The effect of male body mass index on sperm parameters

Sekhavat, Leila; Moein, Mohammad Reza

doi:10.3109/13685530903536643

Cited by 43 publications

(29 citation statements)

References 21 publications

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“…Jensen et al [2004a] noticed a reduction in sperm concentration and total sperm count among overweight, obese, and underweight men. Men presenting with a BMI greater than 25 kg/m 2 have fewer chromatin-intact normal-motile sperm cells per ejaculate [Kort et al 2006] and a lower total sperm count and sperm motility [Sekhavat and Moein 2010]. Whereas metaanalysis of 31 studies found no evidence of an association between increased BMI and semen parameters [MacDonald et al 2010].…”

Section: Discussionmentioning

confidence: 99%

Lifestyle and semen quality: role of modifiable risk factors

Jurewicz

Radwan²,

Sobala

et al. 2013

Systems Biology in Reproductive Medicine

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(2014) Lifestyle and semen quality: role of modifiable risk factors, Systems Biology in Reproductive Medicine, 60:1, 43-51, DOI: 10.3109/19396368.2013.840687 To link to this article: https://doi.org/10. 3109/19396368.2013 AbstractThe relationship between exposure to lifestyle factors and adverse effects on human reproductive health is debated in the scientific literature and these controversies have increased public and regulatory attention. The aim of the study was to examine the association between modifiable lifestyle factors and main semen parameters, sperm morphology, and sperm chromatin structure. The study population consisted of 344 men who were attending an infertility clinic for diagnostic purposes with normal semen concentration of 20-300 M/ml or with slight oligozoospermia (semen total concentration of 15-20 M/ml) [WHO 1999]. Participants were interviewed and provided semen samples. The interview included questions about demographics, socio-economic status, medical history, lifestyle factors (consumption of alcohol, tobacco, coffee intake, cell phone and sauna usage), and physical activity. The results of the study suggest that lifestyle factors may affect semen quality. A negative association was found between increased body mass index (

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Section: Discussionmentioning

confidence: 99%

Lifestyle and semen quality: role of modifiable risk factors

Jurewicz

Radwan²,

Sobala

et al. 2013

Systems Biology in Reproductive Medicine

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“…Thirty-five studies met the inclusion criteria, but five did not pass critical appraisal due to shortcomings in their statistical analysis or reporting (Al-Ali et al, 2012Jamshidi, 2011;Relwani et al, 2011;Sekhavat and Moein, 2010) (Figure 1 Supplementary Table S1). The overall quality of included studies ranged from 4/9 to 8/9.…”

Section: Study Characteristicsmentioning

confidence: 99%

Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis

Campbell

Lane

Owens

et al. 2015

Reproductive BioMedicine Online

277

187

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This systematic review investigated the effect of paternal obesity on reproductive potential. Databases searched were Pubmed, Ovid, Web of Science, Scopus, Cinahl and Embase. Papers were critically appraised by two reviewers, and data were extracted using a standardized tool. Outcomes were: likelihood of infertility, embryo development, clinical pregnancy, live birth, pregnancy viability, infant development, sperm; concentration, morphology, motility, volume, DNA fragmentation, chromatin condensation, mitochondrial membrane potential (MMP), and seminal plasma factors. Thirty papers were included, with a total participant number of 115,158. Obese men were more likely to experience infertility (OR = 1.66, 95% CI 1.53-1.79), their rate of live birth per cycle of assisted reproduction technology (ART) was reduced (OR = 0.65, 95% CI 0.44-0.97) and they had a 10% absolute risk increase of pregnancy non-viability. Additionally, obese men had an increased percentage of sperm with low MMP, DNA fragmentation, and abnormal morphology. Clinically significant differences were not found for conventional semen parameters. From these findings it can be concluded that male obesity is associated with reduced reproductive potential. Furthermore, it may be informative to incorporate DNA fragmentation analysis and MMP assessment into semen testing, especially for obese men whose results suggest they should have normal fertility.

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“…The GnRH data also suggest that E 2 feedback at the pituitary level was not greatly altered by flutamide, inasmuch as E 2 feedback would be expected to blunt GnRH action ‘Urban et al (1988b)’. Moreover, E 2 feedback itself does not seem to change with age ‘Ten Kulve et al (2010)’.…”

Section: Discussionmentioning

confidence: 92%

Distinct roles of age and abdominal visceral fat in reducing androgen receptor‐dependent negative feedback on LH secretion in healthy men

2014

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Testosterone (T) impacts LH secretion through negative feedback via the androgen receptor (AR) in the hypothalamo-pituitary system. An untested postulate is that increasing body mass index (BMI), abdominal visceral fat (AVF) or total abdominal fat (TAF) with aging decreases LH secretion by heightening T negative feedback via AR. This hypothesis was tested in a prospective, randomized double-blind cross-over study of 19 healthy men comparing the effects of flutamide, a selective nonsteroidal AR antagonist, and placebo administration on basal and pulsatile LH secretion as a function of age and obesity measures. To this end, serum levels of 2-hydroxyflutamide (2-OHF), a major active flutamide metabolite, were measured by mass spectrometry, and AVF/TAF quantified by abdominal computerized tomography. Statistical analysis showed that antiandrogen administration elevated 6-hr mean LH concentrations to 5.4 ± 1.3 IU/L compared with 3.3 ± 1.2 IU/L for placebo (P<10−3), and total T by 35% (P<10−4). The LH-T concentration product doubled (P<10−8). According to deconvolution analysis, flutamide exposure increased total LH secretion (P<10−3) and pulsatile LH secretion (P=0.0077), along with LH pulse frequency (P=0.019). Despite feedback inhibition, the LH-T product declined as a linear function of AVF (P=0.021) and TAF (P=0.017). This was explained by the fact that higher BMI was associated with lower 2-OHF concentrations (R=-0.562, P=0.012). In contrast, age was associated with less pulsatile LH secretion (R=-0.567, P=0.011) even when LH responses were normalized to antiantrogen levels. In conclusion, increased AVF, TAF and BMI predict decreased LH and flutamide blood levels, whereas older age is marked by impaired stimulation of pulsatile LH secretion even when normalized for antiandrogen levels, suggesting different mechanisms of regulation by adiposity and age.

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The effect of male body mass index on sperm parameters

Cited by 43 publications

References 21 publications

Lifestyle and semen quality: role of modifiable risk factors

Lifestyle and semen quality: role of modifiable risk factors

Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis

Distinct roles of age and abdominal visceral fat in reducing androgen receptor‐dependent negative feedback on LH secretion in healthy men

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