The effect of magnesium sulphate on intubating condition for rapid-sequence intubation: a randomized controlled trial

Kim, Mi‐Hyun; Oh, Ah Young; Han, Sung Hee; Kim, Jinhee; Hwang, Jung‐Won; Jeon, Young Tae

doi:10.1016/j.jclinane.2015.07.002

Cited by 16 publications

(26 citation statements)

References 18 publications

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“…Onset time of muscle relaxation of MgSO 4 group was significantly shorter than that of other groups and equivalent only with that of large-dose rocuronium group (0.9 mg/kg). [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

et al. 2017

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Background:The use of succinylcholine for rapid sequence induction in patients with open globe injuries may be detrimental to the eye.Aim:The aim of this study is to determine if the premedication with magnesium sulfate (MgSO4) could attenuate the increase in intraocular pressure (IOP) associated with succinylcholine injection and intubation.Setting:Operation theaters in a tertiary care University Hospital between December 2014 and July 215.Design:This was a prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial.Participants:One hundred and thirteen patients’ physical status ASA Classes I and II underwent elective cataract surgery under general anesthesia.Patients and Methods:These patients allocated into three groups: Group C (control group) received 100 ml normal saline, Group M1 received 30 mg/kg MgSO4 in 100 ml normal saline, and Group M2 received 50 mg/kg MgSO4 in 100 ml normal saline. IOP, mean arterial pressure (MAP), and heart rate (HR) reported at 5-time points related to study drug administration. In addition, any adverse effects related to MgSO4 were recorded. Intragroup and between-groups differences were examined by analysis of variance test.Results:We noticed a significant decrease in IOP in M1 (n = 38) and M2 (n = 37) groups as compared with C group (n = 38) after study drugs infusion, 2 and 5 min after intubation, P < 0.001. While the difference between M1 and M2 groups was insignificant, P = 0.296 and P = 0.647, respectively. There was a significant decrease in MAP and HR in M1 and M2 groups as compared with C group 2 and 5 min after intubation, P = 0.01. While the difference between M1 and M2 groups was insignificant, P = 1.Conclusion:MgSO4 30 mg/kg as well as 50 mg/kg effectively prevented the rise in IOP, MAP, and HR associated with rapid sequence induction by succinylcholine and endotracheal intubation.

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“…Onset time of muscle relaxation of MgSO 4 group was significantly shorter than that of other groups and equivalent only with that of large-dose rocuronium group (0.9 mg/kg). [ 23 ]…”

Section: Discussionmentioning

confidence: 99%

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

et al. 2017

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“…Its effect can vary depending on patient condition and its dosage used [18,19]. It has been reported that ketamine does not alter HR or cardiac output or facilitate the onset of rocuronium [20,21]. After the administration of ketamine in pediatric patients with chronic pulmonary hypertension who have catecholamine depletion or are taking beta-blockers, there is no change in HR or cardiac output [20].…”

Section: Discussionmentioning

confidence: 99%

“…After the administration of ketamine in pediatric patients with chronic pulmonary hypertension who have catecholamine depletion or are taking beta-blockers, there is no change in HR or cardiac output [20]. Kim et al [21] have also reported that ketamine does not alter MAP or HR or accelerate rocuronium onset time compared to controls. The discrepancy in these results among various studies might be due to differences in study protocols.…”

Section: Discussionmentioning

confidence: 99%

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Effects of thiopental sodium, ketamine, and propofol on the onset time of rocuronium in children

Jung

Kim²,

Choi

et al. 2017

Anesth Pain Med

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“…Anesthetic additive drugs like lidocaine and magnesium sulfate have become increasingly utilized, alone or in combination, in general anesthesia to meet various objectives, such as: postoperative pain reduction, reduced and more balanced anesthetic doses, hemodynamic stabilization, and improvement of surgical conditions. [1][2][3][4][5][6][7][8][9] A combination of lidocaine and magnesium sulfate in a multimodal opioidsparing-or even opioid-free anesthesia approach may reduce or eliminate the use of opioids in the perioperative period. 10,11 Opioid-sparing or opioid-free anesthesia is a relatively new strategy that is increasingly being used in daily anesthesia practice.…”

Section: Introductionmentioning

confidence: 99%

Lidocaine alone or combined with Magnesium Sulfate stabilizes hemodynamic parameters during General Anesthesia without prolonging the Neuromuscular Blockade: a randomized, double-blind, controlled trial

Garcia

Oliveira-Paula

Boer

et al. 2020

Preprint

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BackgroundLidocaine and magnesium sulfate have become increasingly utilisedin general anaesthesia. The present study evaluated the effects of these drugs, isolated or combined on the hemodynamic parameters as well as on the cisatracurium-induced neuromuscular blockade (NMB).MethodsAt a University hospital, 64 patients, ASA physical status I and II, undergoing elective surgery with similar pain stimulus, were randomly assigned to four groups. Patients received a bolus of lidocaine and magnesium sulfate before the tracheal intubation and a continuous infusion during the operation respectively: 3 mg.kg-1 and 3 mg.kg-1.h-1 (Lidocaine -L group), 40 mg.kg-1 and 20 mg.kg-1.h-1 (Magnesium - M group), equal doses of both drugs (Magnesium plus lidocaine - MLgroup) and, a equivalent volume of isotonic solution (Control - C group). Haemodynamic parameters and neuromuscular blockade features were continuously monitored until spontaneous recovery of the Traino of Four ratio (TOF=0.9).ResultsThe Lidocaine group presented a highly significant small hemodynamic fluctuation during the anesthesia induction and maintenance period (p<0.0001) with no change at NMB. The magnesium sulfate infusion alone or combined with lidocaine prolonged all the recovery characteristics (p< 0.0001). The onset time was not influenced by the studied drugs. The percentage of patients who achieved a TOF ratio of 90% without recovering the first Twich (T1-95%) was higher in the M and ML groups.ConclusionIntravenous lidocaine plays a significant role in the hemodynamic stability in patients under general anesthesia without exerting any additional impact on the NMB even combined with magnesium sulfate. Aside from prolonging all NMB recovery characteristics without altering the onset speed, magnesium sulfate enhances the TOF recovery rate without T1 recovery. Our findings may aid clinical decisions involving the use of these drugs by encouraging their association in multimodal anesthesia or other therapeutic purposes.Trial registrationNCT02483611 (registration date: 06-29- 2015).

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The effect of magnesium sulphate on intubating condition for rapid-sequence intubation: a randomized controlled trial

Cited by 16 publications

References 18 publications

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

Effects of thiopental sodium, ketamine, and propofol on the onset time of rocuronium in children

Lidocaine alone or combined with Magnesium Sulfate stabilizes hemodynamic parameters during General Anesthesia without prolonging the Neuromuscular Blockade: a randomized, double-blind, controlled trial

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