The Effect of <i>L</i>-Amino Acids Given Intravenously on Gastric Secretion Stimulated by Pentagastrin in Dogs

Abstract

L-Amino acid solution given intravenously in Heidenhain pouch dogs resulted in marked changes of both basal and pentagastrin-stimulated gastric secretions. During a 1-hour amino acid infusion, a significant augmentation of pentagastrin-induced secretion was observed. A significant increase of secretion during amino acid infusion was also found in dogs not infused with pentagastrin. Absolute values of HCl output were much higher in dogs in which secretion was stimulated by a combination of pentagastrin and amino acids than by amino acids alone. This increase was followed by a fall of gastric secretion in response to pentagastrin.