The Effect of Low Magnesium Dialysate on Plasma, Ultrafiltrable, Erythrocyte and Bone Magnesium Concentrations from Patients on Maintenance Haemodialysis

Catto, G. R. D.; Reid, I. W.; MacLeod, M

doi:10.1159/000180413

Cited by 18 publications

(12 citation statements)

References 17 publications

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“…In our patients undergoing hemodialysis with different Mg concentrations in the dialysate, the Mg serum levels paralleled the Mg level changes in the dialysis bath, thus confirming previous findings [11][12][13][14][15]. Although the changes of the Mg serum levels were statistically significant and were maintained for 6 months, they were not associated with any significant variation of the PTH serum levels.…”

Section: Discussionsupporting

confidence: 89%

On the Effect of Magnesium on the PTH Secretion in Uremic Patients on Maintenance Hemodialysis

Gonella¹,

Bonaguidi²,

Buzzigoli³

et al. 1981

Nephron

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The Mg, Ca and immunoreactive parathyroid hormone (PTH) serum levels were determined in 22 uremic patients on chronic hemodialysis with different Mg concentrations in the dialysate. Baseline levels of PTH, Ca and Mg were obtained over a 4-month-period whilst on Mg dialysis of 1.5 mEq/l. Patients were then divided into three groups: 10 patients were dialyzed for 6 months with 0.5 mEq/l of Mg, 7 patients with 1.5 mEq/l, and 5 patients with 2.5 mEq/l Mg. At the end of the 6-month period with differentiated Mg dialysis the three groups were characterized by significantly different Mg serum levels. On the contrary, no significant changes were observed in the PTH or the Ca serum levels. The results of this study indicate that PTH secretion in uremic patients on regular hemodialysis is not appreciably influenced by the Mg serum levels.

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Section: Discussionsupporting

confidence: 89%

On the Effect of Magnesium on the PTH Secretion in Uremic Patients on Maintenance Hemodialysis

Gonella¹,

Bonaguidi²,

Buzzigoli³

et al. 1981

Nephron

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“…Increased bone Mg content has been noted in uremic patients [13][14][15][16][17]. Increase in bone Mg is suggested to inhibit the calcification of bones, thus contributing to uremic osteodystrophy [16,[18][19][20], Because of this, Mgfree dialysis was used in 16 dialysis patients.…”

Section: Introductionmentioning

confidence: 99%

Magnesium, Calcium and PTH Relationships in Dialysis Patients after Magnesium Repletion

Kenny¹,

Casillas²,

Ahmad³

1987

Nephron

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Sixteen end-stage renal disease patients who received hemodialysis for 2.9 years with no magnesium in the dialysate were evaluated for serum calcium, magnesium and parathyroid hormone (PTH) status. Eleven of these patients became hypomagnesemic with subnormal total and ultrafiltrable serum Mg concentrations (low-Mg group). The five remaining patients had consistently normal serum Mg concentrations (normal-Mg group). All had normal total and ionized serum Ca. However, the total and ionized serum Ca levels in the low-Mg group were significantly lower than those of the normal-Mg group. Within 2 weeks of Mg repletion (by dialysis against 0.25 mMof Mg), the N-terminal PTH, total and ultrafiltrable serum Mg, and the total and ionized serum Ca increased in the low-Mg group. There was a strong negative correlation between initial serum Mg and the percent change in N-terminal PTH (r = -0.833) at 2 weeks for all patients. There was also a strong positive correlation between initial ionized Ca and total serum Mg for all patients (r = 0.774). Mg repletion decreased the incidence of cramps experienced during dialysis by all patients. These data suggest that Mg-free dialysis in some patients can cause Mg depletion, which is symptomatic and which may suppress the parathyroid gland.

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“…Decreasing dialysate magnesium leads to a decline in bone magnesium. Although not correlated with length of dialysis, elevated bone magnesium content has been reported in these patients [66,67].…”

Section: Magnesium and Bone Diseasementioning

confidence: 63%

Magnesium and Bone Disease

Brautbar¹,

Gruber²

1986

Nephron

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The Effect of Low Magnesium Dialysate on Plasma, Ultrafiltrable, Erythrocyte and Bone Magnesium Concentrations from Patients on Maintenance Haemodialysis

Cited by 18 publications

References 17 publications

On the Effect of Magnesium on the PTH Secretion in Uremic Patients on Maintenance Hemodialysis

On the Effect of Magnesium on the PTH Secretion in Uremic Patients on Maintenance Hemodialysis

Magnesium, Calcium and PTH Relationships in Dialysis Patients after Magnesium Repletion

Magnesium and Bone Disease

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