatment

et al. 2016

View full text Add to dashboard Cite

This study aimed to investigate the potential of low-level laser irradiation (LLLI) to promote odontogenic differentiation and biomineralization by dental pulp stem cells (DPSCs) seeded inside bioceramic scaffolds. Mg-based, Zn-doped bioceramic scaffolds, synthesized by the sol-gel technique, were spotted with DPSCs and exposed to LLLI at 660 nm with maximum output power of 140 mw at fluencies (a) 2 and 4 J/cm to evaluate cell viability/proliferation by the MTT assay and (b) 4 J/cm to evaluate cell differentiation, using real-time PCR (expression of odontogenic markers) and a p-nitrophenylphosphate (pNPP)-based assay for alkaline phosphatase (ALP) activity measurement. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis were used for structural/chemical characterization of the regenerated tissues. Exposure of the DPSCs/scaffold complexes to the proposed LLLI scheme was associated with statistically significant increase of odontogenesis-related markers (bone morphogenetic protein 2 (BMP-2): 22.4-fold, dentin sialophosphoprotein (DSPP): 28.4-fold, Osterix: 18.5-fold, and Runt-related transcription factor 2 (Runx2): 3.4-fold). ALP activity was significantly increased at 3 and 7 days inside the irradiated compared to that in the non-irradiated SC/DPSC complexes, but gradually decreased until 14 days. Newly formed Ca-P tissue was formed on the SC/DPSC complexes after 28 days of culture that attained the characteristics of bioapatite. Overall, LLLI treatment proved to be beneficial for odontogenic differentiation and biomineralization of DPSCs inside the bioceramic scaffolds, making this therapeutic modality promising for targeted dentin engineering.

show abstract

The effect of low level laser (GaAlAs) therapy on the post-surgical healing of full thickness wounds in rabbits

Cited by 5 publications

References 31 publications

Application of Low-Level Laser Therapy in Endodontics: A Narrative Review

Application of Low-Level Laser Therapy in Endodontics: A Narrative Review

Wound Photobiomodulation Treatment Outcomes in Animal Models

Odontogenic differentiation and biomineralization potential of dental pulp stem cells inside Mg-based bioceramic scaffolds under low-level laser treatment

Contact Info

Product

Resources

About