The effect of magnesium stearate and sodium starch glycolate on powder flowability

Svonja-Parezanovic, Gordana; Lalić-Popović, Mladena; Goločorbin-Kon, Svetlana; Todorović, Nemanja; Pavlović, Nebojša; Jovičić-Bata, Jelena

doi:10.2298/apt1950304s

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…The compressibility test was intended to see the decrease in granule volume due to tapping accompanied by vibration. MPEM granules in the F3 formula had a good compressibility index with a value below 15 [ 44 ]. Based on the four test parameters, the formula with the best granule properties was a formula containing 5% w / w PVP K30 as a binder.…”

Section: Resultsmentioning

confidence: 99%

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Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

et al. 2022

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Mangosteen fruit has been widely consumed and used as a source of antioxidants, either in the form of fresh fruit or processed products. However, mangosteen peel only becomes industrial waste due to its bitter taste, low content solubility, and poor stability. Therefore, this study aimed to design mangosteen peel extract microcapsules (MPEMs) and tablets to overcome the challenges. The fluidized bed spray-drying method was used to develop MPEM, with hydroxypropyl methylcellulose (HPMC) as the core mixture and polyvinyl alcohol (PVA) as the coating agent. The obtained MPEM was spherical with a hollow surface and had a size of 411.2 µm. The flow rate and compressibility of MPEM increased significantly after granulation. A formula containing 5% w/w polyvinyl pyrrolidone K30 (PVP K30) as a binder had the best tablet characteristics, with a hardness of 87.8 ± 1.398 N, friability of 0.94%, and disintegration time of 25.75 ± 0.676 min. Microencapsulation of mangosteen peel extract maintains the stability of its compound (total phenolic and α-mangosteen) and its antioxidant activity (IC50) during the manufacturing process and a month of storage at IVB zone conditions. According to the findings, the microencapsulation is an effective technique for improving the solubility and antioxidant stability of mangosteen peel extract during manufacture and storage.

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Section: Resultsmentioning

confidence: 99%

“…pressibility index with a value below 15 [44]. Based on the four test parameters, the formula with the best granule properties was a formula containing 5% w/w PVP K30 as a binder.…”

Section: Tablet Evaluationsmentioning

confidence: 99%

Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

et al. 2022

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“…In order to investigate the flow properties of the filling, sieve analysis and rheological measurements were taken with the ground turmeric and with the final blend. The powder flow plays an important role in the manufacture of dosage form such as capsules and it is often a critical point of the process [36]. Proper powder flow allows uniform particle packing and a constant volume-tomass ratio which maintains capsule weight uniformity and consistent physicomechanical properties of capsule dosage forms [36].…”

Section: Discussionmentioning

confidence: 99%

“…The powder flow plays an important role in the manufacture of dosage form such as capsules and it is often a critical point of the process [36]. Proper powder flow allows uniform particle packing and a constant volume-tomass ratio which maintains capsule weight uniformity and consistent physicomechanical properties of capsule dosage forms [36]. Hardy et al has also reported that the appropriate flow properties of the final blend are necessary to the production of capsules with a consistent fill weight [46].…”

Section: Discussionmentioning

confidence: 99%

“…The flowability of powder affects its behaviour mainly during the filling process. Among other parameters, moisture content, morphology and Particle Size Distribution can all influence flow [36]. In order to test the flowability of ground turmeric powder standard ASTM equipment was used according to the Ph.…”

Section: Rheological Properties Of Ground Turmeric Powdermentioning

confidence: 99%

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Formulation and investigation of turmeric extract and sodium benzoate loaded capsules

Bácskay

Sinka

Józsa

et al. 2021

APH

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Turmeric has been studied and used as a plant derivate active ingredient for centuries. Several effects of turmeric have been described, however the poor solubility of its active ingredients during the formulation development may limit oral applicability. The aim of research was to involve the development of a dietary supplement of a hard capsule containing turmeric (Curcuma longa) (ground powder from the root standardized to curcuminoid content) and sodium benzoate. The manufacturing technology and the analytic method of the formulation have been developed. Formulation studies according to the Ph. Hg. VIII. standards have been performed. The product may have insulin sensitizing and memory enhancing effects, related animal studies are ongoing.

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Investigation of the Influence of Formulation Method on Technological Parameters of Gramicidin S and β-cyclodextrin Inclusion Complexes

Drannikov

Vatlin

Trusova

et al. 2022

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Gramicidin S is a peptide antibiotic that has been widely used for more than 70 years. Gramicidin S is available in the form of tablets with a low dosage, which leads to possible deviations in the "Uniformity of dosage" parameter during manufacturing. Another limitation is the presence of lactose and sucrose in the formulation, which limits the drug application by patients demonstrating intolerance. As an alternative, we propose inclusion complexes of gramicidin S with β-cyclodextrin. Aim. The work aims to describe the influence of the methodology to prepare the inclusion complex on the characteristics and properties of the final product. Materials and methods. The gramicidin S -β-cyclodextrin inclusion complex has been prepared by dry mixing, paste complexation, coprecipitation and fluid-bed complexation. The complex formation has been confirmed by 1 H NMR spectroscopy, differential scanning calorimetry and thermogravimetry while the morphology and size by scanning electron microscopy for the solid and dynamic light scattering for the solution. The flowability, slope angle, bulk density of the obtained powders were estimated using the methods described in Russian Pharmacopoeia of the XIV edition. Results and discussion. In the present work, we prepared a set of gramicidin S and β-cyclodextrin inclusion complexes by various approaches. The thermal analysis demonstrated a significant change in the peak referring to phase transition of the substances, indicating the interaction between the components. The 1 H NMR spectroscopy reveals that the L-ornithine amino group is the part of gramicidin S involved in the complexation. Evaluating the technological properties of gramicidin S and β-cyclodextrin inclusion complexes significant variability, which is associated with the particle morphology. Complexes obtained using co-precipitation and fluid-bed complexation methods are more suitable for producing gramicidin S tablet production by direct compression technology. Conclusion. Herein, we demonstrate that the formation of the gramicidin S and β-cyclodextrin inclusion complex occurs through the L-ornithine amino group in the gramicidin S. In addition, depending on the method significant differences in the particle size and shape have been observed. The obtained results could provide valuable information for the development of new gramicidin S buccal formulations, which are more consistent in the "Uniformity of dosage" and allow to avoid the use of lactose and sucrose as excipients.

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The effect of magnesium stearate and sodium starch glycolate on powder flowability

Cited by 6 publications

References 7 publications

Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

Formulation and investigation of turmeric extract and sodium benzoate loaded capsules

Investigation of the Influence of Formulation Method on Technological Parameters of Gramicidin S and β-cyclodextrin Inclusion Complexes

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