The Effect of Low Molecular Weight Dextran and Haemodilution on Acid-Base Balance and Actate and Pyruvate Levels During Cardiopulmonary Bypass

Sykes, M.K.; Neematallah, F.A.; Cooke, Pauline

doi:10.1093/bja/39.2.94

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Our failure to show a correlation between pyruvate/lactate ratio and the state of oxygenation, except in a very general way (table III) accords with previous studies; Sykes, Neematallah and Cooke (1967) discussed several possible reasons for this. The presence of arteriovenous shunts is another, since the most ischaemic tissues would be likely to contribute least, or not at all, to the mixed venous blood for considerable periods.…”

Section: P/l Ratiosupporting

confidence: 92%

“…There are mathematical objections (Harris, Bateman and Gloster, 1962) to the concept of "excess lactate" (Huckabee, 1958a) and Sykes, Neematallah and Cooke (1967) have pointed out the practical difficulties of this index when satisfactory control values of pyruvate (P) and lactate (L) are not available. Essentially the same information is obtained from the ratio between these values, and L/P is commonly used as an index of anaerobic glycolysis.…”

Section: Lactate-pyruvate Relationshipmentioning

confidence: 99%

“…Blood lactate and pyruvate estimations have been used as evidence of anaerobic glycolysis (Huckabee,i958b,c) although the theoretical basis of this usage is open to question (Olson, 1963). Sykes, Neematallah and Cooke (1967) found lactate and pyruvate concentrations, during hypothermic CPBP, difficult to interpret. Harris, Seelye and Squire (1971) studied the changes in whole-body oxygen uptake during hypothermic CPBP.…”

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confidence: 99%

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On the Availability of Oxygen to the Body During Cardiopulmonary Bypass in Man

Harris¹,

Seelye²,

Barratt‐Boyes³

1974

British Journal of Anaesthesia

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The adequacy of tissue perfusion during cardiopulmonary bypass, with and without moderate hypothermia, was assessed in 33 adult patients undergoing open-heart surgery. The criterion of adequacy chosen was the whole-body oxygen consumption, suitably adjusted for weight and temperature. Within the range of pump-flows generally used, a low mixed-venous oxygen tension and a high arteriovenous oxygen-content difference were associated with better tissue oxygenation than their converse. It is argued that arteriovenous shunting is an important determinant of tissue oxygenation during cardiopulmonary bypass. Blood concentrations of pyruvate and lactate were not significantly correlated with the availability of oxygen to the tissues.

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Section: P/l Ratiosupporting

confidence: 92%

Section: Lactate-pyruvate Relationshipmentioning

confidence: 99%

mentioning

confidence: 99%

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