The Effect of Magnesium Sulphate on Hemodynamics and Its Efficacy in Attenuating the Response to Endotracheal Intubation in Patients with Coronary Artery Disease

Puri, Goverdhan D; Marudhachalam, K. S.; Chari, Pramila; Suri, R.

doi:10.1213/00000539-199810000-00012

Cited by 62 publications

(56 citation statements)

References 13 publications

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“…22,23 Puri et al also reported similar observation with the changes in mean arterial pressure (MAP). 24 They reported that MAP decreased significantly (p<0.001) from after administering the study drug in the magnesium Group as compared to control group though MAP increased after intubation in both the Groups, it was significantly (p<0.001) higher than the base line in control Group as compared to magnesium group where the levels were just near baseline after intubation.…”

Section: Blood Pressurementioning

confidence: 93%

“…Puri et al studied 36 patients with coronary artery disease to evaluate the hemodynamic effects of magnesium and its efficacy in attenuating the response to intubation. 24 Magnesium Group received 50 mg/kg magnesium sulphate and the control group received normal saline solution before the induction of anesthesia. They found that there was initial insignificant (p>0.05) rise in the HR from 65.2±12.7 to 70.5±15.6 after administering the study drug and no further significant rise in HR in the magnesium Group after intubation.…”

Section: Heart Ratementioning

confidence: 99%

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A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

Kotwani

Hiwarkar³

2018

Int J Clin Trials

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Background: Laryngoscopy and tracheal Intubation are invariably associated with certain stress responses due to the sympatho-adrenal stimulation. These cardiovascular and neurohumoral alterations may directly affect the physiology and increase the risk. So far, various drugs have been tried but none has been considered ideal for blunting this presser response. We therefore, planned this comparative study to evaluate and compare the efficacy of intravenous magnesium sulphate (30 mg/kg) versus sublingual nitroglycerine spray (0.4 mg/spray) in attenuating the presser response to Laryngoscopy and Tracheal Intubation.Methods: Fifty patients, aged 15–50 years, scheduled for elective surgery under general anaesthesia, were randomly assigned to one of the two groups of 25 each, Group A (magnesium group) and Group B (nitroglycerine group). Study drug was given 90-120 seconds before tracheal intubation. Heart rate, Systolic blood pressure and Rate pressure product were recorded at different intervals after administering the study drug till 3 minutes after intubation.Results: Mean heart rate was significantly higher from the baseline at all times after administering the study drug in both the groups. Increase in systolic blood pressure as a presser response was limited to 7.25% in Group A and 5.83% in Group B from the baseline after tracheal intubation. There was relative hypotension after administration of the study drug in both the groups.Conclusions: Intravenous magnesium or sublingual nitroglycerine pre-treatment is found to be effective in attenuating the presser response to laryngoscopy and intubation. These drugs may lead to rise in HR but it is transient and dose dependent. However, both the drugs can significantly control the hypertensive response after laryngoscopy and intubation.

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Section: Blood Pressurementioning

confidence: 93%

Section: Heart Ratementioning

confidence: 99%

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

Kotwani

Hiwarkar³

2018

Int J Clin Trials

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“…Methods employed to attenuate the response include deepening the plane of anesthesia, treatment with vasodilators 10,11 adrenergic receptor blockers 9 , calcium channel blockers 10 and opioids. 12,13 Conventionally, IV lignocaine 1.5mg/ kg administered 90 sec before intubation is employed.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral Pregabalin on Hemodynamic Stress Response to Laryngoscopy and Endotracheal intubation

P.R¹

2017

jmscr

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“…These include the use of a variety of anesthetic agents, beta-blockers, vasodilators, local anesthetics including lidocaine, and magnesium. [1][2][3][4][5] Unfortunately, none of these pharmacological manipulations can consistently and effectively attenuate these adverse responses, nor are they free from complications.…”

mentioning

confidence: 99%

Comprendre les réactions hémodynamiques à l’intubation endotrachéale

Hung

2001

Can J Anesth/J Can Anesth

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The Effect of Magnesium Sulphate on Hemodynamics and Its Efficacy in Attenuating the Response to Endotracheal Intubation in Patients with Coronary Artery Disease

Cited by 62 publications

References 13 publications

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

Effect of Oral Pregabalin on Hemodynamic Stress Response to Laryngoscopy and Endotracheal intubation

Comprendre les réactions hémodynamiques à l’intubation endotrachéale

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